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Neural Metabolism In Vivo

Author: In-Young Choi

Publisher: Springer Science & Business Media

Published: 2012-03-14

Total Pages: 1168

ISBN-13: 1461417872

From the preface: “Neural Metabolism In Vivo aims to provide a comprehensive overview of neurobiology by presenting the basic principles of up-to-date and cutting-edge technology, as well as their application in assessing the functional, morphological and metabolic aspects of the brain. Investigation of neural activity of the living brain via neurovascular coupling using multimodal imaging techniques extended our understanding of fundamental neurophysiological mechanisms, regulation of cerebral blood flow in connection to neural activity and the interplay between neurons, astrocytes and blood vessels. Constant delivery of glucose and oxygen for energy metabolism is vital for brain function, and the physiological basis of neural activity can be assessed through measurements of cerebral blood flow and consumption of glucose and oxygen.... This book presents the complex physiological and neurochemical processes of neural metabolism and function in response to various physiological conditions and pharmacological stimulations. Neurochemical detection technologies and quantitative aspects of monitoring cerebral energy substrates and other metabolites in the living brain are described under the “Cerebral metabolism of antioxidants, osmolytes and others in vivo” section. Altogether, the advent of new in vivo tools has transformed neuroscience and neurobiology research, and demands interdisciplinary approaches as each technology could only approximate a very small fraction of the true complexity of the underlying biological processes. However, translational values of the emerging in vivo methods to the application of preclinical to clinical studies cannot be emphasized enough. Thus, it is our hope that advances in our understanding of biochemical, molecular, functional and physiological processes of the brain could eventually help people with neurological problems, which are still dominated by the unknowns.” -- In-Young Choi and Rolf Gruetter

Cerebral Metabolism and Neural Function

Author: Janet V. Passonneau

Publisher:

Published: 1980

Total Pages: 440

ISBN-13:

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Metabolic Reactions in the Nervous System

Author: Abel Lajtha

Publisher: Springer Science & Business Media

Published: 2013-11-21

Total Pages: 600

ISBN-13: 146157160X

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When the projected volumes of the Handbook are completed, most of our current knowledge of the biochemistry of nervous systems will have been touched upon. A number of the chapters will have dealt with the correlations of the biochemical findings with morphological and physio logical parameters as well. Considering the abysmal lack of such attempts, even in the recent past, this is a sign of great progress. If the reader's eventual goal is to derive the "laws" that relate various aspects of animal and human behavior to underlying physiological and biochemical function, these admirable volumes will help him to establish a firm biochemical base from which to operate. It is certain that the future approaches to the various problems of the information-processing functions of the nervous system will require an integrated understanding of the essence of all of the scientific disciplines which are grouped under the general name of neuro biology. The rich feast of information offered up in this Handbook will enable those in the non-chemical disciplines to pick and choose those areas of chemical information pertinent to their immediate interests. Similar types of compendia by physiologists, anatomists, cyberneticists, and psychologists have been helpful to chemists and continue to be so.

Metabolism in the Nervous System

Author: Abel Lajtha

Publisher: Springer Science & Business Media

Published: 2013-03-09

Total Pages: 707

ISBN-13: 1468443674

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This volume is concerned with metabolic reactions occurring in the nervous system. Some time ago, it was thought that since most of the intermediary metabolism that can be observed in the brain is not specific to this organ, there is little justification in studying neural metabolism as such. Later it was realized that for an understanding of neural functions, the understanding of metabolism in the brain and its alterations is essential. All aspects of the metabolism of a substrate in brain, or all metabolic reactions of the nervous system, could not be included in this volume; some will be dealt with in other volumes (such as the ones covering metabolic turn over, alterations of metabolism, or pathology). Review of the aspects covered here clearly shows that the study of metabolic reactions in the nervous system is a very active field, producing important results. As in so many areas of research, as we learn more, new aspects become known, new questions emerge, and we see that in solving some problems we open areas with many additional problems to solve. But the accomplishments to date are impressive and indicate further important advances in the future. Brain metabolism is more active, more plastic, and more comprehensive than previously estimated. It is an essential part of brain function, and with its alteration, brain function will be altered. This shows the importance of more knowledge in this area. It is hoped that this volume will be of assistance in such further studies.

Neural Metabolism In Vivo

Author: In-Young Choi

Publisher: Springer Science & Business Media

Published: 2012-03-08

Total Pages: 1168

ISBN-13: 1461417880

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Brain Energy Metabolism

Author: Johannes Hirrlinger

Publisher: Humana Press

Published: 2014-09-16

Total Pages: 0

ISBN-13: 9781493910588

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Brain Energy Metabolism addresses its challenging subject by presenting diverse technologies allowing for the investigation of brain energy metabolism on different levels of complexity. Model systems are discussed, starting from the reductionist approach like primary cell cultures which allow assessing of the properties and functions of a single brain cell type with many different types of analysis, however, at the expense of neglecting the interaction between cell types in the brain. On the other end, analysis in animals and humans in vivo is discussed, maintaining the full complexity of the tissue and the organism but making high demands on the methods of analysis. Written for the popular Neuromethods series, chapters include the kind of detailed description and key implementation advice that aims to support reproducible results in the lab. Meticulous and authoritative, Brain Energy Metabolism provides an ideal guide for researchers interested in brain energy metabolism with the hope of stimulating more research in this exciting and very important field.

In Vivo Optical Imaging of Brain Function

Author: Ron D. Frostig

Publisher: CRC Press

Published: 2009-05-06

Total Pages: 494

ISBN-13: 142007685X

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These are exciting times for the field of optical imaging of brain function. Rapid developments in theory and technology continue to considerably advance understanding of brain function. Reflecting changes in the field during the past five years, the second edition of In Vivo Optical Imaging of Brain Function describes state-of-the-art techniques a

Metabolomics by In Vivo NMR

Author: Robert G. Shulman

Publisher: John Wiley & Sons

Published: 2005-01-24

Total Pages: 218

ISBN-13:

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This book is unique in linking in vivo 13C NMR measurements of neuronal activity and energetics with applications to functional imaging and certain disease states. Provides a fundamental neurochemical explanation of brain activity applicable to functional imaging, theories of neuronal activity and disease states, e.

Neuron Signaling in Metabolic Regulation

Author: Qingchun Tong

Publisher: CRC Press

Published: 2021-06-07

Total Pages: 330

ISBN-13: 100036691X

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This book focuses on neuron signaling in the regulation of metabolism and body weight, and especially on methods used in these studies. Obesity and related metabolic syndromes have reached epidemic status, but still are no effective strategies for prevention and treatment. Body weight homeostasis is maintained by balanced food intake and energy expenditure, both of which are under the control of brain neurons. In the recent years, significant progress has been made in identifying specific neurons, neural pathways, and non-neuron cells in feeding regulation, as well as in delineating autonomic nervous systems targeting peripheral metabolic tissues in the regulation of energy expenditure and metabolism. This book reviews recent progress on important neuron signaling for body weight and metabolic regulation and the state-of-the-art methods that has been applied in this field, ranging from animal models with neuron-specific manipulations, pharmacology, optogenetics, in vivo Ca2+ imaging, and viral tracing. Readers will be exposed to latest research frontiers on neuron regulation of metabolism. Key Features Explores the role signaling between neurons plays with respect to metabolism Documents how neurotransmitters affect the regulation of feeding Describes various methods and technologies used to study the neuronal control of metabolism Includes contributions from an international team of leading researchers. Related Titles Lim, W. & B. Mayer. Cell Signaling: Principles and Mechanisms (ISBN 978-0-8153-4244-1) Feltz, A. Physiology of Neurons (ISBN 978-0-8153-4600-5) Zempleni, J. & K. Dakshinamurti, eds. Nutrients and Cell Signaling (ISBN 978-0367-39307-6)

Neuroanatomical Tract-Tracing Methods 2

Author: Laszlo Zaborszky

Publisher: Springer Science & Business Media

Published: 2013-03-09

Total Pages: 429

ISBN-13: 1475720556

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This new edition presents readers with the latest information on neuroscience. This book explores the advances in molecular techniques, genomics and proteomics and the progress in fluorescence.