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Neurological Modulation of Sleep

Author: Ronald Ross Watson

Publisher: Academic Press

Published: 2020-01-15

Total Pages: 432

ISBN-13: 0128166592

Neurological Modulation of Sleep provides readers with updated scientific reviews regarding the interaction between sleep and contributing factors, with special attention paid to the potential for neurological modulation of sleep via diet. This book expands the notion of diet and adds an element of physical activity and exercise as well as a chapter on caffeine and its effects on sleep. With 30+ international contributors, this book aims to provide readers with a unique global perspective on the role these factors plays in sleep architecture and its regulation by circadian biology and neurology. Sleep disorders have become an increasing problem plaguing more than 70 million Americans according to the American Sleep Association. There is a clear association between sleep disorder and a wide range of other human disorders –performance deficiencies, psychiatric illnesses, heart disease, obesity and more – but in spite of this there is not yet a convenient overview on the market detailing the impact of obesity, age, diabetes and diet on sleep duration and attendant health outcomes. Describes the impact of diet, caffeine and physical activity on sleep Reviews the neurology and metabolism of sleep Identifies what foods impact sleep and how Discusses the clinical use of nutraceuticals to improve sleep

Modulation of Sleep by Obesity, Diabetes, Age, and Diet

Author: Ronald Ross Watson

Publisher: Academic Press

Published: 2014-09-14

Total Pages: 405

ISBN-13: 0124202403

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Sleep disorder is a rampant problem in the US, with over 40 million Americans currently diagnosed according to the NIH. There is a clear association between sleep disorder and a wide range of other human disorders –performance deficiencies, psychiatric illnesses, heart disease, obesity and more – but in spite of this there is not yet a convenient overview on the market detailing the impact of obesity, age, diabetes and diet on sleep duration and attendant health outcomes. This volume focuses on the interaction between sleep and these factors, with special attention being paid to the potential for neurological modulation of sleep via diet. The volume aid readers in understanding the role each of these factors plays in sleep architecture and its regulation by circadian biology and neurology. Aids in understanding the impact of age, diet, obesity and disease on sleep Offers focus on neurological changes that affect metabolism Explores diabetes induced sleep problems Aid to understanding the multifactorial causes of age-related sleep dysfunction Addresses selected studies of nutraceuticals affecting sleep for potential application clinically Discusses major impact on sleep disorders by caffeine and alcohol

Neuroimaging of Sleep and Sleep Disorders

Author: Eric Nofzinger

Publisher: Cambridge University Press

Published: 2013-03-07

Total Pages: 445

ISBN-13: 1107018633

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An up-to-date, superbly illustrated practical guide to the effective use of neuroimaging in the patient with sleep disorders. The only book to date to provide comprehensive coverage of this topic. A must for all healthcare workers interested in understanding the causes, consequences and treatment of sleep disorders.

Modulation of Sleep by Obesity, Diabetes, Age, and Diet

Author: Ronald Ross Watson

Publisher: Academic Press

Published: 2016-09-02

Total Pages: 408

ISBN-13: 9780128103074

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Sleep disorder is a rampant problem in the US, with over 40 million Americans currently diagnosed according to the NIH. There is a clear association between sleep disorder and a wide range of other human disorders performance deficiencies, psychiatric illnesses, heart disease, obesity and more but in spite of this there is not yet a convenient overview on the market detailing the impact of obesity, age, diabetes and diet on sleep duration and attendant health outcomes. This volume focuses on the interaction between sleep and these factors, with special attention being paid to the potential for neurological modulation of sleep via diet. The volume aid readers in understanding the role each of these factors plays in sleep architecture and its regulation by circadian biology and neurology. Aids in understanding the impact of age, diet, obesity and disease on sleep Offers focus on neurological changes that affect metabolism Explores diabetes induced sleep problems Aid to understanding the multifactorial causes of age-related sleep dysfunction Addresses selected studies of nutraceuticals affecting sleep for potential application clinically Discusses major impact on sleep disorders by caffeine and alcohol "

Hypocretins

Author: Luis De Lecea

Publisher: Springer Science & Business Media

Published: 2007-04-25

Total Pages: 438

ISBN-13: 0387254463

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The first report that rapid eye movements occur in sleep in humans was published in 1953. The research journey from this point to the realization that sleep consists of two entirely independent states of being (eventually labeled REM sleep and non-REM sleep) was convoluted, but by 1960 the fundamental duality of sleep was well established including the description of REM sleep in cats associated with “wide awake” EEG patterns and EMG suppression. The first report linking REM sleep to a pathology occurred in 1961 and a clear association of sleep onset REM periods, cataplexy, hypnagogic hallucinations and sleep paralysis was fully established by 1966. When a naïve individual happens to observe a full-blown cataplexy attack, it is both dramatic and unnerving. Usually the observer assumes that the loss of muscle tone represents syncope or seizure. In order to educate health professionals and the general public, Christian Guilleminault and I made movies of full-blown cataplectic episodes (not an easy task). We showed these movies of cataplexy attacks to a number of professional audiences, and were eventually rewarded with the report of a similar abrupt loss of muscle tone in a dog. We were able to bring the dog to Stanford University and with this as the trigger, we were able to develop the Stanford Canine Narcolepsy Colony. Breeding studies revealed the genetic determinants of canine narcolepsy, an autosomal recessive gene we termed canarc1. Emmanuel Mignot took over the colony in 1986 and began sequencing DNA, finally isolating canarc1 in 1999.

Sleep Disorders and Sleep Deprivation

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2006-10-13

Total Pages: 425

ISBN-13: 0309101115

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Clinical practice related to sleep problems and sleep disorders has been expanding rapidly in the last few years, but scientific research is not keeping pace. Sleep apnea, insomnia, and restless legs syndrome are three examples of very common disorders for which we have little biological information. This new book cuts across a variety of medical disciplines such as neurology, pulmonology, pediatrics, internal medicine, psychiatry, psychology, otolaryngology, and nursing, as well as other medical practices with an interest in the management of sleep pathology. This area of research is not limited to very young and old patientsâ€"sleep disorders reach across all ages and ethnicities. Sleep Disorders and Sleep Deprivation presents a structured analysis that explores the following: Improving awareness among the general public and health care professionals. Increasing investment in interdisciplinary somnology and sleep medicine research training and mentoring activities. Validating and developing new and existing technologies for diagnosis and treatment. This book will be of interest to those looking to learn more about the enormous public health burden of sleep disorders and sleep deprivation and the strikingly limited capacity of the health care enterprise to identify and treat the majority of individuals suffering from sleep problems.

The Orexin System. Basic Science and Role in Sleep Pathology

Author: M.A. Steiner

Publisher: Karger Medical and Scientific Publishers

Published: 2021-05-28

Total Pages: 165

ISBN-13: 3318068446

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The orexin system, discovered in 1998, has emerged as a crucial player in regulating the sleep and wake balance inside our brain. This discovery has sparked a burst of novel and dynamic research on the physiology and pathology of sleep. The Orexin System: Basic Science and Role in Sleep Pathology honors this research and the authors share their ideas and perspectives on the novel developments within the field. The book examines the intricate role of the orexin system in regulating sleep and wake, and its interaction with other wake-regulating systems. The orexin system is dissected at the cellular and molecular level to explore the diversity of the orexin-producing neurons, their projections, and their signaling pathways. Additionally, the book discusses the diseases which are associated with a dysfunctional orexin system, such as narcolepsy, insomnia, substance abuse, and Alzheimer’s disease, and explores the new potential therapeutic applications derived from the burst of research around this fascinating system. This publication is essential reading for neurobiologists, neurologists, psychopharmacologists, sleep researchers, and other researchers and clinical scientists interested in sleep, sleep research, insomnia, and medicine in general.

Neurochemistry of Sleep and Wakefulness

Author: Jaime Monti

Publisher: Cambridge University Press

Published: 2008-01-17

Total Pages: 506

ISBN-13: 9780521864411

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Pharmacological approaches to our understanding of sleep have been at the forefront of sleep research for many years. Traditional techniques have included the use of pharmacological agonists and antagonists, as well as transmitter-specific lesions. These have been enhanced by the introduction of molecular genetics and the use of transgenes and targeted gene deletion. Neurochemistry of Sleep and Wakefulness is an exceptional, single source of information on the role of the major mammalian neurotransmitter systems involved in the regulation of sleep and waking. With contributions from internationally recognized experts, this book clearly describes how researchers have made use of the myriad techniques in their armamentarium to characterize the role of a given neurotransmitter in the regulation of sleep and waking. Suitable for experimental and clinical pharmacologists, the book will have wider appeal to sleep researchers, psychiatrists and any professional interested in the interdisciplinary areas of neurobiology and pharmacology.

The Mystery of Sleep

Author: Meir Kryger

Publisher: Yale University Press

Published: 2017-03-21

Total Pages: 343

ISBN-13: 0300227825

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An authoritative and accessible guide to what happens when we shut our eyes at night We spend a third of our lives in bed, but how much do we really understand about how sleep affects us? In the past forty years, scientists have discovered that our sleep (or lack of it) can affect nearly every aspect of our waking lives. Poor sleep could be a sign of a disease, the result of a vitamin or iron deficiency, or the cause of numerous other problems, both sleeping and waking. Yet many people, even medical personnel, are unaware of the dangers of poor sleep. Enter Dr. Meir Kryger, a world authority on the science of sleep, with a comprehensive guide to the mysteries of slumber that combines detailed case studies, helpful tables, illustrations, and pragmatic advice. Everyone needs a good night’s sleep, and many of us will experience some difficulty sleeping or staying awake over the course of our lifetimes (or know someone who does). Kryger’s comprehensive text is a much-needed resource for insomniacs; for those who snore, can’t stay awake, or experience disturbing dreams; and for the simply curious. Uniquely wide ranging, The Mystery of Sleep is more than a handbook; it is a guide to the world of sleep and the mysterious disorders that affect it.

Oxford Textbook of Sleep Disorders

Author: Sudhansu Chokroverty

Publisher: Oxford University Press

Published: 2017

Total Pages: 561

ISBN-13: 0199682003

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There has been a rapid global increase in the number of individuals making sleep medicine their career, resulting in an explosive growth in the number of sleep centres and programmes, as well as an increasing number of sleep societies and journals. Part of the Oxford Textbooks in Clinical Neurology series, the Oxford Textbook of Sleep Disorders covers the rapid advances in scientific, technical, clinical, and therapeutic aspects of sleep medicine which have captivated sleep scientists and clinicians. This text aims to introduce sleep disorders within the context of classical neurological diseases, giving an in-depth coverage of the topic in a logical and orderly way, while emphasizing the practical aspects in a succinct and lucid manner. Divided into 12 sections, this book begins by discussing the basic science (Section 1), before moving onto the laboratory evaluation (Section 2) and the clinical science (Section 3). The remainder of the book focuses on specific sleep disorders (Sections 4-12), from insomnias and parasomnias to sleep neurology and sleep and psychiatric disorders. Chapters are supplemented by tables, case reports, and illustrations intended to succinctly provide relevant information in a practical manner for diagnosis and treatment of sleep disorders, while always emphasizing clinical-behavioural-laboratory correlations.