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New Approaches to Natural Anticancer Drugs

Author: Soodabeh Saeidnia

Publisher: Springer

Published: 2015-02-05

Total Pages: 117

ISBN-13: 3319140272

This book provides an up-to-date review of recently identified natural anti-tumor compounds from various natural origins including plants, fungi, endophytic fungi and marine organisms. It also includes discussion of new areas such as biotechnology and nanoparticles. Chapters explain the challenges and developments in anti-cancer drug discovery approaches, traditional remedies for prevention and treatment of cancer, marine-derived anti-cancer compounds, and antibiotics used as anti-cancer agents, as well as different classes of terpenoids and carbohydrates, which have been the subject of discussion in this field as efficient anti-cancer candidates. This book will be a concise guide for researchers in the field of pharmaceutical sciences, students and residents in pharmacy and medicine as well as those researching phytochemistry and natural products.

Natural Products and Cancer Drug Discovery

Author: Frank E. Koehn

Publisher: Springer Science & Business Media

Published: 2012-11-09

Total Pages: 248

ISBN-13: 1461446546

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This volume will cover the natural products as they relate to cancer chemotherapy. The topics will include history and current status , recent launches, new clinical candidates and approved drugs directly derived from natural products, current and future cancer target opportunities for natural products, leveraging natural products as tools for new target generation , new approaches to cancer drug discovery through natural products based lead generation, and enabling technologies which leverage the unique attributes of natural products.

Anticancer Agents from Natural Products, Second Edition

Author: Gordon M. Cragg

Publisher: CRC Press

Published: 2011-10-10

Total Pages: 786

ISBN-13: 1439813825

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The approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natural product may not be an effective drug for any of several reasons, but it nevertheless may become a drug through chemical modification or have a novel pharmacophore for future drug design. In summarizing the status of natural products as cancer chemotherapeutics, Anticancer Agents from Natural Products, Second Edition covers the: History of each covered drug—a discussion of its mechanism on action, medicinal chemistry, synthesis, and clinical applications Potential for novel drug discovery through the use of genome mining as well as future developments in anticancer drug discovery Important biosynthetic approaches to "unnatural" natural products Anticancer Agents from Natural Products, Second Edition discusses how complex target-oriented synthesis—enabled by historic advances in methodology—has enormously expanded the scope of the possible. This book covers the current clinically used anticancer agents that are either natural products or are clearly derived from natural product leads. It also reviews drug candidates currently in clinical development since many of these will be clinically used drugs in the future. Examples include the drugs etoposide and teniposide derived from the lead compound podophyllotoxin; numerous analogs derived from taxol; topotecan, derived from camptothecin; and the synthetic clinical candidates, E7389 and HTI-286, developed from the marine leads, halichondrin B and hemiasterlin.

Alternative Remedies and Natural Products for Cancer Therapy: An Integrative Approach

Author: Motamarri Venkata Naga Lalitha Chaitanya

Publisher: Bentham Science Publishers

Published: 2023-11-02

Total Pages: 325

ISBN-13: 9815124706

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This book provides a holistic view of natural products and remedies that have been used to treat cancer. The editors aim to educate readers about the importance of the translational role of natural products in cancer treatment by compiling 14 chapters. The book emphasizes an integrative approach to the topic by blending traditional knowledge that supports alternative therapies with the science of phytochemicals and drug discovery technologies as a means to manage the disease. Key topics include alternative therapies (such as aromatherapy and immune boosting herbal medications), cytotoxic and anti-cancer phytochemicals, drug delivery and discovery technologies (including high-throughput screening) and some drug targets of interest for cancer treatment (such as topoisomerases and caspases). Readers will be able to learn about natural sources of ant-cancer compounds, and the methods used by research and development experts in pharmaceutical and nutraceutical industries to isolate and formulate these compounds. This book will be a handy resource for a wide range of readers. This includes researchers, traditional medical practitioners, PG students, Ph.D. scholars and general readers to understand the role of natural products in cancer treatment. key features - Explains the importance of alternative therapies in the management of cancer - Emphasizes the ethnopharmacological approaches to cancer - Explores natural anticancer drug libraries - Discusses the role of modern cancer targets and the importance of in-silico tools in anticancer drug discovery - Addresses modern drug discovery tools and drug delivery technologies concerning their applications in cancer treatment. - Includes references for further reading

Anticancer Drug Discovery and Development: Natural Products and New Molecular Models

Author: Frederick A. Valeriote

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 289

ISBN-13: 1461526108

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With the publication of these proceedings from the Second Drug Discovery and Development Symposium, this forum has become the main mechanism for bringing together the principal groups involved in both discovering and developing new approaches to the treatment of cancer. This Second Symposium emphasized the types of materials being discovered and their therapeutic activity. This is especially evident in the natural product discovery programs, where unique and active structures are being identified. The major contributors to the meeting were the investigators participating in the National Cooperative (Natural Products) Drug Discovery Groups [NC(NP)DDG]. These groups reflect an association among researchers at universities or cancer centers, pharmaceutical companies and the National Cancer Institute. Their sources of materials are varied, reflecting chemical inventories of pharmaceutical companies, organic synthetic compounds from the laboratory, cytotoxics as well as biologics and their hybrids, and natural products obtained from plants, marine organisms and microorganisms. The models employed in the discovery systems vary from broadly cellular based to specific enzymes to defined cellular functions. Each of them is believed important to the malignant state and will allow for the discovery of compounds which will have efficacy in cancer therapy. The goal of the participants is both to discover new anticancer agents and to develop them as efficiently as possible into clinically useful additions to treatment. Of importance is the fact that there are a number of promising leads which will soon be moving into the clinic thereby testing the effectiveness of this NC (NP) DDG approach.

Natural Products for Cancer Prevention and Therapy

Author: Anupam Bishayee

Publisher: MDPI

Published: 2018-11-07

Total Pages: 285

ISBN-13: 3038973106

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This book is a printed edition of the Special Issue "Natural Products for Cancer Prevention and Therapy" that was published in Nutrients

Anticancer Agents from Natural Products

Author: Gordon M. Cragg

Publisher: CRC Press

Published: 2005-06-13

Total Pages: 610

ISBN-13: 1420039652

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Plants, marine organisms, and microorganisms have evolved complex chemical defense and signaling systems that are designed to protect them from predators and provide other biological benefits. These organisms thus produce substances containing novel chemotypes that may have beneficial effects for humans. As collection methods improve and new screen

Natural Products and Cancer Drug Discovery

Author: Farid A. Badria

Publisher: BoD – Books on Demand

Published: 2017-07-05

Total Pages: 318

ISBN-13: 9535133136

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This book, Natural Products and Cancer Drug Discovery, is written by leading experts in natural products in cancer therapy. The first two sections describe new applications of common herbs and foods for treatment of cancer. Section 3 deals with the development of new chemotherapeutics from Cannabis and endophytic fungi. Section 4 presented formulations of natural products for treatment of malignant melanoma. Made-to-order anticancer therapy from natural products using computational and tissue engineering approaches is addressed in the fifth section. It is our hope that this book may motivate readers to approach the evidence of anticancer natural products with an open mind and thereby spark an interest in making further contributions to the cancer treatment efforts.

Cancer Drug Resistance

Author: Beverly A. Teicher

Publisher: Springer Science & Business Media

Published: 2007-11-09

Total Pages: 611

ISBN-13: 1597450359

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Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.

Anticancer Drugs

Author: Garth Powis

Publisher: Elsevier Science & Technology

Published: 1994

Total Pages: 532

ISBN-13:

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There are over 50 clinically approved anticancer drugs, as well as numerous steroidal agents, and in addition there are many new anticancer drugs in various stages of preclinical and clinical development. The anticancer drugs embody a diverse array of chemical structures. The purpose of this two volume publication is to provide a comprehensive review of the metabolism of anticancer drugs. The authors, each expert in their fields, have attempted to emphasize the relation of metabolism to the therapeutic and toxic effects of anticancer drugs, drawing whenever possible on human studies. There is a critical need for new approaches to treating cancer and it is certain that we will see an increasing number of new drugs with exotic chemical structures used for chemotherapy and perhaps chemoprevention. To understand the mechanisms of action of any drug it is important to know how the drug is transformed in the body, either into active metabolites or inactive products to be excreted. With this information the success or failure of a drug in arresting cancer cell growth can be assessed, and perhaps more effective drugs designed. Medical science has taken the first important steps toward controlling cancer. The use and study of current chemotherapeutic drugs has taught us much about how toxic chemicals can be employed to treat human cancer; comprehending the underlying metabolism of these drugs should facilitate even better modalities of treatment for the future.