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mRNA Metabolism & Post-Transcriptional Gene Regulation

Author: Joe B. Harford

Publisher: John Wiley & Sons

Published: 1997-03-28

Total Pages: 372

ISBN-13: 9780471142065

mRNA METABOLISM & POST-TRANSCRIPTIONAL GENE REGULATION Edited by Joe B. Harford and David R. Morris Gene expression is a process that begins with the transcription ofDNA to an RNA messenger (mRNA), which is then translated into aprotein. Historically, attention has been focused on the regulationof RNA synthesis (transcription); however, there is a growingrecognition of and appreciation for the importance of the manyregulatory mechanisms that take place after RNA synthesis has beencompleted. mRNA Metabolism and Post-Transcriptional Gene Regulation is thefirst comprehensive overview of the various modes of generegulation that exist post-transcriptionally. Collecting studies bysome of the top researchers in the field, this volume provides bothan up-to-date review of the complex "life" of an mRNA molecule andan introduction to current work on the diversity of mechanisms ofpost-transcriptional reactions. Topics covered include: * RNA structure * Mammalian RNA editing * RNA export from the nucleus * The fundamentals of translation initiation * Control of mRNA decay in plants * mRNA metabolism and cancer * Control of mRNA stability during herpes simplex virus infection * Regulation of mRNA expression in HIV-1 and other complexretroviruses * Nucleases * RNA localization A timely contribution to the understanding of genetic regulatorymechanisms, mRNA Metabolism and Post-Transcriptional GeneRegulation provides a basis from which potential therapeuticstrategies may be developed. This book will be of vital interest tocell and molecular biologists at all levels, from graduate studentsto senior investigators, clinical researchers, and professionals inthe pharmaceutical and biotechnology industries.

Post-Transcriptional Gene Regulation

Author: Jeffrey Wilusz

Publisher: Springer Science & Business Media

Published: 2008

Total Pages: 330

ISBN-13: 1588297837

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The mRNA Metabolism in Human Disease

Author: Luísa Romão

Publisher: Springer

Published: 2019-07-24

Total Pages: 180

ISBN-13: 3030199665

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The eukaryotic gene expression pathway involves a number of interlinked steps, with messenger RNA (mRNA) being the key intermediate. The precursor mRNA is transcribed from DNA, processed by removal of introns and addition of the cap structure and the poly(A) tail. The mature mRNA is then exported to the cytoplasm where it is translated into protein and finally degraded. In this process, mRNA is associated with RNA-binding proteins forming ribonucleoprotein complexes, whose protein content evolves throughout the lifetime of the mRNA. While the complexity of eukaryotic gene expression allows the production of proteins to be controlled at many levels, it also makes the process vulnerable to errors. Although eukaryotic cells have evolved elaborate mRNA quality control mechanisms that ensure the fidelity of gene expression, some defects are not detected, thus affecting mRNA metabolism. This condition plays a fundamental role in the pathogenesis of several disease processes, such as neurodegeneration and oncogenesis. Besides, exciting recent data have shown that cellular RNAs can be modified post-transcriptionally via dynamic and reversible chemical modifications, the so-called epitranscriptome. These modifications can alter mRNA structure, being able to modulate different steps of the mRNA metabolism that can be associated with various human diseases, such as systemic lupus erythematosus and cancer. This book provides a collection of novel studies and hypotheses aimed to define the pathophysiological consequences of altered mRNA metabolism events in human cells, and is written for a wide spectrum of readers in the field of gene expression regulation. The last chapter highlights how the discovery of disease-causing defects (or modifications) in mRNA can provide a variety of therapeutic targets that can be used for the development of new RNA-based therapeutics. Hopefully, it may also contribute to inspire the drug-developing scientific community.

A Time for Metabolism and Hormones

Author: Paolo Sassone-Corsi

Publisher: Springer

Published: 2016-04-04

Total Pages: 132

ISBN-13: 3319270699

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Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field. The editors trust that this volume will be of use to those colleagues who will be picking up the challenge to unravel how the circadian clock can be targeted for the future development of specific pharmacological strategies toward a number of pathologies.

Post-transcriptional Gene Regulation in Human Disease

Author: Buddhi Prakash Jain

Publisher: Academic Press

Published: 2022-08-12

Total Pages: 396

ISBN-13: 0323914241

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Post-transcriptional Gene Regulation in Human Disease, a new volume in the Translational Epigenetics book series, offers a thorough overview and discussion of post-transcriptional genetic control mechanisms and their roles across various pathologies and human developmental outcomes, along with regulatory mechanisms targeted for therapeutic approaches. The book is broadly divided in two parts: early chapters describe the basics of post-transcriptional gene regulation, associated epigenetic mechanisms, the role of RNA binding proteins, the evolution of post-transcriptional gene regulation, and methods to study these mechanisms. The second half of the book includes deeper discussion of post-transcriptional gene regulation across specific diseases and therapeutics targets. Various post-transcriptional events, including alternative splicing and polyadenylation, mRNA stability, and miRNAs and their involvement in the disease progression, are examined in detail. Includes full-color imagery illustrating key concepts and post-transcriptional disease processes, as well as descriptions of methods for studying post-transcriptional gene regulation Presents fundamental knowledge, molecular and biochemical mechanisms, and recent findings in concise and easily understandable formats Features a summary and conclusion at the end of each chapter

Post‐Transcriptional Regulation by STAR Proteins

Author: Talila Volk

Publisher: Springer Science & Business Media

Published: 2011-01-11

Total Pages: 176

ISBN-13: 1441970053

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This book examines the available information on the structure of the RNA binding STAR domain and provides insights into how these proteins discriminate between different RNA targets. It reviews what is known about STAR proteins and human disease.

RNA Binding Proteins

Author: Kathryn Sandberg

Publisher: Springer Science & Business Media

Published: 2013-03-09

Total Pages: 318

ISBN-13: 1475764464

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RNA binding proteins are an exciting area of research in gene regulation. A multitude of RNA-protein interactions are used to regulate gene expression including pre-mRNA splicing, polyadenylation, editing, transport, cytoplasmic targeting, translation and mRNA turnover. In addition to these post-transcriptional processes, RNA-protein interactions play a key role in transcription as illustrated by the life cycle of retroviruses. Unlike DNA, the structure of RNA is highly variable and conformationally flexible, thus creating a number of unique binding sites and the potential for complex regulation by RNA binding proteins. Although there is a wide range of topics included in this volume, general themes have been repeated, highlighting the overall integrative nature of RNA binding proteins. The chapters have been separated into three different sections: Translational Control; mRNA Metabolism; and Hormonal and Homeostatic Regulation. The chapters of this volume were written with the seasoned investigator and student in mind. Summaries of key concepts are reviewed within each chapter as well as guiding questions that can be used to stimulate class discussions. The Editors of this volume hope that this compendium educates, enthralls, and stimulates the readers to look to the future possibilities in this rapidly evolving field.

Post-transcriptional Control of Gene Expression

Author: Orna Resnekov

Publisher: Springer Science & Business Media

Published: 2013-06-29

Total Pages: 276

ISBN-13: 3642609295

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Many important cellular processes rely on posttranscriptional control of gene expression. This book describes the mechanisms of gene expression at this level that occur in the cytoplasm of prokaryotes and eukaryotes. Several introductory chapters discuss the general principles of translation and mRNA stability. The interactions of mature mRNA with the translational machinery, the components of mRNA degradation and antisense RNA are surveyed. Subsequent chapters discuss protein folding, transport, modification and degradation. The book is an invaluable source of information for both newcomers and those wishing an overview of the field.

Emerging Technologies for Nutrition Research

Author: Institute of Medicine

Publisher: National Academies Press

Published: 1997-09-03

Total Pages: 729

ISBN-13: 0309174538

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The latest of a series of publications based on workshops sponsored by the Committee on Military Nutrition Research, this book's focus on emerging technologies for nutrition research arose from a concern among scientists at the U.S. Army Research Institute of Environmental Medicine that traditional nutrition research, using standard techniques, centered more on complex issues of the maintenance or enhancement of performance, and might not be sufficiently substantive either to measure changes in performance or to predict the effects on performance of stresses soldiers commonly experience in operational environments. The committee's task was to identify and evaluate new technologies to determine whether they could help resolve important issues in military nutrition research. The book contains the committee's summary and recommendations as well as individually authored chapters based on presentations at a 1995 workshop. Other chapters cover techniques of body composition assessment, tracer techniques for the study of metabolism, ambulatory techniques for the determination of energy expenditure, molecular and cellular approaches to nutrition, the assessment of immune function, and functional and behavioral measures of nutritional status.

Post-Transcriptional Gene Regulation by N6-Methyladenosine and Selective RNA Binding Proteins

Author: Ian A. Roundtree

Publisher:

Published: 2017

Total Pages: 137

ISBN-13: 9780355519198

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Regulation of genetic output is a complex biological phenomenon that allows cells with identical genetic material to enable diverse phenotypic outcomes. Epigenetics is the study of factors that change gene expression without perturbing the underlying genetic sequence. Mechanisms of epigenetics feature a multitude of chemical modifications to DNA as well as accompanying histone proteins, which tune the transcriptional output in a reversible manner. Recently, the concept of reversible RNA epigenetics has emerged as a mechanism to regulate gene expression post-transcriptionally. N6-methylasdenosein (m6A) is the most common internal modification in eukaryotic messenger RNA (mRNA). This RNA modification is recognized by m6A-selective RNA binding protein of the YTH family, which incorporate modified RNAs into canonical pathways for mRNA metabolism. In this work, we describe the function of the only nuclear YTH protein YTHDC1 in promoting the nuclear export of methylated mRNAs by interaction with the splicing and export adaptor protein SRSF3. We then turn to a biological example of rapid mRNA processing during progression through the cell cycle. We propose that m6A modifications serve roles in the dynamic regulation of the cellular transcriptome.