Oxytocin, Vasopressin and Related Peptides in the Regulation of Behavior

Oxytocin, Vasopressin and Related Peptides in the Regulation of Behavior PDF

Author: Elena Choleris

Publisher: Cambridge University Press

Published: 2013-04-11

Total Pages: 409

ISBN-13: 1107328055

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The mammalian neurohypophyseal peptide hormones oxytocin and vasopressin act to mediate human social behavior - they affect trust and social relationships and have an influence on avoidance responses. Describing the evolutionary roots of the effects that these neuropeptides have on behavior, this book examines remarkable parallel findings in both humans and non-human animals. The chapters are structured around three key issues: the molecular and neurohormonal mechanisms of peptides; phylogenetic considerations of their role in vertebrates; and their related effects on human behavior, social cognition and clinical applications involving psychiatric disorders such as autism. A final chapter summarizes current research perspectives and reflects on the outlook for future developments. Providing a comparative overview and featuring contributions from leading researchers, this is a valuable resource for graduate students, researchers and clinicians in this rapidly developing field.

Oxytocin in Brain Health and Disease: How can it exert such pleiotropic neuromodulatory effects?

Oxytocin in Brain Health and Disease: How can it exert such pleiotropic neuromodulatory effects? PDF

Author: Francesca Talpo

Publisher: Frontiers Media SA

Published: 2023-06-08

Total Pages: 145

ISBN-13: 2832525997

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Oxytocin is a pituitary hormone able to produce a multitude of heterogeneous central and peripheral responses. Within the central nervous system, oxytocin is synthesized by the hypothalamic parvocellular neurons and released in many different brain areas where it acts as a neuromodulator. It exerts pro-social and anxiolytic effects by promoting attachment, trust, maternal bonding, social affiliation, and eating and metabolic functions. Imbalances in the oxytocinergic system are implicated in neuropsychiatric diseases associated with altered socio-emotional competence, such as autism spectrum disorder, clinical depression, and eating disorders. Also, oxytocin impairments could affect memory formation/persistence and they have been found in some neurodegenerative diseases, such as Alzheimer's disease, and in several cancers. Although substantial progress has been achieved in understanding single pieces of the complex neurobiology of the oxytocinergic system, the puzzle is far from being complete. It is still unclear how this single neuropeptide could exert such pleiotropic neuromodulatory effects. Extending the comprehension of the mechanisms underlying the complex roles of the oxytocin will be of great interest, as this molecule has the potentiality to be used as a drug treatment.

Behavioral Pharmacology of Neuropeptides: Oxytocin

Behavioral Pharmacology of Neuropeptides: Oxytocin PDF

Author: Rene Hurlemann

Publisher: Springer

Published: 2018-07-09

Total Pages: 593

ISBN-13: 3319637398

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This volume collects cutting-edge expert reviews in the oxytocin field and will be of interest to a broad scientific audience ranging from social neuroscience to clinical psychiatry. The role of the neuropeptide oxytocin in social behaviors is one of the earliest and most significant discoveries in social neuroscience. Influential studies in animal models have delineated many of the neural circuits and genetic components that underlie these behaviors. These discoveries have inspired researchers to investigate the effects of oxytocin on brain and behavior in humans and its potential relevance as a treatment for psychiatric disorders including borderline personality disorder and autism and schizophrenia spectrum disorders. In fact, there is no established social psychopharmacology in Psychiatry, and oxytocin can be seen as the first endogenous agent specifically addressing social-cognitive impairment in psychiatric disorders, with animal research suggesting that it could be especially efficient in the early postnatal period. From a human perspective, it is crucial to understand more precisely who can benefit from potential oxytocin-related treatments, which outcome measures will best represent their effects, how they should be administered, and what brain mechanisms are likely involved in mediating their effects. This type of “precision medicine” approach is in line with the research domain criteria defined by the U.S. National Institute of Mental Health.

Oxytocin in Maternal, Sexual, and Social Behaviors

Oxytocin in Maternal, Sexual, and Social Behaviors PDF

Author: Cort A. Pedersen

Publisher:

Published: 1992

Total Pages: 512

ISBN-13:

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This volume presents the proceedings of a New York Academy of Sciences conference held in May 1991. It focuses on the CNS oxytocin systems in maternal, sexual and social behaviours as both an intitial activator of those behaviours and a determinant of the duration, sequencing and pacing of sexual and mother-infant interactions which are critical for fertilisation and for successful nurturing of offspring.

Handbook of Neurochemistry and Molecular Neurobiology

Handbook of Neurochemistry and Molecular Neurobiology PDF

Author: Ramon Lim

Publisher: Springer Science & Business Media

Published: 2006-09-18

Total Pages: 691

ISBN-13: 0387303480

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"The Handbook is intended to be a service to the neuroscience community, to help in finding available and useful information, to point out gaps in our knowledge, and to encourage continued studies. It represents the valuable contributions of the many authors of the chapters and the guidance of the editors and most important, it represents support for research in this discipline. Based on the rapid advances in the years since the second edition."--Publisher's website.

Vasopressin and Oxytocin: From Genes to Clinical Applications

Vasopressin and Oxytocin: From Genes to Clinical Applications PDF

Author: D. Poulain

Publisher: Elsevier

Published: 2002-10-24

Total Pages: 392

ISBN-13: 0080522823

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The articles comprising this volume were first presented at the World Congress on Neurohypophysial Hormones held in Bordeaux, France on September 8-12, 2001. This conference brought together more than 170 scientists from 18 countries who belong to the different fields of interest representing research in the hypothalamo-neurohypophysial system. Two neurohypophysial neurohormones, oxytocin and vasopressin, exert a variety of central and peripheral actions and thus involve different scientific domains, which too often, even today, do not always find the appropriate occasion to interact. This volume is composed of chapters dealing with topics varying from basic and clinical neurosciences and neuroendocrinology, to reproductive, renal, cardiovascular physiology and pathology. It encompasses all areas of current neurohypophysial research and should be of vital interest as an integrative reference volume to specialized investigators and as an excellent introductory text to students, scientists and clinicians not yet closely familiar with the field. To ensure novelty and to make sure that all topics of current importance were covered, plenary and symposium speakers as well as poster presentations concentrated on recent advances made in the last few years.

Oxytocin and Social Function

Oxytocin and Social Function PDF

Author: Wei Wu

Publisher: BoD – Books on Demand

Published: 2024-01-24

Total Pages: 160

ISBN-13: 1837691177

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Welcome to the world of Oxytocin and Social Function, an in-depth exploration of the powerful role of this neuropeptide in shaping our social behaviors and interactions. The book delves into the rich and complex relationship between oxytocin and our social functions. Featuring contributions from leading experts in the field, this book offers a comprehensive understanding of oxytocin’s role in our social lives. It goes beyond the laboratory to explore the hormone’s potential in real-world applications. The book also highlights recent research on oxytocin’s role in enhancing empathy, reducing stress, and promoting overall well-being. With this book, readers will gain a deeper understanding of the intricate workings of oxytocin and how it shapes our social behaviors and relationships. Oxytocin and Social Function is a must-read for anyone interested in human behavior, psychology, neuroscience, or the ever-growing field of oxytocin research. Turn the page and embark on a captivating journey into the hidden potentials of oxytocin and its transformative effects on our social function.

Vasopressin and Oxytocin

Vasopressin and Oxytocin PDF

Author: Hans H. Zingg

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 464

ISBN-13: 1461548713

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This monograph provides a comprehensive overview of recent advances in the field of vasopressin and oxytocin. In the summer of 1997, scientists from over 20 countries congregated in Montreal for the 1997 World Congress of Neurohypophysial Hormones, a conference that united the fields of vasopressin, neurohypophysis and oxytocin in a single joint meeting that gave rise to the present book. The organization of a joint meeting was prompted by several recent developments. Specifically the molecular characterization of the vasopressin/oxytocin receptor family made it mandatory to adopt an integrated view and to discuss the vasopressin/oxytocin ligand/receptor family as a whole. To ensure em phasis on novelty, the conference focused on advances made over the last two years and also included important contributions by scientists that had not previously been associated with the vasopressin/oxytocin field. Vasopressin and oxytocin are two neurohormones that exert a wide spectrum of cen tral and peripheral actions. Accordingly, the vasopressin/oxytocin field embraces a large number of different domains, ranging from neuroscience, endocrinology, and oncology to renal, reproductive, and cardiovascular physiology and pathology.