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Myeloproliferative Neoplasms, An Issue of Hematology/Oncology Clinics of North America

Author: John Mascarenhas

Publisher: Elsevier Health Sciences

Published: 2021-02-27

Total Pages: 240

ISBN-13: 0323795897

This issue of Hematology/Oncology Clinics, guest edited by Drs. Ronald Hoffman, Ross Levine, John Mascarenhas, and Raajit Rampal, is dedicated to Myeloproliferative Neoplasms. This issue is one of six selected each year by the series consulting editors, Drs. George P. Canellos and Edward J. Benz. Topics in this issue include—but are not limited to— Overview of pathophysiology and potential drug targets, The role of the megakaryocyte, Epigenetics, Genetics, Novel technologies for understanding MPN biology, Important pathology considerations, Current Clinical investigations, Quality of life, Application of stem cell therapy, Immunotherapy approaches, Clinical unmet needs in ET/PV, Accelerated and blast phase MPNs, Epidemiology, Thrombotic and hemorrhagic complications, Murine modeling, The microenvironment in MPNs, MDS/MPN overlap syndrome, and Advancing effective clinical trial designs.

Myeloproliferative Neoplasms, an Issue of Hematology/Oncology Clinics of North America, Volume 35-2

Author: John Mascarenhas

Publisher: Elsevier

Published: 2021-04-28

Total Pages: 240

ISBN-13: 9780323795883

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This issue of Hematology/Oncology Clinics, guest edited by Drs. Ronald Hoffman, Ross Levine, John Mascarenhas, and Raajit Rampal, is dedicated to Myeloproliferative Neoplasms. This issue is one of six selected each year by the series consulting editors, Drs. George P. Canellos and Edward J. Benz. Topics in this issue include-but are not limited to- Overview of pathophysiology and potential drug targets, The role of the megakaryocyte, Epigenetics, Genetics, Novel technologies for understanding MPN biology, Important pathology considerations, Current Clinical investigations, Quality of life, Application of stem cell therapy, Immunotherapy approaches, Clinical unmet needs in ET/PV, Accelerated and blast phase MPNs, Epidemiology, Thrombotic and hemorrhagic complications, Murine modeling, The microenvironment in MPNs, MDS/MPN overlap syndrome, and Advancing effective clinical trial designs.

Non-CML Myeloproliferative Diseases, An Issue of Hematology/Oncology Clinics of North America - E-Book

Author: Ross Levine

Publisher: Elsevier Health Sciences

Published: 2012-10-14

Total Pages: 240

ISBN-13: 1455747645

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Topics include: Clinical Predictors of Outcome in MPNs; Molecular pathogenesis of MPNs; Disordered signaling in MPNs; Role of TET2/ASXL1 in MPN Pathogenesis; Pathogenesis and treatment of systemic mastocytosis; Role of additional novel therapies in MPNs; Role of novel mutations in MPN pathogenesis and outcome; Role of JAK inhibitors in MPN treatment; Animal Models of MPNs; and Role of Germline Genetic Factors in MPN Pathogenesis.

Consultative Hematology, An Issue of Hematology/Oncology Clinics of North America - E-Book

Author: Fred Schiffman

Publisher: Elsevier Health Sciences

Published: 2012-04-28

Total Pages: 1440

ISBN-13: 1455744077

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Topics include: Why does my patient have leukocytosis?, Why Is My Patient Neutropenic?, Does My Patient with a Serum Monoclonal Spike have Multiple Myeloma?, DVT and Pulmonary Embolism, Why Does My Patient Have Lymphadenopathy/Splenomegaly?,and Why Does My Patient have Thrombocytopenia?

The Treatment of Myeloid Malignancies with Kinase Inhibitors, An Issue of Hematology/Oncology Clinics of North America, E-Book

Author: Ann Mullally

Publisher: Elsevier Health Sciences

Published: 2017-07-14

Total Pages:

ISBN-13: 0323532365

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This issue of Hematology/Oncology Clinics will focus on The Treatment of Myeloid Malignancies with Kinase Inhibitors. Articles will focus on: Targeting aberrant signaling in myeloid malignancies: promise versus reality; The development and use of imatinib for the treatment of chronic myelogenous leukemia; Mechanisms of resistance to ABL kinase inhibition in CML and the development of next generation ABL kinase inhibitors; Tyrosine kinase inhibitors in the treatment of systemic mastocytosis and hypereosinophilic syndrome; The development and use of JAK2 inhibitors for the treatment of myeloproliferative neoplasms (MPN); Mechanisms of resistance to JAK2 inhibitors in MPN; Kinase inhibitor screening in myeloid malignancies; and more!

Myelodysplastic Syndromes An Issue of Hematology/Oncology Clinics of North America

Author: David Steensma

Publisher: Elsevier Health Sciences

Published: 2020-02-26

Total Pages: 193

ISBN-13: 0323722644

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This issue of Hematology/Oncology Clinics, guest edited by David P. Steensma, will cover key topics in Myelodysplastic Syndromes. This issue is one of six selected each year by our series consulting editors, George P. Canellos and Edward J. Benz. Topics discussed in this issue will include: Novel prognostic models for MDS, Evaluating MDS patients with genetic mutations that might be germline, Implications of splicing mutations in MDS for pathophysiology and therapy, Assessing quality of life in MDS/MPN overlap patients, Creation of a clinic for patients with clonal hematopoiesis, Luspatercept in MDS, Prospects for venetoclax in MDS, Treatment of acquired sideroblastic anemias, Treatment of patients with AML arising from MDS, Targeting TP53 mutations in MDS, among others.

Pediatric Hematology, An Issue of Hematology/Oncology Clinics of North America

Author: Rachael Grace

Publisher: Elsevier Health Sciences

Published: 2019-05-05

Total Pages:

ISBN-13: 0323673341

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This issue of Hematology/Oncology Clinics, Guest Edited by Drs. Rachael Grace and Russell E. Ware, will focus on Pediatric Hematology. This issue is one of six selected for the year by the series Consulting Editors, George P. Canellos and H. Franklin Bunn. Topics include, but are not limited to, Rare Congenital Hemolytic Anemias, Sickle Cell, Thalassemia, Neutropenia and rare leukocyte disorders in children, Primary and Secondary Immune cytopenias, Disorders of Iron overload, Disorders of Iron metabolism, Approach to Hemophilia in a Changing Treatment Landscape, Von Willebrand disease, Inherited platelet disorders, Thrombosis, Diagnostic evaluation and medical approach to complications and treatment of vascular anomalies, New approaches and trials in Transfusion Medicine, and Updates in Neonatal Hematology.

Blastic Plasmacytoid Dendritic Cell Neoplasm An Issue of Hematology/Oncology Clinics of North America

Author: Andrew A. Lane

Publisher: Elsevier Health Sciences

Published: 2020-06-02

Total Pages: 161

ISBN-13: 0323722652

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This issue of Hematology/Oncology Clinics, guest edited by Andrew A. Lane, will cover Blastic Plasmacytoid Dendritic Cell Neoplasm. This issue is one of six selected each year by our series consulting editors, Dr. George P. Canellos and Dr. Edward J. Benz. Topics discussed in this issue include: Clinical Presentation and Pathology, Molecular Features of Blastic Plasmacytoid Dendritic Cell Neoplasm: DNA mutations and epigenetics, Cytogenetics of Blastic Plasmacytoid Dendritic Cell Neoplasm, Blastic Plasmacytoid Dendritic Cell Neoplasm Chemotherapy, CD123 and Leukemia Stem Cells, Tagraxofusp for Blastic Plasmacytoid Dendritic Cell Neoplasm, Immune Therapies Targeting CD123 in Blastic Plasmacytoid Dendritic Cell Neoplasm, Novel Therapies for Blastic Plasmacytoid Dendritic Cell Neoplasm, Blastic Plasmacytoid Dendritic Cell Neoplasm in Children, European Perspective, Stem Cell Transplantation for Blastic Plasmacytoid Dendritic Cell Neoplasm, and Social Media in Blastic Plasmacytoid Dendritic Cell Neoplasm and Other Rare Diseases.

Waldenström Macroglobulinemia, An Issue of Hematology/Oncology Clinics of North America E-Book

Author: Jorge J Castillo

Publisher: Elsevier Health Sciences

Published: 2018-09-07

Total Pages:

ISBN-13: 0323641288

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This issue of Hematology/Oncology Clinics, edited by Drs. Jorge J. Castillo, Efstathios Kastritis, and Steven P. Treon, will focus on Waldenström Macroglobulinemia. Topics include, but are not limited to, Genomics; Epigenomics; Flow cytometry; Marrow microenvironment; Familial Waldenstrom; MYD88 L265P and other MYD88 mutations; CXCR4 and other recurrent mutations; Diagnosis and differential diagnosis; Criteria to treat and treatment goals; Alkylators; Monoclonal antibodies; Proteasome inhibitors; BTK inhibitors; Transplant; and Novel approaches.

Bone Marrow Transplantation, An Issue of Hematology/Oncology Clinics of North America,

Author: Bipin Savani

Publisher: Elsevier Health Sciences

Published: 2016-03-25

Total Pages: 308

ISBN-13: 0323354599

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This issue of Hematology/Oncology Clinics of North America, guest edited by Drs. Bipin Savani and Mohamad Mohty, is devoted to Bone Marrow Transplantation. Articles in this issue include: Acute Myeloid Leukemia (AML); Acute Lymphoid Leukemia (ALL); Myelodysplastic Syndrome (AML); Myeloproliferative disorders (MPD); Chronic Lymphoid Leukemia; Chronic Myeloid Leukemia (CML); Multiple Myeloma and Amyloidosis; Non-Hodgkin Lymphoma (NHL); Hodgkin Lymphoma (HL); Severe Aplastic Anemia (SAA) and Paroxysmal Nocturnal Hemoglobinuria (PNH); Sickle Cell Anemia; Thalassemia; Benign immunodeficiency diseases; and Referral to transplant centers.