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Neuropeptides

Author: Fleur L. Strand

Publisher: MIT Press

Published: 1999

Total Pages: 678

ISBN-13: 9780262194075

This textbook is the first to bring together and synthesize the neuropeptide research of the past decade in such a comprehensive, scholarly manner. In recent years there has been increasing interest and, subsequently, active research in neuropeptides. These neuroactive molecules coordinate, integrate, and regulate physiological processes in all organisms, throughout all phases of development. Acting as neurohormones, neurotransmitters, and/or neuromodulators, they maintain physiological homeostasis and influence important behavioral patterns. This textbook is the first to bring together and synthesize the neuropeptide research of the past decade in such a comprehensive, scholarly manner. The book is divided into two parts. In Part I the author defines the basic principles of neuropeptide action, including their biosynthesis, processing, transport, distribution, and interactions with receptors and second messenger systems. Strand also discusses the intimate interaction between the neuropeptides, stress, and the immune system. In Part II she discusses the regulatory functions of the families of neuropeptide in sufficient detail to provide both the advanced student and senior investigator with a thorough understanding of the most important neuropeptides. The text also contains a complete and up-to-date reference/reading list.

Neuropeptides and Other Bioactive Peptides

Author: Lloyd D. Fricker

Publisher: Morgan & Claypool Publishers

Published: 2012

Total Pages: 123

ISBN-13: 1615045066

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Neuropeptides and peptide hormones represent the largest class of chemical messengers that transmit information from one cell to another. In this review, several decades of research on peptides in cell-cell signaling are summarized, with a focus on neuropeptide discovery, biosynthesis, and function. In addition to covering the well-studied aspects of neuropeptides, emerging concepts are discussed, including classical versus non-classical neuropeptides and direct versus indirect neuropeptides. Other potential functions for peptides in intercellular and intracellular signaling are also discussed. Table of Contents: Overview of Neuropeptides / Neuropeptide Discovery / Neuropeptide Biosynthesis / Neuropeptides After Secretion: Receptors and Peptidases / Representative Neuropeptides / Concluding Remarks and Future Directions / References / Author Biography

Neuropeptides

Author: Jacqueline N. Crawley

Publisher:

Published: 1996

Total Pages: 280

ISBN-13:

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This volume highlights the most recent discoveries in the genetics, biochemistry, biology, pharmacology and clinical aspects of neuropeptide research.

Neuropeptides in Neuroprotection and Neuroregeneration

Author: Fred Nyberg

Publisher: CRC Press

Published: 2012-06-19

Total Pages: 321

ISBN-13: 1439830622

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Although the genomic era is no longer in its infancy, the life sciences are still facing questions about the role of endogenous proteins and peptides in homeostasis and pathologies. Delving into one of the most current fields of interest in biology and medicine, Neuropeptides in Neuroprotection and Neuroregeneration describes the impact of neuropeptides on neuroprotection and neuroregeneration. The book begins with chapters describing important features of the endogenous neuropeptide systems related to their formation, receptor signaling, and inactivation. It includes chapters focused on the design and development of peptide-like drugs (peptidomimetics). In addition, the book covers: General aspects regarding the biosynthesis, structures, and distribution of neuroactive peptides and their receptors Basic mechanisms for neuropeptide action, metabolism, as well as techniques for their detection and aspects essential for the cellular mechanisms underlying brain pathology Neuropeptides known for their impact in neurodegenerative and neuroprotective processes Fundamental aspects as well as recent progress in the development of peptidomimetics of neuroprotective and cognition-enhancing peptides

Neuropeptides in the Spinal Cord

Author: F. Nyberg

Publisher: Elsevier

Published: 1995

Total Pages: 439

ISBN-13: 0444817190

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This is the first book devoted exclusively to examining the role of neuropeptides in the spinal cord. Great progress has been made recently in our understanding of the role of neuropeptides in neurotransmission. New tools have been developed to help study the function of endogenous neuropeptides in health and disease. Because the general organization of the spinal cord is well conserved among species and neuropeptides appear to have a major role in spinal neurotransmission, this book is a timely compendium of recent research in this field. The volume will help to stimulate further research in the field of neuropeptides which will lead to better understanding of this role in health and disease.

Neuropeptides in Development and Aging

Author: Bill E. Beckwith

Publisher:

Published: 1997

Total Pages: 406

ISBN-13:

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This work focuses on the influence of neuropeptides on development throughout the life span. It has become increasingly apparent that the central nervous system is not a passive entity determined by either environment or heredity. Rather, the brain appears to interact with its environment throughout early and later development, and thus contributes to its own structural and functional systems. This work describes the role neuropeptides play in this process.

Neuropeptides and Brain Function

Author:

Publisher: Elsevier

Published: 2011-09-22

Total Pages: 343

ISBN-13: 0080861970

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Neuropeptides and Brain Function

Neuropeptide Receptors

Author: Ivone Gomes

Publisher: Biota Publishing

Published: 2013-04-01

Total Pages: 169

ISBN-13: 1615044698

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Neuropeptides mediate their effects by binding and activating receptors that are responsible for converting these extracellular stimuli into intracellular responses. Most neuropeptides interact with G protein-coupled receptors that transduce the signal by activating heterotrimeric G proteins leading to alterations in second messenger systems to amplify the signal and elicit the intracellular response. In this review, we describe the general structure of G protein-coupled receptors including the information obtained from crystal structure determination that has given an insight into the activation mechanism of these receptors. In addition, we summarize the components of the signal transduction system (including G proteins, effectors and second messengers generally activated by the neuropeptide receptors). Using select examples of neuropeptide-receptor systems, we highlight the neuropeptides and corresponding receptors involved in modulation of pain and analgesia, body weight regulation, and hormonal regulation. Finally, we discuss the enzyme-linked tyrosine kinase receptors activated by growth factors and discuss the emerging concepts in targeting neuropeptide receptors for the identification of novel therapeutics targeting these systems. Table of Contents: Abbreviations / Overview of Neuropeptide Receptors / G Protein-Coupled Receptors: General Structure & Function / G Protein-Coupled Receptor Signaling / Neuropeptide Processing and Regulation / Neuropeptide Receptors / Perspectives / References

The Evolution of Neuropeptides – A Stroll Through the Animal Kingdom: Updates from the Ottawa 2019 ICCPB Symposium and Beyond

Author: Klaus H. Hoffmann

Publisher: Frontiers Media SA

Published: 2020-09-17

Total Pages: 163

ISBN-13: 2889660176

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Brain Functions of Neuropeptides: A Current View

Author: J.P.H. Burbach

Publisher: CRC Press

Published: 1993-05-15

Total Pages: 156

ISBN-13: 9781850704539

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Brain Functions of Neuropeptides contains capita selecta on neuropeptides by leading scientists in the neurosciences. As a guide through the wealth of neuropeptide research, the authors here present current and personal views on the roles that neuropeptide functions have in the nervous ystem, and their mode of action. The authors address an audience that includes readers at the undergraduate level in life sciences, but also experts who are intersted in timely issues.