Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters

Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters PDF

Author: M. Morad

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 586

ISBN-13: 9401139903

DOWNLOAD EBOOK →

Knowledge of cardiac ion channels and transporters has advanced remarkably in the last two decades with the development of patch-clamp and molecular biological techniques. This textbook offers a comprehensive overview of structures and functions of ion channels and transporters in the heart. Readers are first introduced to the molecular biology and electrophysiology of all the important ion channels. After discussing their developmental changes, the pharmacology and pathophysiology of clinically-relevant ion channels are reviewed. Molecular aspects of the cardiac excitation-contraction coupling and intracellular Ca2+ regulation by ion transporters are also described. The book will be useful to electrophysiologists, cardiac physiologists and pharmacologists, and molecular biologists interested in ion channels at all levels. For research specialists, the book will provide a perspective of the field. The book can be used as a reference source for working scientists in the fields of ion channels, biophysics, cardiac electrophysiology, and pharmacology. It is aimed at graduate and medical students, designed for use as a textbook for graduate and medical courses.

Heart Rate and Rhythm

Heart Rate and Rhythm PDF

Author: Onkar N. Tripathi

Publisher: Springer Nature

Published: 2023-12-08

Total Pages: 581

ISBN-13: 3031335880

DOWNLOAD EBOOK →

This completely updated and expanded 2nd Edition provides all the information needed in order to understand the complex molecular, cellular and genetic mechanisms that underlie normal and abnormal cardiac rhythms. Its goal is to help physiologists and clinicians alike develop better preventive and treatment strategies. The respective chapters cover a broad range of topics, including the role of specific ion channels and transporters, gap junctions, intracellular Ca2+ handling in pacemaker activity, impulse conduction, and the activity of atrial and ventricular myocardium. Special emphasis is placed on the unique electrophysiology of specialized pacemaking cells and conducting fibers. In turn, several types of inherited and acquired ventricular arrhythmias are presented in detail. Clinicians will especially appreciate the updated information on even common disorders like atrial fibrillation and their impacts on human physiology. In closing, the book goes “one step further” and considers future prospects, e.g. novel antiarrhythmic agents and new concepts like optogenetics, in the context of heart rate regulation. Accordingly, it offers readers a solid reference guide to everything they need to know about human heart rate and rhythm.

Cardiac Ion Channels

Cardiac Ion Channels PDF

Author: Andreas E. Busch

Publisher: S. Karger AG (Switzerland)

Published: 1999-01-01

Total Pages: 112

ISBN-13: 9783805570121

DOWNLOAD EBOOK →

The present volume is dedicated to important cardiac ion channels, their function in (patho-)physiology and their pharmacology. The reviews included provide the most recent update on research on these putative drug targets for arrhythmias, coronary heart disease and heart failure. However, as the number of identified cardiac ion channel genes is enormous and a lot of research still remains to be done, the publication at hand can only cover a small portion of them in detail. The identification of an ion channel gene is only the first step towards the understanding of the role and function of a particular channel. Following the identification of a novel gene and its basic channel properties, the analysis of its tissue distribution, the regulation of protein function and expression under physiological and pathophysiological conditions as well as the composition of the channel complex (is it a hetero- or homopolymeric channel) will play a crucial role in establishing a channel as a putative new drug target. Many of these criteria are covered by the reviews in this publication, helping the researcher to keep up with developments in this complex field of research.

Heart Rate and Rhythm

Heart Rate and Rhythm PDF

Author: Onkar N. Tripathi

Publisher: Springer Science & Business Media

Published: 2011-05-02

Total Pages: 676

ISBN-13: 3642175759

DOWNLOAD EBOOK →

Pathological heart rhythms are a major health issue. In this book experts from various fields provide an important context for understanding the complicated molecular and cellular mechanisms that underlie normal and pathophysiological cardiac rhythms. Individual chapters cover a full range of topics, including the ionic basis of pacemaking, the role of specific channels and transporters in sinoatrial node pacemaking, altered intracellular Ca2+ handling in response to disease, computer modeling of the action potentials of pacemaker and working cardiomyocytes, genetic and molecular basis of inherited arrhythmias and a review of established and novel antiarrhythmic agents. Due to the key importance of the specialized pacemaker cells and tissue (sinoatrial and atrioventricular nodes) in maintaining heart rate and rhythm, special emphasis is placed on the peculiar electrophysiology of these cells.

Cardiac Repolarization

Cardiac Repolarization PDF

Author: Ihor Gussak

Publisher: Springer Science & Business Media

Published: 2003-03-13

Total Pages: 549

ISBN-13: 1592593623

DOWNLOAD EBOOK →

A comprehensive review of all the latest developments in cardiac electrophysiology, focusing on both the clinical and experimental aspects of ventricular repolarization, including newly discovered clinical repolarization syndromes, electrocardiographic phenomena, and their correlation with the most recent advances in basic science. The authors illuminate the basic electrophysiologic, molecular, and pharmacologic mechanisms underlying ventricular repolarization, relate them to specific disease conditions, and examine the future of antiarrhythmic drug development based on both molecular and electrophysiological properties. They also fully review the clinical presentation and management of specific cardiac repolarization conditions.

Anesthetic Pharmacology

Anesthetic Pharmacology PDF

Author: Alex S. Evers

Publisher: Cambridge University Press

Published: 2011-03-10

Total Pages: 2902

ISBN-13: 1139497022

DOWNLOAD EBOOK →

In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period.

Calcium Entry Channels in Non-Excitable Cells

Calcium Entry Channels in Non-Excitable Cells PDF

Author: Juliusz Ashot Kozak

Publisher: CRC Press

Published: 2017-07-14

Total Pages: 343

ISBN-13: 149875273X

DOWNLOAD EBOOK →

Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.

Voltage Gated Sodium Channels

Voltage Gated Sodium Channels PDF

Author: Peter C. Ruben

Publisher: Springer Science & Business Media

Published: 2014-04-15

Total Pages: 328

ISBN-13: 3642415881

DOWNLOAD EBOOK →

A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.

Lanterna Rally - Theme by Grace Themes