Neurocognitive Rehabilitation of Down Syndrome

Neurocognitive Rehabilitation of Down Syndrome PDF

Author: Jean-Adolphe Rondal

Publisher: Cambridge University Press

Published: 2011-06-02

Total Pages: 253

ISBN-13: 1139497707

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Down syndrome is one of the most commonly occurring developmental disorders and it is now possible to conceptualize and define opportunities for neurocognitive rehabilitation for those with the condition. This book describes how early cognitive intervention in children with Down syndrome can be carried out, and can reduce, or compensate for, the major deficits characteristic of the condition. This comprehensive account relates the neurocognitive approach to the major therapeutic endeavors in the neighboring fields of neurogenetics, experimental environmental enrichment, molecular genetics, pharmacology, pediatrics and cardiology for infants with Down syndrome. Neurocognitive Rehabilitation of Down Syndrome provides the guidance required to establish effective rehabilitation programs, and is essential reading for developmental clinicians, pediatricians, neuropsychologists and other health professionals.

Neurocognitive Rehabilitation of Down Syndrome

Neurocognitive Rehabilitation of Down Syndrome PDF

Author: Jean A. Rondal

Publisher:

Published: 2011

Total Pages:

ISBN-13:

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"Down syndrome is one of the most commonly occurring developmental disorders and it is now possible to conceptualize and define opportunities for neurocognitive rehabilitation for those with the condition. This book describes how early cognitive intervention in children with Down syndrome can be carried out, and can reduce, or compensate for, the major deficits characteristic of the condition. This comprehensive account relates the neurocognitive approach to the major therapeutic endeavors in the neighboring fields of neurogenetics, experimental environmental enrichment, molecular genetics, pharmacology, pediatrics and cardiology for infants with Down syndrome. Neurocognitive Rehabilitation of Down Syndrome provides the guidance required to establish effective rehabilitation programs, and is essential reading for developmental clinicians, pediatricians, neuropsychologists and other health professionals"--Provided by publisher.

Therapies and Rehabilitation in Down Syndrome

Therapies and Rehabilitation in Down Syndrome PDF

Author: Jean-Adolphe Rondal, PhD

Publisher: John Wiley & Sons

Published: 2007-04-04

Total Pages: 228

ISBN-13: 9780470319970

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Therapies and Rehabilitation in Down Syndrome covers the entire lifespan of a DS patient, from infancy to 60 years and beyond, focusing not simply on identifying problems, but providing a detailed look at major therapeutic approaches. Discussion includes future genetic therapy, questions of quality of life, hormone and other therapies for medical problems, prevention and treatment of normal and pathological aging, as well as psychomotoric rehabilitation. This is an important book not only for scientists concerned with various facets of DS, but practitioners looking for guidelines for therapies and clinical application of research findings.

Intellectual Disabilities in Down Syndrome from Birth and throughout Life: Assessment and Treatment

Intellectual Disabilities in Down Syndrome from Birth and throughout Life: Assessment and Treatment PDF

Author: Marie-Claude Potier

Publisher: Frontiers Media SA

Published: 2017-02-24

Total Pages: 183

ISBN-13: 2889450457

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Research on the multiple aspects of cognitive impairment in Down syndrome (DS), from genes to behavior to treatment, has made tremendous progress in the last decade. The study of congenital intellectual disabilities such as DS is challenging since they originate from the earliest stages of development and both the acquisition of cognitive skills and neurodegenerative pathologies are cumulative. Comorbidities such as cardiac malformations, sleep apnea, diabetes and dementia are frequent in the DS population, as well, and their increased risk provides a means of assessing early stages of these pathologies that is relevant to the general population. Notably, persons with DS will develop the histopathology of Alzheimer’s disease (formation of neuritic plaques and tangles) and are at high risk for dementia, something that cannot be predicted in the population at large. Identification of the gene encoding the amyloid precursor protein, its localization to chromosome 21 in the 90’s and realization that all persons with DS develop pathology identified this as an important piece of the amyloid cascade hypothesis in Alzheimer’s disease. Awareness of the potential role of people with DS in understanding progression and treatment as well as identification of genetic risk factors and also protective factors for AD is reawakening. For the first time since DS was recognized, major pharmaceutical companies have entered the search for ameliorative treatments, and phase II clinical trials to improve learning and memory are in progress. Enriched environment, brain stimulation and alternative therapies are being tested while clinical assessment is improving, thus increasing the chances of success for therapeutic interventions. Researchers and clinicians are actively pursuing the possibility of prenatal treatments for many conditions, an area with a huge potential impact for developmental disorders such as DS. Our goal here is to present an overview of recent advances with an emphasis on behavioral and cognitive deficits and how these issues change through life in DS. The relevance of comorbidities to the end phenotypes described and relevance of pharmacological targets and possible treatments will be considerations throughout.

Down Syndrome: From Understanding the Neurobiology to Therapy

Down Syndrome: From Understanding the Neurobiology to Therapy PDF

Author:

Publisher: Elsevier

Published: 2012-10-16

Total Pages: 273

ISBN-13: 0444543007

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Down syndrome (DS) is the most common example of neurogenetic aneuploid disorder leading to mental retardation. In most cases, DS results from an extra copy of chromosome 21 (HSA21) producing deregulated gene expression in brain that gives raise to subnormal intellectual functioning. The topic of this volume is of broad interest for the neuroscience community, because it tackles the concept of neurogenomics, that is, how the genome as a whole contributes to a neurodevelopmental cognitive disorders, such as DS, and thus to the development, structure and function of the nervous system. This volume of Progress in Brain Research discusses comparative genomics, gene expression atlases of the brain, network genetics, engineered mouse models and applications to human and mouse behavioral and cognitive phenotypes. It brings together scientists of diverse backgrounds, by facilitating the integration of research directed at different levels of biological organization, and by highlighting translational research and the application of the existing scientific knowledge to develop improved DS treatments and cures. Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Down Syndrome: From Understanding the Neurobiology to Therapy

Down Syndrome: From Understanding the Neurobiology to Therapy PDF

Author: Mara Dierssen

Publisher: Elsevier

Published: 2012-06-19

Total Pages: 273

ISBN-13: 044454299X

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Down syndrome (DS) is the most common example of neurogenetic aneuploid disorder leading to mental retardation. In most cases, DS results from an extra copy of chromosome 21 (HSA21) producing deregulated gene expression in brain that gives raise to subnormal intellectual functioning. The topic of this volume is of broad interest for the neuroscience community, because it tackles the concept of neurogenomics, that is, how the genome as a whole contributes to a neurodevelopmental cognitive disorders, such as DS, and thus to the development, structure and function of the nervous system. This volume of Progress in Brain Research discusses comparative genomics, gene expression atlases of the brain, network genetics, engineered mouse models and applications to human and mouse behavioral and cognitive phenotypes. It brings together scientists of diverse backgrounds, by facilitating the integration of research directed at different levels of biological organization, and by highlighting translational research and the application of the existing scientific knowledge to develop improved DS treatments and cures. Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Educating Learners with Down Syndrome

Educating Learners with Down Syndrome PDF

Author: Rhonda Faragher

Publisher: Routledge

Published: 2013-10-23

Total Pages: 368

ISBN-13: 1134673426

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For individuals with Down syndrome, the extent of the effect of intellectual disability depends largely on the degree of provision of appropriate support and intervention. In Educating Learners with Down Syndrome, editors Rhonda Faragher and Barbara Clarke have brought together a number of expert contributors, whose chapters review recent findings in the field of DS education, highlight promising practices, and identify areas for future research. While the emphasis is primarily on the school years, links to early intervention and to life post-16 are made, with chapters organized into three parts: conceptual overview of issues in learning and teaching, learning mathematics, and literacy development. The book is also united by the cohesive themes of assessment, evidence-based practice, and inclusive practices. Educating Learners with Down Syndrome importantly incorporates the voices of individuals with Down syndrome, whose personal narratives add significance to the research mission of the text and demonstrate the authors' inclusive philosophy. Aimed at researchers, teacher educators, higher degree students, and policy makers, this book is the first of its kind to provide a compendium of research on educating learners with Down syndrome.

Genetics and Neurobiology of Down Syndrome

Genetics and Neurobiology of Down Syndrome PDF

Author: Bani Bandana Ganguly

Publisher: Academic Press

Published: 2022-08-21

Total Pages: 500

ISBN-13: 0323904572

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Genetics and Neurobiology of Down Syndrome provides a thorough review of the genetic etiology and mechanisms of trisomy 21. The author discusses the history of the syndrome, along with the clinical features and health consequences, including physical features, cognitive, and neurologic symptoms. Genetic counseling on pros and cons of prenatal screening and testing and associated ethical issues are explored. This unique book also covers the societal and demographic aspects as well as the future direction of therapeutic development. Reviews genetic etiology and mechanisms of trisomy 21 Discusses prenatal screening and genetic counseling, including ethical aspects Explores link between Down Syndrome and susceptibility to Alzheimer’s and early brain aging Covers cognitive and neurological symptoms and other health consequences Identifies future therapeutic developments

Handbook of Self-Regulatory Processes in Development

Handbook of Self-Regulatory Processes in Development PDF

Author: Karen Caplovitz Barrett

Publisher: Psychology Press

Published: 2013-05-02

Total Pages: 509

ISBN-13: 1136169121

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The development of self- and emotional regulatory processes helps children to regulate their behavior based on their cultural context and to develop positive social relationships. This handbook brings together heretofore disparate literatures on self- and emotional regulation, brain and physiological processes, mastery motivation, and atypical development to highlight how mastery motivation is related to self-regulation and to clarify the relation between these various processes. Authors from a variety of countries and backgrounds provide an integrated, up-to-date review of the research and the key theoretical models to demonstrate how these processes relate to cultural and individual differences in both typical and atypical development. The renowned editors, all experts in a particular domain of self-regulation, provide section opening chapters that review the literature, provide a perspective that explains the findings, and suggest directions for future research. Although the focus is on quantitative studies, some qualitative findings and research using brain imaging methodologies are included. Outstanding features include: Reviews the development of self and emotional regulation from infancy through adolescence. Contributors from various countries and backgrounds provide an integrative review of the literature to guide the direction of future research. Features contributions from those who have had a strong impact on self-regulation research. Reviews research on developmental disorders that have implications for self-regulation. There are four sections. Section one introduces the development of self- and emotional regulation. This section reviews how self-regulation adapts based on personal and culturally-based goals and how individual differences predispose some to behavior disorders. Socialization influences are examined including a look at when typical regulation processes go awry. Section 2 examines physiological and brain processes as they relate to the development of typical and atypical processes, along with neurocognitive development of performance monitoring and how these processes change over time, cortical activation differences, and behavioral and electrocortical measures of attentional bias. Section 3 reviews the development of self-regulation and mastery motivation including a review of the Dimensions of Mastery Questionnaire (DMQ), cross-national comparisons, and what the DMQ can tell us about self-regulation. The section concludes with a look at the development of self-regulation and mastery motivation in individuals with a developmental disability. Section 4 examines self-regulation in atypical development and evidence-based treatment approaches in children with ADHD, autism, and Down syndrome. This book is intended for researchers, graduate students, and practitioners in psychology, neuroscience, human development, and education interested in the development of self and emotional regulatory processes.