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Myeloproliferative Neoplasms, an Issue of Hematology/Oncology Clinics of North America, Volume 35-2

Author: John Mascarenhas

Publisher: Elsevier

Published: 2021-04-28

Total Pages: 240

ISBN-13: 9780323795883

This issue of Hematology/Oncology Clinics, guest edited by Drs. Ronald Hoffman, Ross Levine, John Mascarenhas, and Raajit Rampal, is dedicated to Myeloproliferative Neoplasms. This issue is one of six selected each year by the series consulting editors, Drs. George P. Canellos and Edward J. Benz. Topics in this issue include-but are not limited to- Overview of pathophysiology and potential drug targets, The role of the megakaryocyte, Epigenetics, Genetics, Novel technologies for understanding MPN biology, Important pathology considerations, Current Clinical investigations, Quality of life, Application of stem cell therapy, Immunotherapy approaches, Clinical unmet needs in ET/PV, Accelerated and blast phase MPNs, Epidemiology, Thrombotic and hemorrhagic complications, Murine modeling, The microenvironment in MPNs, MDS/MPN overlap syndrome, and Advancing effective clinical trial designs.

Myeloproliferative Neoplasms, An Issue of Hematology/Oncology Clinics of North America

Author: John Mascarenhas

Publisher: Elsevier Health Sciences

Published: 2021-02-27

Total Pages: 240

ISBN-13: 0323795897

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This issue of Hematology/Oncology Clinics, guest edited by Drs. Ronald Hoffman, Ross Levine, John Mascarenhas, and Raajit Rampal, is dedicated to Myeloproliferative Neoplasms. This issue is one of six selected each year by the series consulting editors, Drs. George P. Canellos and Edward J. Benz. Topics in this issue include—but are not limited to— Overview of pathophysiology and potential drug targets, The role of the megakaryocyte, Epigenetics, Genetics, Novel technologies for understanding MPN biology, Important pathology considerations, Current Clinical investigations, Quality of life, Application of stem cell therapy, Immunotherapy approaches, Clinical unmet needs in ET/PV, Accelerated and blast phase MPNs, Epidemiology, Thrombotic and hemorrhagic complications, Murine modeling, The microenvironment in MPNs, MDS/MPN overlap syndrome, and Advancing effective clinical trial designs.

Non-CML Myeloproliferative Diseases, An Issue of Hematology/Oncology Clinics of North America - E-Book

Author: Ross Levine

Publisher: Elsevier Health Sciences

Published: 2012-10-14

Total Pages: 240

ISBN-13: 1455747645

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Topics include: Clinical Predictors of Outcome in MPNs; Molecular pathogenesis of MPNs; Disordered signaling in MPNs; Role of TET2/ASXL1 in MPN Pathogenesis; Pathogenesis and treatment of systemic mastocytosis; Role of additional novel therapies in MPNs; Role of novel mutations in MPN pathogenesis and outcome; Role of JAK inhibitors in MPN treatment; Animal Models of MPNs; and Role of Germline Genetic Factors in MPN Pathogenesis.

Consultative Hematology, An Issue of Hematology/Oncology Clinics of North America - E-Book

Author: Fred Schiffman

Publisher: Elsevier Health Sciences

Published: 2012-04-28

Total Pages: 1440

ISBN-13: 1455744077

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Topics include: Why does my patient have leukocytosis?, Why Is My Patient Neutropenic?, Does My Patient with a Serum Monoclonal Spike have Multiple Myeloma?, DVT and Pulmonary Embolism, Why Does My Patient Have Lymphadenopathy/Splenomegaly?,and Why Does My Patient have Thrombocytopenia?

Mathematical Modeling and Computational Predictions in Oncoimmunology

Author: Vladimir A. Kuznetsov

Publisher: Frontiers Media SA

Published: 2024-06-06

Total Pages: 121

ISBN-13: 2832550061

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Cancer is a complex adaptive dynamic system that causes both local and systemic failures in the patient. Cancer is caused by a number of gain-of-function and loss-of-function events, that lead to cells proliferating without control by the host organism over time. In cancer, the immune system modulates cancer cell population heterogeneity and plays a crucial role in disease outcomes. The immune system itself also generates multiple clones of different cell types, with some clones proliferating quickly and maturing into effector cells. By creating regulatory signals and their networks, and generating effector cells and molecules, the immune system recognizes and kills abnormal cells. Anti-cancer immune mechanisms are realized as multi-layer, nonlinear cellular and molecular interactions. A number of factors determine the outcome of immune system-tumor interactions, including cancer-associated antigens, immune cells, and host organisms.

Hematology/Oncology Emergencies, An Issue of Hematology/Oncology Clinics of North America

Author: John C. Perkins

Publisher: Elsevier Health Sciences

Published: 2017-11-06

Total Pages:

ISBN-13: 0323611486

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This issue of Hematology/Oncology Clinics, edited by Drs. John Perkins and and Jonathan Davis, focuses on emergencies related to Hematology/Oncology and covers topics such as: Oncologic Mechanical Emergencies, Neutropenic Fever, Oncologic Metabolic Emergencies, Acute Leukemias, Pediatric Oncologic Emergencies, Chemotherapeutic Medications and their Emergent Complications, Anemia, Thrombotic Microangiopathies (TTP, HUS, HELLP), Congenital Bleeding Disorders, Acquired Bleeding Disorders and Antithrombotic agents, Sickle Cell Disease, and more!

Visual Handbook of Pediatrics and Child Health

Author: Stephen Ludwig

Publisher: Lippincott Williams & Wilkins

Published: 2008

Total Pages: 644

ISBN-13: 9780781795050

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Edited by a well-known expert at the Children's Hospital of Philadelphia, this comprehensive handbook combines a full-color atlas featuring over 1,100 illustrations with a detailed text covering all aspects of child health. The book is organized primarily by body system and covers clinical features, epidemiology, investigations, differential diagnosis, treatment, and prognosis for all disorders seen in children. Illustrations include clinical photographs, imaging, charts, graphs, and histology where appropriate.

Henry's Clinical Diagnosis and Management by Laboratory Methods E-Book

Author: Richard A. McPherson

Publisher: Elsevier Health Sciences

Published: 2021-06-09

Total Pages: 1960

ISBN-13: 0323755089

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For more than 100 years, Henry's Clinical Diagnosis and Management by Laboratory Methods has been recognized as the premier text in clinical laboratory medicine, widely used by both clinical pathologists and laboratory technicians. Leading experts in each testing discipline clearly explain procedures and how they are used both to formulate clinical diagnoses and to plan patient medical care and long-term management. Employing a multidisciplinary approach, it provides cutting-edge coverage of automation, informatics, molecular diagnostics, proteomics, laboratory management, and quality control, emphasizing new testing methodologies throughout. Remains the most comprehensive and authoritative text on every aspect of the clinical laboratory and the scientific foundation and clinical application of today's complete range of laboratory tests. Updates include current hot topics and advances in clinical laboratory practices, including new and extended applications to diagnosis and management. New content covers next generation mass spectroscopy (MS), coagulation testing, next generation sequencing (NGS), transfusion medicine, genetics and cell-free DNA, therapeutic antibodies targeted to tumors, and new regulations such as ICD-10 coding for billing and reimbursement. Emphasizes the clinical interpretation of laboratory data to assist the clinician in patient management. Organizes chapters by organ system for quick access, and highlights information with full-color illustrations, tables, and diagrams. Provides guidance on error detection, correction, and prevention, as well as cost-effective test selection. Includes a chapter on Toxicology and Therapeutic Drug Monitoring that discusses the necessity of testing for therapeutic drugs that are more frequently being abused by users.

How to Talk with Your Doctor

Author: Ronald L. Hoffman, M.D.

Publisher: Turner Publishing Company

Published: 2010-10-15

Total Pages: 407

ISBN-13: 1591205247

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Now more than ever patients are taking control of their own health care, leaving many conventional physicians unsure about their role as dispensers of medical knowledge. More waiting rooms are now filled with highly informed medical consumers seeking to partner with their doctors. They want to explore all promising treatiments, both mainstream and alternative, and connect emotionally. To physicians, these patients seem needy and demanding. They expect a lot of attention, but are all too quick to question authority and battle doctors for control of medical care. To patients, though, such physicans come off as distant and stodgy, even arrogant. Many walk away entirely from mainstream medicine seeking a better partnership or they neglect to mention the alternative tretments they're using for fear of disapproval. Less assertive patients simply clam up-put off by doctors' increasingly brusque bedside manner and shorthand use of "medicalese." The unfortunate result in each case is the same: miscommunication and missed opportunities. Patiens fail to receive the best care available to them, and doctor-patient relationships fall far short of the caring and mutually satisfying exchanges they should be. "How to Talk with Your Doctor" is a book for patients and doctors alike. It arms patients with the tools and knowledge they need to communicate better with physicians about using the best high-tech and alternative treatments while also helping doctors balance their skepticism of complementary and alternative approaches with open-mindedness.

Atlas of Diagnostic Hematology

Author: Mohamed E. Salama

Publisher: Elsevier Health Sciences

Published: 2020-09-01

Total Pages: 415

ISBN-13: 0323567347

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Ideal as a quick, easy-to-use reference in the laboratory or clinical setting, Atlas of Diagnostic Hematology is an abundantly illustrated guide to the vast range of malignant and non-malignant disorders of the blood. More than 1,200 vibrant, full-color images enable you to identify and compare the unique clinical and histologic features of various blood disorders and confidently reach a diagnosis. Coverage includes photos of actual cases that span the entire range of this complex field, including rare conditions and difficult diagnoses. Features more than 1,200 images including full-color pathologic and clinical images covering a wide range of hematologic malignant and non-malignant conditions. Covers a range of disease stages, from the slightest indication where diagnosis can be complicated or missed entirely, to what the average blood or biopsy sample signifying disease may look like, to an advanced stage where disease indications are abundantly clear. Helps you distinguish between similar and overlapping features and symptoms to arrive at an accurate diagnosis. Provides up-to-date information on infectious processes in blood and bone marrow, classification system of myeloid neoplasms, and indolent and aggressive mature T and NK-cell lymphomas. Includes diagnostic algorithms with differential diagnoses for conditions with similar histologic features and clinical symptoms. Contains the latest WHO classifications for pathologic, genetic, and clinical information.