New insights into innate immune cell-based immunotherapies in cancer
Author: Mary Poupot-Marsan
Publisher: Frontiers Media SA
Published: 2024-04-17
Total Pages: 256
ISBN-13: 2832548040
DOWNLOAD EBOOK →Author: Mary Poupot-Marsan
Publisher: Frontiers Media SA
Published: 2024-04-17
Total Pages: 256
ISBN-13: 2832548040
DOWNLOAD EBOOK →Author: Rong-Fu Wang
Publisher: Springer Science & Business Media
Published: 2012-02-02
Total Pages: 476
ISBN-13: 1441999140
DOWNLOAD EBOOK →Innate and adaptive immunity play important roles in immunosurveillance and tumor destruction. However, increasing evidence suggests that tumor-infiltrating immune cells may have a dual function: inhibiting or promoting tumor growth and progression. Although regulatory T (Treg) cells induce immune tolerance by suppressing host immune responses against self- or non self-antigens, thus playing critical roles in preventing autoimmune diseases, they might inhibit antitumor immunity and promote tumor growth. Recent studies demonstrate that elevated proportions of Treg cells are present in various types of cancers and suppress antitumor immunity. Furthermore, tumor-specific Treg cells can inhibit immune responses only when they are exposed to antigens presented by tumor cells. Therefore, Treg cells at tumor sites have detrimental effects on immunotherapy directed to cancer.
Author: Joseph D. Rosenblatt
Publisher: Springer Science & Business Media
Published: 2013-10-25
Total Pages: 369
ISBN-13: 1461488095
DOWNLOAD EBOOK →Recent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. This includes new understanding of T- and B-cell interaction, immune inhibitory mechanisms including the biology of T regulatory cells, myeloid suppressor cells, and dendritic cell subsets. Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon response pathways, and NKG2D downregulation have all provided new insight into suppression of anti-tumor immunity and tumor evasion. In addition to emerging understanding of tumor evasion, new immune targets such as CTLA4 blockade, NK stimulatory receptors, manipulation of the antigen processing and presentation, cytokine and costimulatory responses all provide new possibilities for enhancing anti-tumor immunity even in tumors previously felt to be resistant to immune attack. Several of these strategies have already been realized in the clinic. The volume will explore evolving paradigms in antigen presentation, dendritic cell biology, the innate response and immunosuppressive mechanisms, and emerging strategies for manipulation of the immune system for therapeutic benefit that have realized success in neuroblastoma, leukemia, melanoma, lung cancer, and allogeneic transplantation. Early successes as well as failures will be highlighted to provide a snapshot of the state of clinical immunotherapy with an eye to future possibilities such as combination therapies, adoptive T-cell transfer, and the retargeting of immune cells via T-cell receptor engineering.
Author: Jérôme Paggetti
Publisher: Frontiers Media SA
Published: 2022-01-31
Total Pages: 164
ISBN-13: 2889742415
DOWNLOAD EBOOK →Author: Jérôme Paggetti
Publisher: Frontiers Media SA
Published: 2022-03-02
Total Pages: 191
ISBN-13: 2889742067
DOWNLOAD EBOOK →Topic Editor MS received funding from Bayer AG.
Author: Ahmed Lasfar
Publisher:
Published: 2020
Total Pages:
ISBN-13: 9781789851465
DOWNLOAD EBOOK →Author: Rajesh Uthamanthil
Publisher: Academic Press
Published: 2016-10-13
Total Pages: 486
ISBN-13: 0128040610
DOWNLOAD EBOOK →Patient Derived Tumor Xenograft Models: Promise, Potential and Practice offers guidance on how to conduct PDX modeling and trials, including how to know when these models are appropriate for use, and how the data should be interpreted through the selection of immunodeficient strains. In addition, proper methodologies suitable for growing different type of tumors, acquisition of pathology, genomic and other data about the tumor, potential pitfalls, and confounding background pathologies that occur in these models are also included, as is a discussion of the facilities and infrastructure required to operate a PDX laboratory. Offers guidance on data interpretation and regulatory aspects Provides useful techniques and strategies for working with PDX models Includes practical tools and potential pitfalls for best practices Compiles all knowledge of PDX models research in one resource Presents the results of first ever global survey on standards of PDX development and usage in academia and industry
Author: Suzanne L. Walker
Publisher:
Published: 2018-10
Total Pages:
ISBN-13: 9781635930184
DOWNLOAD EBOOK →Author: Pawel Kalinski
Publisher: Springer
Published: 2017-12-22
Total Pages: 271
ISBN-13: 331967577X
DOWNLOAD EBOOK →The tumor microenvironment has become a very important and hot topic in cancer research within the past few years. The tumor microenvironment is defined as the normal cells, molecules, and blood vessels that surround and feed a tumor cell. As many scientists have realized, studying the tumor microenvironment has become critical to moving the field forward, since there are many players in a tumor’s localized and surrounding area, which can significantly change cancer cell behavior. There is a dual relationship wherein the tumor can change its microenvironment and the microenvironment can affect how a tumor grows and spreads. Tumor Microenvironment in Cancer Progression and Cancer Therapy aims to shed light on the mechanisms, factors, and mediators that are involved in the cancer cell environment. Recent studies have demonstrated that in addition to promoting tumor progression and protecting tumor cells from the spontaneous immune-mediated rejection and different forms of cancer therapeutics, tumor microenvironment can also be a target and mediator of both standard and newly-emerging forms of cancer therapeutics. Thus, the dual role of the tumor microenvironment is the integral focus of the volume. The volume highlights the bi-directional interactions between tumor cells and non-malignant tumor component during tumor progression and treatment. It also focuses on the three groups of the reactive tumor component: stromal cells, blood vessels and the infiltrating immune cells. These three groups are discussed under the lens of their role in promoting tumor growth, shielding the tumor from rejection and from standard forms of cancer therapies. They are emerging as targets and mediators of standard and new forms of potential therapy.
Author: Patrick Ming-Kuen Tang
Publisher: Frontiers Media SA
Published:
Total Pages: 142
ISBN-13: 2832544754
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