Multi-Omics Analysis in Tumor Microenvironment and Tumor Heterogeneity
Author: Jinhui Liu
Publisher: Frontiers Media SA
Published: 2023-09-25
Total Pages: 517
ISBN-13: 2832534287
DOWNLOAD EBOOK →Lanterna Rally
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Multi-Omics Approaches for Decoding Heterogeneity in Cancer Immunotherapy
Author: Lin Qi
Publisher: Frontiers Media SA
Published: 2023-11-22
Total Pages: 267
ISBN-13: 2832539653
DOWNLOAD EBOOK →Multi-omic Data Integration in Oncology
Author: Chiara Romualdi
Publisher: Frontiers Media SA
Published: 2020-12-03
Total Pages: 187
ISBN-13: 2889661512
DOWNLOAD EBOOK →This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Preclinical Models and Emerging Technologies to Study the Effects of the Tumor Microenvironment on Cancer Heterogeneity and Drug Resistance
Author: Giulia Adriani
Publisher: Frontiers Media SA
Published: 2023-10-26
Total Pages: 171
ISBN-13: 2832537030
DOWNLOAD EBOOK →Metastatic Progression and Tumour Heterogeneity
Author: Fred Hollande
Publisher: MDPI
Published: 2021-01-21
Total Pages: 314
ISBN-13: 3039288539
DOWNLOAD EBOOK →Improved understanding of the cellular and molecular makeup of tumors in the last 30 years has unraveled a previously unexpected level of heterogeneity among tumor cells as well as within the tumor microenvironment. The concept of tumor heterogeneity underlines the realization that different tumors can display significant differences in their genomic content as well as in their overall behavior. Our capacity to better understand the heterogeneous make up of tumors has very important consequences on our ability to design efficient therapeutic strategies to improve patient survival. This book highlights several aspects of tumor heterogeneity in the context of metastatic development and summarize some of the challenges posed by heterogeneity for tumor diagnostics and therapeutic management of tumors.
Ex Vivo Engineering of the Tumor Microenvironment
Author: Amir R. Aref
Publisher: Springer
Published: 2016-12-09
Total Pages: 142
ISBN-13: 3319453971
DOWNLOAD EBOOK →This volume will outline how to recreate the tumor microenvironment, to culture primary tumors without the need for developmental priming factors, and to deliver targeted therapeutics in a manner that recapitulates pharmacokinetics in vivo. Much of what may be learned from this volume will aid in understanding many aspects of the enhanced study of tumor cell biology in a physiologic context, open new avenues for drug screening and biomarker development, and accelerate the preclinical evaluation of novel personalized medicine strategies for patients in real time.
Integrative Multi-omics Analysis to Understand Cancer and Anticancer Therapy
Author: Michelle Ting Dow
Publisher:
Published: 2020
Total Pages: 197
ISBN-13:
DOWNLOAD EBOOK →Precision cancer medicine promises better treatments to a disease as complex and heterogenous as cancer. Many anti-cancer therapies are beneficial to only a subset of patients due to the variability in patient genetic and tumor heterogeneity. Thus, we need better frameworks for understanding underlying genomic and transcriptomic patterns influencing differential patient outcomes, yet our understanding of how genetic alterations connect to treatment in in vivo and in vitro models remains understudied. To address this gap, I utilized human patient data from The Cancer Genome Atlas (TCGA), hepatocellular carcinoma (HCC) models, prostate cancer (PCa) models, and chronic myelogenous leukemia (CML) cell lines. Through the integration of multi-omic data, I identified parallel features of human and model organism data that could reveal disease specific characteristics. Additionally, I characterized the landscape of acquired resistance for a panel of chemotherapeutic treatments and revealed potential alleles and genes that mediate the process. The analyses I conducted expose the role of genetic information and suggest future applications for development of precision medicine.
Cancer Evolution
Author: Charles Swanton
Publisher: Perspectives Cshl
Published: 2017
Total Pages: 350
ISBN-13: 9781621821434
DOWNLOAD EBOOK →Tumor progression is driven by mutations that confer growth advantages to different subpopulations of cancer cells. As a tumor grows, these subpopulations expand, accumulate new mutations, and are subjected to selective pressures from the environment, including anticancer interventions. This process, termed clonal evolution, can lead to the emergence of therapy-resistant tumors and poses a major challenge for cancer eradication efforts. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines cancer progression as an evolutionary process and explores how this way of looking at cancer may lead to more effective strategies for managing and treating it. The contributors review efforts to characterize the subclonal architecture and dynamics of tumors, understand the roles of chromosomal instability, driver mutations, and mutation order, and determine how cancer cells respond to selective pressures imposed by anticancer agents, immune cells, and other components of the tumor microenvironment. They compare cancer evolution to organismal evolution and describe how ecological theories and mathematical models are being used to understand the complex dynamics between a tumor and its microenvironment during cancer progression. The authors also discuss improved methods to monitor tumor evolution (e.g., liquid biopsies) and the development of more effective strategies for managing and treating cancers (e.g., immunotherapies). This volume will therefore serve as a vital reference for all cancer biologists as well as anyone seeking to improve clinical outcomes for patients with cancer.
Tumor Heterogeneity: Diagnostics and Therapeutic Management of Tumors
Author: Joanna Murray
Publisher: Foster Academics
Published: 2023-09-26
Total Pages: 0
ISBN-13: 9781646465569
DOWNLOAD EBOOK →Tumor cells have a remarkable ability to survive in harsh circumstances, resist treatment and evade regulatory mechanisms like apoptosis and therapy. They alter their metabolism in order to sustain metastatic progression and uncontrolled growth. Functional and phenotypic heterogeneity in tumor cells gives them metastatic potential, aggressiveness and the capability to resist treatment. This heterogeneity is governed by a range of intrinsic and extrinsic stimuli involving the ones from the tumor microenvironment. Various tumor cells can exhibit heterogeneous phenotypic and morphological profiles comprising gene expression, metastatic potential, metabolism, proliferation, cellular morphology and motility. It have been detected in many types of cancer including breast cancer, head and neck cancer, gynecological carcinoma, multiple myeloma, leukemia, prostate cancer, colon cancer, bladder, brain cancer and liposarcoma. This book contains some path-breaking studies on tumor heterogeneity. It strives to provide a fair idea about tumor heterogeneity and to help develop a better understanding of the diagnostics and therapeutic management of tumors. This book will help new researchers by foregrounding their knowledge in this area of study.
Epithelial-Mesenchymal Plasticity in Cancer Metastasis
Author: Mohit Kumar Jolly
Publisher: MDPI
Published: 2020-12-29
Total Pages: 512
ISBN-13: 3039367242
DOWNLOAD EBOOK →Recent studies have highlighted that epithelial-mesenchymal transition (EMT) is not only about cell migration and invasion, but it can also govern many other important elements such as immunosuppression, metabolic reprogramming, senescence-associated secretory phenotype (SASP), stem cell properties, therapy resistance, and tumor microenvironment interactions. With the on-going debate about the requirement of EMT for cancer metastasis, an emerging focus on intermediate states of EMT and its reverse process mesenchymal-epithelial transition (MET) offer new ideas for metastatic requirements and the dynamics of EMT/MET during the entire metastatic cascade. Therefore, we would like to initiate discussions on viewing EMT and its downstream signaling networks as a fulcrum of cellular plasticity, and a facilitator of the adaptive responses of cancer cells to distant organ microenvironments and various therapeutic assaults. We hereby invite scientists who have prominently contributed to this field, and whose valuable insights have led to the appreciation of epithelial-mesenchymal plasticity as a more comprehensive mediator of the adaptive response of cancer cells, with huge implications in metastasis, drug resistance, tumor relapse, and patient survival.
