-PDF Download- Nimesulide Actions And Uses EBOOK

Nimesulide - Actions and Uses

Author: K. D. Rainsford

Publisher: Springer Science & Business Media

Published: 2006-01-16

Total Pages: 445

ISBN-13: 3764374101

Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which acts as a cyclooxygenase- 2 inhibitor but also has other novel pharmacological features which account for its effect in the control of pain and inflammation. It has become a leading NSAID in over 50 countries worldwide. This book provides a comprehensive and fully up-to-date critical review of the published literature on nimesulide, including comparisons with anti-inflammatory, analgesic and antipyretic agents. The emphasis is on the action of nimesulide in relation to its therapeutic and side effects in comparison with other established NSAIDs, including the new class of Coxibs. The chapters are written by leading experts and cover development of nimesulide, including synthesis and production, introduction, and approved uses and applications, followed by pharmacokinetics and toxicological properties, adverse reactions and their mechanisms.

Hepatotoxicity

Author: Hyman J. Zimmerman

Publisher: Lippincott Williams & Wilkins

Published: 1999

Total Pages: 848

ISBN-13: 9780781719520

DOWNLOAD EBOOK →

Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Textbook of Rabbit Medicine E-Book

Author: Molly Varga

Publisher: Elsevier Health Sciences

Published: 2013-08-19

Total Pages: 464

ISBN-13: 0702054194

DOWNLOAD EBOOK →

The Textbook of Rabbit Medicine second edition is the completely revised and updated new edition of Frances Harcourt Brown’s acclaimed text covering all aspects of rabbit medicine. While the authoritative and evidence-based approach that made the original book so successful has been retained, in this new second edition well-known rabbit expert Molly Varga adds a stronger clinical focus that makes the Textbook invaluable as a point-of-care resource as well as a respected reference. With many additional features introduced for this update, the Textbook of Rabbit Medicine second edition remains the definitive and comprehensive reference of choice for all veterinary practitioners seeking information on the pet rabbit. Comprehensive, in-depth and authoritative coverage of the health and diseases of the domestic rabbit Detailed and explicit line artwork provides a clear understanding of physiological processes A practical, evidence-based resource for the effective treatment of pet rabbits. Entire text reviewed and updated by a leading expert, with major revision of therapeutics, anaesthesia, abscesses and neurology chapters. New clinical emphasis with clinical tips boxes throughout the text increase its practical focus Ancillary website presents clips of key procedures, an image library and podcasts Completely redesigned with more user-friendly text layout and full colour throughout. Many more illustrations specially commissioned for this edition

Security Technology Convergence Insights

Author: Ray Bernard

Publisher: Elsevier

Published: 2015-04-02

Total Pages: 160

ISBN-13: 0128030011

DOWNLOAD EBOOK →

Security technology convergence, which refers to the incorporation of computing, networking, and communications technologies into electronic physical security systems, was first introduced in the 1970s with the advent of computer-based access control and alarm systems. As the pace of information technology (IT) advances continued to accelerate, the physical security industry continued to lag behind IT advances by at least two to three years. Security Technology Convergence Insights explores this sometimes problematic convergence of physical security technology and information technology and its impact on security departments, IT departments, vendors, and management. Includes material culled directly from author's column in Security Technology Executive Easy-to-read question and answer format Includes real-world examples to enhance key lessons learned

Drug-Induced Liver Injury

Author:

Publisher: Academic Press

Published: 2019-07-13

Total Pages: 288

ISBN-13: 0128173173

DOWNLOAD EBOOK →

Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors

Author: Sir John R. Vane

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 249

ISBN-13: 9401090297

DOWNLOAD EBOOK →

In 1971, Vane proposed that the mechanism of action of the aspirin-like drugs was through their inhibition of prostaglandin biosynthesis. Since then, there has been intense interest in the interaction between this diverse group of inhibitors and the enzyme known as cyclooxygenase (COX). It exists in two isoforms, COX-l and COX-2 (discovered some 5 years ago). Over the last two decades several new drugs have reached the market based on COX-l enzyme screens. Elucidation of the three-dimensional structure of COX-l has provided a new understanding for the actions of COX inhibitors. The constitutive isoform of COX, COX-l has clear physiological functions. Its activation leads, for instance, to the production of prostacyclin which when released by the endothelium is anti-thrombogenic and anti-atherosclerotic, and in the gastric mucosa is cyto protective. COX-l also generates prostaglandins in the kidney, where they help to maintain blood flow and promote natriuresis. The inducible isoform, COX-2, was discovered through its activity being increased in a number of cells by pro inflammatory stimuli. A year or so later, COX-2 was identified as a distinct isoform encoded by a different gene from COX-I. COX-2 is induced by inflammatory stimuli and by cytokines in migratory and other cells. Thus the anti-inflammatory actions of non-steroid anti-inflammatory drugs (NSAIDs) may be due to the inhibition of COX-2, whereas the unwanted side-effects such as irritation of the stomach lining and toxic effects on the kidney are due to inhibition of the constitutive enzyme, COX-I.

Artificial Cells, Cell Engineering and Therapy

Author: S Prakash

Publisher: Elsevier

Published: 2007-05-31

Total Pages: 544

ISBN-13: 1845693078

DOWNLOAD EBOOK →

Artificial cells, cell engineering and therapy are emerging technologies which will make a significant impact on the future of medicine and healthcare. However, research within the field is vast. This unique book provides a comprehensive study of the most recent advances in the field and its practical applications. The first part of the book offers the reader an introduction to the basics of artificial cell technology with chapters on its origins, design, current status within medicine and future prospects. Part two covers apoptosis, the use of bone marrow stromal cells in myocardial regeneration together with signalling and tissue engineering. Part three discusses artificial cells for therapy, procedures for various clinical conditions and the current status of the discipline within the field. The book concludes with a final section on the role of artificial cells in medicine with particular focus on the use of artificial cells as blood substitutes and their potential use in myocardial regeneration, drug delivery and in treating kidney and bowel diseases, diabetes and cancer. Artificial cells, cell engineering and therapy is a valuable reference for researchers, students and practitioners within the field. Introduces the basics of artificial cell technology Provides a comprehensive study of the most recent advances in artificial cells, cell engineering and cell therapy Discusses the design, engineering and uses of artificial cells

Advances in Eicosanoid Research

Author: C.N. Serhan

Publisher: Springer Science & Business Media

Published: 2000-04-10

Total Pages: 286

ISBN-13: 9783540667476

DOWNLOAD EBOOK →

Over the last few years, we have witnessed tremendous progress in the field of eicosanoids and their therapeutic applications. Receptor an tagonists for leukotrienes have been tested as anti-inflammatories and are on the market as a treatment for asthma. Receptor agonists for pro stacyclin are being tested for the treatment of peripheral vascular dis ease, and selective inhibitors of cyclooxygenase type II were just ap proved for the treatment of rheumatoid arthritis. All these developments are the culmination of many years and man-hours of careful research. The field has now entered an upswing that will result in novel thera peutic applications within the next 10 years. New molecules and me diators have been identified, new enzymes and pathways elucidated and new therapeutic approaches have emerged. The concept of ei cosanoids as "pro-inflammatory" molecules is being challenged, and their role as regulators is increasingly recognized. In fact, some of these molecules may be important endogenous anti-inflammatory agents.

Selective COX-2 Inhibitors

Author: Sir John R. Vane

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 153

ISBN-13: 9401148724

DOWNLOAD EBOOK →

The mainstay of therapy for rheumatoid disease is the non-steroid antiinflammatory drugs (NSAIDs), despite their inherent gastrointestinal toxicity and ability to cause renal damage in susceptible patients. The theory that the beneficial and toxic effects of NSAIDs stem from a reduction in prostanoid production through inhibition of cyclooxygenase implied that particular toxicities were inevitable with NSAIDs and would always be correlated with efficacy. However, over the years, it became apparent that at therapeutic doses, some NSAIDs had greater toxic side-effects than others, a fact not explained by the general theory. A significant clarification arose from the discovery that there are two distinct isoforms of COX, a constitutive enzyme (COX-I) responsible for the production of prostanoids necessary for platelet aggregation and protection of the gastric mucosa and kidney; and an inducible enzyme (COX-2) that is newly synthesized at sites of tissue damage and produces prostaglandins that manifest pathological effects. It became clear that different NSAIDs had greater or lesser effects on COX-I when used in therapeutic doses, explaining the variation in side-effects. ' The elucidation of the crystal structure of these different enzymes and the skills of medicinal chemists have led to the synthesis of new chemicals with a selectivity for the inducible enzyme, and thus with therapeutic efficacy without those toxic effects result ing from inhibition of the constitutive enzyme.

Analytical Profiles of Drug Substances and Excipients

Author:

Publisher: Academic Press

Published: 1996-08-30

Total Pages: 619

ISBN-13: 9780080861197

DOWNLOAD EBOOK →

Although the official compendia define a drug substance as to identity, purity, strength, and quality, they normally do not provide other physical or chemical data, nor do they list methods of synthesis or pathways of physical or biological degradation and metabolism. Such information is scattered throughout the scientific literature and the files of pharmaceutical laboratories. Edited by the Associate Director of Analytical Research and Development for the AmericanAssociation of Pharmaceutical Scientists, Analytical Profiles of Drug Substances and Excipients brings this information together into one source. The scope of the series has recently been expanded to include profiles of excipient materials.