Surgery in the Multimodal Management of Gastric Cancer

Surgery in the Multimodal Management of Gastric Cancer PDF

Author: Giovanni De Manzoni

Publisher: Springer Science & Business Media

Published: 2012-02-04

Total Pages: 265

ISBN-13: 8847023181

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Although there has been a slow but steady decrease in incidence, gastric cancer remains the second leading cause of cancer death worldwide. Several aspects of the oncological and surgical management are still controversial and so gastric cancer represents a challenge for the surgeon. This book aims to delineate the state of the art in the surgical and oncological treatment of gastric cancer, describing the new TNM staging system, the extent of visceral resection and lymphadenectomy focusing on the different open and minimally invasive surgical techniques and discussing intraoperative chemohyperthermia and neoadjuvant and adjuvant treatment. Operative endoscopy and endoscopic ultrasonography are also discussed, as these now have an important role in both diagnostic work-up and palliative care of gastric cancer patients. Only a multidisciplinary approach involving the surgeon, gastroenterologist, and oncologist can produce the comprehensive and integrated overview that today constitutes a winning strategy for the optimization of results.What we hope we have achieved is a flexible, up-to-date, exhaustive publication, rich in illustrations and consistent with evidence-based medicine.

Gastric Cancer In The Precision Medicine Era

Gastric Cancer In The Precision Medicine Era PDF

Author: Vincenzo Canzonieri

Publisher: Springer

Published: 2019-05-02

Total Pages: 256

ISBN-13: 3030048616

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Gastric cancer is one of the most common and potentially lethal gastrointestinal malignancy, but it is now at the forefront of modern oncology due to new discoveries. In recent years, the field of gastric cancer has been transformed by many notable developments in both the diagnostic area and the therapeutic strategies. The main aim of the text is to propose a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for oncologists, pathologists, surgeons and researchers with an interest in gastric cancer. The first chapters will review the interplay between pathogens and especially H. pylori, inflammation, genomic instability, and tumorigenesis. Secondly, an exhaustive overview of the diagnosis of gastric cancer from a clinical/endoscopic and pathologic perspectives will be illustrated. Two specific chapters will deal with tissue and serum biomarkers with an important role in diagnosis as well as prognostic and predictive markers of response to specific therapy. A central section of the book will focus on treatment options available today for patients. Surgery is the cornerstone of treatment for gastric cancer; however, the prognosis of patients with locally advanced disease is still poor even after curative resection. Therefore, in order to improve the prognosis of patients, especially with advanced stage, a multimodal strategy is advisable and is thoroughly addressed in the appropriate section. With the advent of next-generation sequencing and new preclinical model technologies, the genomic landscape of gastric cancer has been delineated and molecular characterizations finalized to novel therapeutic targets of each molecular subtype have been identified. These advances are making it feasible to integrate clinical and phenotype-based diagnostic and therapeutic methods and are described in a dedicated section. The text will conclude with chapters focusing on the future direction of gastric cancer research in the precision medicine era: an in-depth analysis of non-coding RNAs and their role in gastric cancer, the impact of immunomodulation/immunotherapy and the perspectives of nano-medicine will be finally proposed to the audience. A brief review of the existing literature addressing the above mentioned topics will be present in each chapter. This text will serve as a useful resource for physicians and researchers dealing with, and interested in, this challenging malignancy. It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters will be written by experts in their fields and will include the most up to date scientific and clinical information.

Combined Modality Therapy of Gastrointestinal Tract Cancer

Combined Modality Therapy of Gastrointestinal Tract Cancer PDF

Author: Peter Schlag

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 345

ISBN-13: 3642832938

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Modern surgical oncology is characterized by multimodal therapy. In recent years numerous therapeutic approaches of pre-, peri-, intra-and postoperative treatment have been in vestigated with regard to their use in combination with surgi cal intervention. It now is time to analyze and to define the state of our knowledge. For tumors of the gastrointestinal tract there are several encouraging therapeutic approaches, such as preop erative chemotherapy in esophageal and perioperative chemotherapy in colon cancer. For some special tumors, like anal carcinoma, we have clearly defined combined therapies which even now must be viewed as standard treatment. It is also time to demonstrate the results of several clini cal studies that have been conducted within the last few years that combined surgical efforts with pre- or postinter ventional chemotherapy or radiotherapy. It is necessary to evaluate whether these trials contribute to progress in onco logical therapy. The editors of this volume - surgeons at the university hospitals of Heidelberg and Zurich - must be given the mer it of achieving these goals. It was especially appropriate for the Department of Surgery in Heidelberg, in close coopera tion with the Comprehensive Cancer Center Heidelberg/ Mannheim, to prepare a review of our present knowledge of surgical oncology as it is in the tradition of attempting to combine different therapeutic approaches to cancer therapy.

Management of Gastric Cancer

Management of Gastric Cancer PDF

Author: Paul H. Sugarbaker

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 405

ISBN-13: 1461538823

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Gastric cancer has been one of the great malignant scourges affecting man kind for as long as medical records have been kept. Until operative resection pioneered by Bilroth and others became available, no effective treatment was feasible and death from cancer was virtually inevitable. Even with resection by total gastrectomy, the chances of tumor eradication remained small. Over recent years, however, the situation has been changing. Some changes have resulted from better understanding of the disease, early detec tion, and better management techniques with applied clinical research, but the reasons for other changes are poorly understood. For example, the incidence of gastric cancer is decreasing, especially in westernized societies, where it has fallen from one of the most common cancers to no longer being in the top five causes of cancer death. Still it remains the number one killer of adult males in Japan and Korea. Whether the reduced incidence in western societies is a result of dietary changes or methods of food preservation, or some other reason, is as yet uncertain. Improvements in outcome have been reported from mass screening and early detection; more refined techniques of establishing early diagnosis, tumor type, and tumor extent; more radical surgical resection; and resection at earlier stages of disease.

Pain Management for Advanced Practice

Pain Management for Advanced Practice PDF

Author: Angela Starkweather

Publisher: Lippincott Williams & Wilkins

Published: 2019-09-09

Total Pages: 11201

ISBN-13: 197510336X

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Handle the vital issue of pain management safely and effectively, with the proven range of treatments offered in Pain Management for Advanced Practice. Offering compassionate, holistic pain management strategies — pharmacological and nonpharmacological — this expert guide supports evidence-based decision making, with multimodal care options that include cognitive behavioral therapy, yoga, acupuncture, analgesics and supplementary pharmaceuticals. Essential for clinicians in all practice areas, this is the real-world support all advanced practice clinicians need for managing patients in pain.

Multidisciplinary Management of Gastric Neoplasms, An Issue of Surgical Clinics, E-Book

Multidisciplinary Management of Gastric Neoplasms, An Issue of Surgical Clinics, E-Book PDF

Author: Kelly L. Olino

Publisher: Elsevier Health Sciences

Published: 2017-03-22

Total Pages:

ISBN-13: 0323524346

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This issue of Surgical Clinics of North America focuses on Gastric Neoplasms, and is edited by Drs. Douglas Tyler and Kelly Olino. Articles will include: Minimally Invasive Surgical Approaches to Gastric Resection; The Management of GE Junction Tumors; Post-gastrectomy Syndromes and Nutritional Considerations Following Gastric Surgery; Surgical Considerations in the Management of Gastric Adenocarcinoma; The Evaluation and Management of Suspicious Gastric lesions following Bariatric Surgery; Post-surgical Surveillance for Gastric Adenocarcinoma; Neuroendocrine Tumors of the Stomach; Genetics of Gastric Cancer; The Management of Gastrointestinal Stromal Tumors; Endoscopic Management of Early Gastric Adenocarcinoma and Pre-invasive Gastric Lesions; The Management of Non-Neoplastic Gastric Lesions; East Versus the West: Differences in Surgical Management in Asia Compared to Europe and North America; The Multimodality Approach to Gastric Lymphoma; The Role of Chemotherapy and Radiation Therapy in the Management of Gastric Adenocarcinoma; and more!

Surgery in Multimodal Management of Solid Tumors

Surgery in Multimodal Management of Solid Tumors PDF

Author: Antonio Bolognese

Publisher: Springer Science & Business Media

Published: 2009-03-27

Total Pages: 153

ISBN-13: 8847010853

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Surgery continues to be the most effective treatment of solid tumors in terms of recovery, while its combination with other treatments improves the survival curves especially in the advanced forms of the disease. The aim of my task first of all has been to provide readers with both the current and constantly evolving pathophysiologic knowledge required for building the foundation of a specific education enabling surgeons to meet the fundamental targets in surgical oncology. Secondly, this volume aims to present an update on the real possibilities offered by the cooperation between surgeon and pathologist and by chemotherapy, radiotherapy and gene therapy in the treatment of tumors in the light of the most recent scientific achievements. Lastly, the report presents the experiences and cases drawn mostly from our School regarding some of the major issues in oncologic surgery. This overview does not pretend to elucidate or to summarize all aspects of oncologic surgery, but rather to be the result of a general consideration on cancer surgery, on its rational bases, on its interaction with other treatment modalities, on its desirable and expected developments and on its probable future evolution.

Gastric Cancer: the 25-year R-Evolution

Gastric Cancer: the 25-year R-Evolution PDF

Author: Giovanni de Manzoni

Publisher: Springer Nature

Published: 2021-10-15

Total Pages: 276

ISBN-13: 3030731588

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Twenty-five years ago, a monograph on gastric cancer was published by the Italian Society of Surgery: that book is recognized as a milestone in the management of these tumors in Italy. Oncological and surgical knowledge in the field of gastric cancer have changed dramatically over the last 25 years. The aim of this book is to offer an essential update on current diagnostic approaches and optimal treatment strategies. It gives comprehensive information on gastric cancer not neglecting the basic sciences, which can shed light on the carcinogenesis mechanisms involved in this pathology. The principles of tailored and multimodal treatment are examined according to the latest guidelines with the aim of providing a valuable synopsis for clinicians. The book not only reviews what has changed in the field of gastric cancer over the past quarter century but also offers the reader a glimpse of the future by describing the ongoing surgical and oncological trials which focus on new treatment frontiers such as immunotherapy and target therapy. It also seeks to incorporate the latest discoveries based on molecular classifications. Further, the book reflects the findings and experiences of Italian experts belonging to the GIRCG (Italian Research Group for Gastric Cancer) and will offer an excellent guide for oncological surgeons in their daily practice of caring for patients affected by gastric cancer.