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New Aspects of CMV-related Immunopathology

Author: Susanna Prösch

Publisher: Karger Medical and Scientific Publishers

Published: 2003-01-01

Total Pages: 222

ISBN-13: 3805576188

Cytomegalovirus (CMV) infection causes severe diseases in immunocompromised patients. CMV-related morbidity is frequently linked to aberrant immune responses occurring locally within the respective tissues including immune-privileged sites such as the retina. There is growing evidence that CMV-related pathomechanisms differ profoundly as a function of cell type and differentiation state of the host cell. This book provides important new insights into CMV-related immunopathology, discusses molecular mechanisms involved in HCMV-mediated tissue injury, CMV latency and reactivation, and presents novel ideas and concepts to develop alternative antiviral drugs. As an important focus, the role of CMV-reactive T cells in protection, pathogenesis, diagnosis and therapy of HCMV infection is discussed. The contributions to this book are written by leading scientists and clinicians in the field of CMV who participated in the fourth international meeting on CMV-related immunopathology, held in Berlin, September 2002. Comprehensive and up-to-date, this volume is a vital reference for clinicians involved in the diagnosis and treatment of CMV infections, as well as for researchers working in the field of herpesvirus biology and the development of antiviral drugs.

New Aspects of CMV-Related Immunopathology

Author: J. Cinatl

Publisher:

Published: 2003

Total Pages: 0

ISBN-13: 9783318010060

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CMV-related Immunopathology

Author: Martin Scholz

Publisher: Karger Medical and Scientific Publishers

Published: 1998

Total Pages: 321

ISBN-13: 3805566026

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'This monograph will appeal to clinical microbiologists, and virologists involved in the care of transplant recipients and AIDS patients, as it provides the scientific basis of antiviral drug activity, molecular diagnosis and also of possible immunopathogenic mechanisms of CMV disease and CMV-related graft rejection.... it is highly recommended.'

CMV-Related Immunopathology

Author: M. Scholz

Publisher:

Published: 1997

Total Pages: 0

ISBN-13: 9783318002621

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Cytomegalovirus (CMV) infection can cause severe diseases with significant morbidity and mortality in immunocompromised patients such as bone marrow or solid-organ transplant recipients, and AIDS patients. Major manifestations include transplant rejection, hepatitis, pneumonitis, encephalitis and retinitis. There is growing evidence that in certain cases CMV disease is closely linked to aberrant immune responses occurring locally within the respective tissues. This book provides important new insights into CMV-related immunopathology, discusses current methods of CMV diagnosis and anti-CMV therapy, and proposes novel antiviral treatment strategies. It contains contributions by leading scientists and clinicians in the field of CMV, who participated in the 'First International Round Table Consensus Meeting', held in Frankfurt, Germany, in August 1997. Comprehensive and up-to-date, this volume is a vital reference for clinicians involved in the diagnosis and treatment of CMV infections, as well as for researchers working on herpesvirus biology and the development of antiviral drugs.

Novel Immunological Aspects of CMV-Related Diseases

Author: Cathrien A. Bruggeman

Publisher: S. Karger AG (Switzerland)

Published: 2000

Total Pages: 158

ISBN-13: 9783805570497

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This special issue contains contributions by leading scientists and clinicians in the field of CMV, who participated in the 2nd Symposium on CMV-Related Immunopathology, held in Maastricht, Netherlands, in September 1999. Recent research has shown that cytomegalovirus manipulates the immune system in an obviously 'intelligent' way to promote virus persistence, replication and dissemination. This manipulation leads to aberrant host immune responses and to disease in immunocompromised persons such as transplant recipients or AIDS patients. However, there is growing evidence that CMV-related immunopathomechanisms may also be of significance in adult non-immunocompromised people, even in the absence of detectable viremia. Reflecting and interpreting the most up-to-date information available on CMV-related immunopathology and anti-CMV therapy, this publication will be of vital interest for clinicians involved in the diagnosis and treatment of CMV infections as well as for researchers working on herpesvirus biology and the development of antiviral drugs.

SARS, MERS and other Viral Lung Infections

Author: David S. Hui

Publisher: European Respiratory Society

Published: 2016-06-01

Total Pages: 148

ISBN-13: 1849840709

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Viral respiratory tract infections are important and common causes of morbidity and mortality worldwide. In the past two decades, several novel viral respiratory infections have emerged with epidemic potential that threaten global health security. This Monograph aims to provide an up-to-date and comprehensive overview of severe acute respiratory syndrome, Middle East respiratory syndrome and other viral respiratory infections, including seasonal influenza, avian influenza, respiratory syncytial virus and human rhinovirus, through six chapters written by authoritative experts from around the globe.

Human Milk for Preterm Infants, An Issue of Clinics in Perinatology, E-Book

Author: Francis B. Mimouni

Publisher: Elsevier Health Sciences

Published: 2017-02-06

Total Pages: 297

ISBN-13: 0323510027

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Dr. Mimouni and Dr. Koletzko have assembled some of the world's leaders on breast milk for preterm infants to provide a current overview of the benefits and barriers. Authors address the following topics: Preterm human milk macronutrient composition; Bed-side human milk analysis in the NICU; Human milk fortification; DHA supplements; Potential benefits of bioactive proteins in human milk for preterm infants; New insights into variations of metabolite and hormone contents in human milk; Immune properties of human milk in relation to preterm infant feeding; Human milk oligosaccharides; Treatment and quality of banked human milk; Use of donor milk: collection, storage and safety; Postnatal CMV infection through human milk in preterm infants: Transmission, clinical presentation, and prevention; NEC and human milk feeding; Neurodevelopmental outcomes of preterm infants fed human milk; Evidence-based methods that promote human milk feeding of preterm infants; and Human flavor learning: the breastfeeding experience. Lactiation consultants, NICU nurses, and neonatologists will find these clinical review articles to be very valuable.

Chimpanzees in Biomedical and Behavioral Research

Author: National Research Council

Publisher: National Academies Press

Published: 2011-12-05

Total Pages: 200

ISBN-13: 0309220424

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For many years, experiments using chimpanzees have been instrumental in advancing scientific knowledge and have led to new medicines to prevent life-threatening and debilitating diseases. However, recent advances in alternate research tools have rendered chimpanzees largely unnecessary as research subjects. The Institute of Medicine, in collaboration with the National Research Council, conducted an in-depth analysis of the scientific necessity for chimpanzees in NIH-funded biomedical and behavioral research. The committee concludes that while the chimpanzee has been a valuable animal model in the past, most current biomedical research use of chimpanzees is not necessary, though noted that it is impossible to predict whether research on emerging or new diseases may necessitate chimpanzees in the future.

Human Cytomegalovirus

Author: Thomas E. Shenk

Publisher: Springer Science & Business Media

Published: 2008-05-09

Total Pages: 477

ISBN-13: 3540773495

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This volume has gathered some of the experts in the field to review aspects of our understanding of CMV and to offer perspectives of the current problems associated with CMV. The editors and authors hope that the chapters will lead to a better understanding of the virus that will assist in the development of new and unique antivirals, a protective vaccine, and a full understanding of CMV's involvement in human disease.

Human Herpesviruses

Author: Ann Arvin

Publisher: Cambridge University Press

Published: 2007-08-16

Total Pages: 1325

ISBN-13: 1139461648

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This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.