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Neuronal Input Pathways to the Brain's Biological Clock and their Functional Significance

Author: Jens Hannibal

Publisher: Springer Science & Business Media

Published: 2006-06-07

Total Pages: 84

ISBN-13: 3540277897

Rhythmic changes in physiology and behaviour within a 24 h period occur in living organisms on earth to meet the challenges associated with the daily changes in the external environment. The circadian pacemaker responsible for the temporal internal organisation and the generation of endogenous rhythms of approximately 24 h is located in the hypothalamic suprachiasmatic nucleus (SCN) in mammals. The endogenous period generated by the pacemaker is close to, but generally not equal to 24 h and the biological clock therefore needs to be daily adjusted (entrained) by external cues. The daily alteration of light and darkness due to the rotation of our planet on its own axis in relation to the sun is the most prominent "zeitgeber" which adjusts the phase of the circadian rhythms to the astronomical day length, a process known as photoentrainment. In mammals, light is perceived only through photoreceptors located in the retina. Light information is mediated to the SCN via the retinohypothalamic tract (RHT) by activation of the classical photoreceptor system of rods and cones and a more recently identified system of intrinsic photosensitive retinal ganglion cells (ipRGCs) using melanopsin as a photopigment.

Human Circadian Physiology

Author: Charles A. Czeisler

Publisher:

Published: 1978

Total Pages: 692

ISBN-13:

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The Neurobiology of Circadian Timing

Author:

Publisher: Elsevier

Published: 2012-12-06

Total Pages: 513

ISBN-13: 044459454X

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Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future researchChapters are extensively referenced to provide readers with a comprehensive list of resources on the topics coveredAll chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Sleep Disorders and Sleep Deprivation

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2006-10-13

Total Pages: 425

ISBN-13: 0309101115

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Clinical practice related to sleep problems and sleep disorders has been expanding rapidly in the last few years, but scientific research is not keeping pace. Sleep apnea, insomnia, and restless legs syndrome are three examples of very common disorders for which we have little biological information. This new book cuts across a variety of medical disciplines such as neurology, pulmonology, pediatrics, internal medicine, psychiatry, psychology, otolaryngology, and nursing, as well as other medical practices with an interest in the management of sleep pathology. This area of research is not limited to very young and old patientsâ€"sleep disorders reach across all ages and ethnicities. Sleep Disorders and Sleep Deprivation presents a structured analysis that explores the following: Improving awareness among the general public and health care professionals. Increasing investment in interdisciplinary somnology and sleep medicine research training and mentoring activities. Validating and developing new and existing technologies for diagnosis and treatment. This book will be of interest to those looking to learn more about the enormous public health burden of sleep disorders and sleep deprivation and the strikingly limited capacity of the health care enterprise to identify and treat the majority of individuals suffering from sleep problems.

GABA and Sleep

Author: Jaime M. Monti

Publisher: Springer Science & Business Media

Published: 2010-09-28

Total Pages: 501

ISBN-13: 303460226X

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GABA (gamma-aminobutyric acid) is the main neurotransmitter regulating sleep. The majority of drugs presently in use for the treatment of sleep disorders act by enhancing GABAergic neuronal inhibition. The GABA system is, therefore, of prime clinical relevance for the therapy of insomnia. The focus of this volume is on the neuropsychopharmacology and the clinical impact of the GABA system in regulating sleep and wakefulness. It presents molecular, neuropharmacological, systems-biological and clinical approaches to the understanding of the mechanism of action of GABA and GABAergic drugs. It also explores the role of GABA in the basic drives that affect sleep, and the influences that adapt sleep and wakefulness to external events.

Circadian Clocks

Author: Tsuyoshi Hirota

Publisher: Springer Nature

Published: 2022-09-15

Total Pages: 432

ISBN-13: 1071625772

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This volume provides backgrounds, methods, and troubleshooting for the analysis of circadian rhythms at the molecular, cellular, and organismal levels in vertebrates and invertebrates, and also covers light input, sleep, circalunar rhythms, and seasonal rhythms. The chapters in this book discuss behavioral and biological testing, histochemistry, single-cell imaging, electrophysiology, photochemistry, genetics, genomics, transcriptomics, proteomics, metabolomics, systems biology, chemical biology, and mathematical modeling. In the Neuromethods series style, chapters include experimental detail and key advice from the specialists needed to successfully carry out these methods in your laboratory. Cutting-edge and practical, Circadian Clocks is a valuable resource for all researchers seeking to learn about established and novel methods in chronobiology, and the molecular mechanisms of the rhythmic control of physiology and behavior.

Photobiology

Author: Lars Olof Björn

Publisher: Springer Science & Business Media

Published: 2007-12-26

Total Pages: 695

ISBN-13: 0387726551

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Since the publication of the first edition in 2002, there has been an explosion of new findings and applications in the field of photobiology. This brand new edition is fully updated, includes new references, and offers five new chapters for a comprehensive look at photobiology. The chapters cover all areas of photobiology, photochemistry, and the relationship between light and biology. The book starts with the physics and chemistry of light and then deals with the evolution of photosynthesis. Four chapters deal with how organisms use light for their orientation in space and time. There are also several medically oriented chapters and two chapters specifically aimed at the photobiology educator.

The Neurobiology of Circadian Timing

Author: A. Kalsbeek

Publisher: Elsevier

Published: 2012-09-21

Total Pages: 514

ISBN-13: 0444594272

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Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

International Review of Cytology

Author: Kwang W. Jeon

Publisher: Elsevier

Published: 2006-07-31

Total Pages: 281

ISBN-13: 0080464815

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International Review of Cytology presents current advances and comprehensive reviews in cell biology – both plant and animal. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Articles in this volume address roles of PACAP-containing retinal ganglion cells in circadian timing; cell polarity in filamenous fungi; cellular and molecular mechanics of gliding locomotion in eukaryotes; current strategies in overcoming resistance of cancer cell and apoptosis; cell and molecular biology of the exosome: how to make of break an RNA; human hair keratin associated proteins (KAPs).

Seasonal Affective Disorder

Author: Timo Partonen

Publisher: Oxford University Press

Published: 2010

Total Pages: 370

ISBN-13: 019954428X

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Seasonal affective disorder (SAD), or winter depression, is a mood disorder related to the change in the seasons and lack of exposure to daylight. It affects 1 in 100 adults in western countries. SAD is a rare example of a psychiatric disorder with a clear, identifiable biological cause. The new edition of this award winning book brings together distinguished scientists and opinion leaders to discuss the current and anticipated developments in the study and care of Seasonal Affective Disorder. Highlighting the clinical diagnosis and management of Seasonal Affective Disorder (SAD), this book provides a valuable resource for all whom are involved in the health care for patients with SAD. This book deals with the range of therapeutic measures that are available for the treatment of SAD. In addition, this book elucidates potential areas of research that have emerged such as the study of the circadian pacemaker and the night-time sleep structure and their interaction that influences mood.