Nanoparticle-Macrophage Interactions

Nanoparticle-Macrophage Interactions PDF

Author: Olesja Bondarenko

Publisher: Mdpi AG

Published: 2022-09-05

Total Pages: 0

ISBN-13: 9783036545998

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Nanoparticles (NPs) offer unique properties for biomedical applications, leading to new nanomedicines. Recent examples of advanced nanoparticle-based nanomedicines are COVID-19 RNA vaccines. Regardless of the delivery route of the NPs into the body (intravenous or subcutaneous injection, oral, intranasal, etc.), NPs inevitably come into contact with immune cells, such as macrophages. Macrophages are phagocytizing cells that determine the fate and the lifetime of NPs in relevant biological fluids or tissues, which has consequences for both nanosafety and nanomedicine. The aim of this Special Issue is to cover recent advancements in our understanding of NP-macrophage interactions, with a focus on in vitro models for nanosafety and novel nanomedicine approaches that allow the modulation of the immunological profile of macrophages. The current Special Issue compiles nine papers: seven research articles and two review articles. The original articles include studies on the interaction of different nanomaterials, such as multi-walled carbon nanotubes (MWCNTs), amorphous silica, gold nanoparticles, lipid carriers, and microspheres, with macrophages in different scenarios.

Polymer Particles

Polymer Particles PDF

Author: Masayoshi Okubo

Publisher: Springer Science & Business Media

Published: 2005-02-10

Total Pages: 388

ISBN-13: 9783540229230

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In this special volume on polymer particles, recent trends and developments in the synthesis of nano- to micron-sized polymer particles by radical polymerization (Emulsion, Miniemulsion, Microemulsion, and Dispersion Polymerizations) of vinyl monomers in environmentally friendly heterogeneous aqueous and supercritical carbon dioxide fluid media are reviewed by prominent worldwide researchers. In addition to the important challenges and possibilities with regards to design and preparation of functionalized polymer particles of controlled size, the topics described are of great current interest due to the increased awareness of environmental issues.

Dendrimers in Biomedical Applications

Dendrimers in Biomedical Applications PDF

Author: Barbara Klajnert

Publisher: Royal Society of Chemistry

Published: 2013

Total Pages: 215

ISBN-13: 1849736111

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This book will provide comprehensive coverage of dendrimer applications and clear indications for future research. It will appeal to chemists, biologists and materials scientists, working in both academia and industry.

Investigating the Performance and Interactions of Conjugated Polymer Nanoparticles with a Macrophage-like Cell Line and Primary Human Blood Cells

Investigating the Performance and Interactions of Conjugated Polymer Nanoparticles with a Macrophage-like Cell Line and Primary Human Blood Cells PDF

Author: Raha Ahmadkhanbeigi

Publisher:

Published: 2015

Total Pages: 318

ISBN-13:

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Introduction. Conjugated polymer nanoparticles (CPN) have attracted wide attention for potential applications in bio-imaging and as theranostics due to their unique properties including strong photoluminescence, excellent photostability and broad absorption spectra. Despite the promising applications of CPNs, there are only a few studies in the literature investigating the biocompatibility profile of these systems. In this project the impact of various CPN compositions (core/shell materials) on particle properties, their behaviour in biological environments and their interactions with human blood cells, was investigated. Methods. Poly[(9,9-di-n-octylfluorenyl-2, 7-diyl)-alt-(benzo[2, 1,3]thiadiazol-4,8-diyl)] (F8BT), poly[2,5-di(3 ', 7 '-dimethyloctyl)phenylene-1,4-ethynylene] (PPE) and poly[2- methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene] (MEH-PPV) CPNs were synthesised using mini-emulsion technique utilising sodium dodecyl sulphate (SDS), a charged stabiliser, PEG(0.6kDa)-12-hydroxystearate (Solutol ®HS 15), a steric stabiliser, or a mix of lipidic 1,2- dipalmitoyl-sn-glycero-3-phosphotidylcholine (DPPC) and PEG(2K)phosphotidylethanolamine, as a stabilising shell. Zeta-potential and hydrophilic-interactionchromatography were used to study nanoparticle surface properties and protein corona formation. The impact of surface properties on nanoparticle internalisation, cytokine release and cytotoxicity was investigated in J77 4A.1 cell line, and the interactions of CPN s with human blood components was studied by investigating the affect of the particles on induction of haemolysis, activation and agglomeration of platelets and platelet-monocyte adhesion.

Microbial Interactions at Nanobiotechnology Interfaces

Microbial Interactions at Nanobiotechnology Interfaces PDF

Author: R. Navanietha Krishnaraj

Publisher: John Wiley & Sons

Published: 2021-11-02

Total Pages: 420

ISBN-13: 1119617197

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MICROBIAL INTERACTIONS AT NANOBIOTECHNOLOGY INTERFACES This book covers a wide range of topics including synthesis of nanomaterials with specific size, shape, and properties, structure-function relationships, tailoring the surface of nanomaterials for improving the properties, interaction of nanomaterials with proteins/microorganism/eukaryotic cells, and applications in different sectors. This book also provides a strong foundation for researchers who are interested to venture into developing functionalized nanomaterials for any biological applications in their research. Practical concepts such as modelling nanomaterials, and simulating the molecular interactions with biomolecules, transcriptomic or genomic approaches, advanced imaging techniques to investigate the functionalization of nanomaterials/interaction of nanomaterials with biomolecules and microorganisms are some of the chapters that offer significant benefits to the researchers.

Characterization of Pharmaceutical Nano- and Microsystems

Characterization of Pharmaceutical Nano- and Microsystems PDF

Author: Leena Peltonen

Publisher: John Wiley & Sons

Published: 2020-12-21

Total Pages: 410

ISBN-13: 1119414040

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Learn about the analytical tools used to characterize particulate drug delivery systems with this comprehensive overview Edited by a leading expert in the field, Characterization of Pharmaceutical Nano- and Microsystems provides a complete description of the analytical techniques used to characterize particulate drug systems on the micro- and nanoscale. The book offers readers a full understanding of the basic physicochemical characteristics, material properties and differences between micro- and nanosystems. It explains how and why greater experience and more reliable measurement techniques are required as particle size shrinks, and the measured phenomena grow weaker. Characterization of Pharmaceutical Nano- and Microsystems deals with a wide variety of topics relevant to chemical and solid-state analysis of drug delivery systems, including drug release, permeation, cell interaction, and safety. It is a complete resource for those interested in the development and manufacture of new medicines, the drug development process, and the translation of those drugs into life-enriching and lifesaving medicines. Characterization of Pharmaceutical Nano- and Microsystems covers all of the following topics: An introduction to the analytical tools applied to determine particle size, morphology, and shape Common chemical approaches to drug system characterization A description of solid-state characterization of drug systems Drug release and permeation studies Toxicity and safety issues The interaction of drug particles with cells Perfect for pharmaceutical chemists and engineers, as well as all other industry professionals and researchers who deal with drug delivery systems on a regular basis, Characterization of Pharmaceutical Nano- and Microsystems also belongs on bookshelves of interested students and faculty who interact with this topic.

Protein-Nanoparticle Interactions

Protein-Nanoparticle Interactions PDF

Author: Masoud Rahman

Publisher: Springer Science & Business Media

Published: 2013-06-24

Total Pages: 95

ISBN-13: 3642375553

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In recent years, the fabrication of nanomaterials and exploration of their properties have attracted the attention of various scientific disciplines such as biology, physics, chemistry, and engineering. Although nanoparticulate systems are of significant interest in various scientific and technological areas, there is little known about the safety of these nanoscale objects. It has now been established that the surfaces of nanoparticles are immediately covered by biomolecules (e.g. proteins, ions, and enzymes) upon their entrance into a biological medium. This interaction with the biological medium modulates the surface of the nanoparticles, conferring a “biological identity” to their surfaces (referred to as a “corona”), which determines the subsequent cellular/tissue responses. The new interface between the nanoparticles and the biological medium/proteins, called “bio-nano interface,” has been very rarely studied in detail to date, though the interest in this topic is rapidly growing. In this book, the importance of the physiochemical characteristics of nanoparticles for the properties of the protein corona is discussed in detail, followed by comprehensive descriptions of the methods for assessing the protein-nanoparticle interactions. The advantages and limitations of available corona evaluation methods (e.g. spectroscopy methods, mass spectrometry, nuclear magnetic resonance, electron microscopy, X-ray crystallography, and differential centrifugal sedimentation) are examined in detail, followed by a discussion of the possibilities for enhancing the current methods and a call for new techniques. Moreover, the advantages and disadvantages of protein-nanoparticle interaction phenomena are explored and discussed, with a focus on the biological impacts.

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