Harper's Textbook of Pediatric Dermatology, 2 Volume Set

Harper's Textbook of Pediatric Dermatology, 2 Volume Set PDF

Author: Peter H. Hoeger

Publisher: John Wiley & Sons

Published: 2019-12-16

Total Pages: 0

ISBN-13: 1119142199

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A consummate classic with a fresh approach to pediatric dermatology Children ́s skin is different. Maturation affects the epidermal barrier, the cutaneous microbiome, adnexal structures, vasculature, and transcutaneous absorption of drugs. The immature skin is more susceptible to pathogens and environmental disruption. Many genetic disorders are either present at birth or manifest early in childhood. Skin diseases thus present differently in children than in adults. Pediatric dermatology has seen significant advances over the last decade, particularly in the field of molecular genetics research, which has furthered our understanding of the pathogenesis of many skin diseases and the development of new approaches to treatment. This fourth edition of the Harper classic provides state-of-the-art information on all aspects of skin disease in children. It covers the diagnosis and treatment of all conditions - both common and rare - with a consistently evidence-based approach. Existing content has been refreshed and fully updated to reflect emerging thinking and to incorporate the latest in research and clinical data - especially at the genetic level. This new fourth edition includes: Greater focus on the genetics behind skin disease, including new genes/genodermatoses, progress in genetic analysis, and stem cell transplants Increased coverage of lasers and other technologies used to treat skin disease More summary tables, learning points, tables of differential diagnosis, and clinical algorithms for diagnosis and management Additional online features, including patient information links and multiple choice questions Harper's Textbook of Pediatric Dermatology delivers crucial clinical insights and up-to-date research information that spans the breadth of the field. As the most comprehensive reference book on this subject available, this revised fourth edition will support and guide the daily practice of both dermatologists and pediatricians across the world.

Morphogenesis of Skin Pattern Geometry in Birds

Morphogenesis of Skin Pattern Geometry in Birds PDF

Author: Camille Curantz

Publisher:

Published: 2020

Total Pages: 0

ISBN-13:

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Natural patterns constitute one of the most diverse features observed in wild animals. The development of such patterns requires a series of morphogenetic events involving a differential response of a naïve tissue to chemical and mechanical positional cues. To what extent these processes contribute to the shape of the natural variation remains unclear. In birds, feather primordia are implanted in typical geometries which vary between birds in primordia size, spacing and pattern regularity. It has been shown that the development of the feather array surely involves self-organising processes. Such processes rely on molecular and cellular factors that cumulate and cooperate temporally and spatially in the developing skin. We showed that the patterning of feather primordia involves prior regionalisation of the skin into competent domains forming a specie-specific pre-pattern that influences the resulting pattern. The comparative description of the local variation of the feather array in these birds according to their initial competent domains shows that variation in the amplitude of dermal cell anisotropy correlates with variation in pattern regularity. Using ex vivo perturbations of skin architecture by an inhibitor of actin filament polymerisation, I showed that the anisotropy of dermal cells prior to feather primordia formation can be seen a readout of the competent state of the tissue to form a regular pattern. These results provide insights into the cellular basis of self-organisation and demonstrate that tissue morphology, constrain the cell response to the positional cues and contribute to shape the variation of the geometry of the feather array observed in nature.

Molecular Basis of Epithelial Appendage Morphogenesis

Molecular Basis of Epithelial Appendage Morphogenesis PDF

Author: Cheng-Ming Chuong

Publisher: Landes Bioscience

Published: 1998

Total Pages: 468

ISBN-13:

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Reviews recent experimental findings and current thinking on epithelial appendage morphogenesis. Contains sections on overview, morphogenesis of epithelial appendages on the body surface and within the body, molecular mechanisms, models, and approaches. Specific subjects include early molecular events in feather morphogenesis, evolutionarily conserved gene interactions, and molecular biology of anhidrotic ectodermal dysplasia. Many chapters contain summary diagrams of the formative process of organs, with cellular and molecular explanations. Annotation copyrighted by Book News, Inc., Portland, OR