Molecular Mechanisms of Skin Aging and Age-Related Diseases

Molecular Mechanisms of Skin Aging and Age-Related Diseases PDF

Author: Taihao Quan

Publisher: CRC Press

Published: 2016-04-21

Total Pages: 263

ISBN-13: 1498704654

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Our skin changes as we age. It becomes thinner and loses fat, making it less plump and smooth. Clinically, aged skin is characterized by wrinkles, sagging, age spots and dryness. Emphasizing laboratory and clinical research, this book comprehensively describes the molecular mechanisms of human skin-aging and age-related skin diseases. This includes molecular understanding of the development of aging skin and its prevention as well as mechanisms-based clinical rejuvenation. The book also focuses on research to develop mechanisms-based anti-skin-aging products.

Molecular Mechanisms of the Aging Process and Rejuvenation

Molecular Mechanisms of the Aging Process and Rejuvenation PDF

Author: Naofumi Shiomi

Publisher: BoD – Books on Demand

Published: 2016-08-31

Total Pages: 128

ISBN-13: 9535125680

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Numerous studies had been performed to elucidate the mechanisms of aging and to achieve rejuvenation, with some success reported in recent years. However, at present, the findings from those studies are not sufficient to resolve the issue of aging. This book presents an overview of recent topics on cellular aging and rejuvenation. In the early chapters, the molecular mechanisms of aging via the activities of clock and ion channel proteins, in addition to overall aspects, are discussed. In the latter part, the aging of the skin, immune system, and brain is discussed. This book will prove useful for those studying or developing new drugs to counter the aging process and will encourage the development of novel ideas for rejuvenation.

Cell Aging: Molecular Mechanisms and Implications for Disease

Cell Aging: Molecular Mechanisms and Implications for Disease PDF

Author: Christian Behl

Publisher: Springer Science & Business Media

Published: 2013-12-18

Total Pages: 113

ISBN-13: 3642451799

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Aging represents a physiological and per se non-pathological and multifactorial process involving a set of key genes and mechanisms being triggered by different endogenous and exogenous factors. Since aging is a major risk factor in connection with a variety of human disorders, it is increasingly becoming a central topic in biochemical and medical research. The plethora of theories on aging – some of which have been discussed for decades – are neither isolated nor contradictory but instead can be connected in a network of pathways and processes at the cellular and molecular levels. This book summarizes the most prominent and important approaches, focusing on telomeres, DNA damage and oxidative stress as well as on the possible role of nutrition, the interplay between genes and environment (epigenetics) and intracellular protein homeostasis and introduces some genes that have actually extended life spans in animal models. Linking these different determinants of aging with disease, this volume aims to reveal their multiple interdependencies. We see that there is no single “perfect” theory of aging and that instead it is possible to define what the authors call the molecular aging matrix of the cell. A better knowledge of its key mechanisms and the mutual connections between its components will lead to a better understanding of age-associated disorders such as Alzheimer’s disease.

Molecular Basis for the Aging of Human Skin

Molecular Basis for the Aging of Human Skin PDF

Author: Taihao Quan

Publisher:

Published: 2017

Total Pages: 0

ISBN-13: 9781536124682

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Skin is the most voluminous connective tissue of the body. Skin, like all other human organs, undergoes progressive alterations as a consequence of the passage of time (natural aging). However, human skin, unlike other organs, continuously experiences harmful exposure from environmental sources such as solar ultraviolet irradiation (photoaging). As the bulk of the skin is largely comprised of connective tissue collagen, the primary molecular features of aged human skin are reduced production of collagen and accumulation of damaged collagen. Age-related alterations of dermal connective collagen cause an aberrant tissue microenvironment, which deleteriously influence the risk of developing age-related skin diseases. This book comprehensively describes the molecular mechanisms of human skin connective tissue aging by emphasizing age-related dermal microenvironment as a strategy for improving our quality of life as well as for preventive and therapeutic intervention of age-related skin diseases. This book is an essential resource for the development of mechanisms-based anti-skin aging products.

Skin Aging

Skin Aging PDF

Author: Barbara A. Gilchrest

Publisher: Springer Science & Business Media

Published: 2006-04-20

Total Pages: 205

ISBN-13: 3540329536

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The topic of skin aging is of growing importance to all working in the field of dermatology, aesthetic medicine and cosmetic medicine. Two internationally well-known and leading experts in the field present a comprehensive state-of-the-art review on all aspects of skin aging. With its clear, concise and reader-friendly format this book has all the potential to become the Bible of skin aging. Every specialist interested in dermatology, aesthetic medicine, cosmetic science, cutaneous biology and aging research will find indispensable information of great value for his or her daily work.

Molecular Mechanisms of Aging

Molecular Mechanisms of Aging PDF

Author: Konrad Beyreuther

Publisher: Springer

Published: 1990-07-23

Total Pages: 220

ISBN-13:

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A high-level text on the molecular and genetic aspects of human ageing with reference to cognitive functions and age-related diseases."

Models, Molecules and Mechanisms in Biogerontology

Models, Molecules and Mechanisms in Biogerontology PDF

Author: Pramod C. Rath

Publisher:

Published: 2019

Total Pages:

ISBN-13: 9789811335860

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This book examines the basic cellular and molecular mechanisms associated with aging. It comprehensively describes the genetic, epigenetic, biochemical and metabolic regulation of aging, as well as some important age-related diseases. Divided into two major sections, it takes readers through the various aspects of aging in a story-like manner and suggests various interventions for healthy aging, such as dietary restriction, regular exercise, nutrition and maintaining a balanced and a non-stressful lifestyle. It describes the implications of aging on the nervous system, metabolism, immunity and stem cells as well as care for the elderly. The book is an ideal companion for both new and established researchers in the field and is also useful for educators, clinicians and policy makers.

The Molecular Basis for the Aging of Human Skin

The Molecular Basis for the Aging of Human Skin PDF

Author: Taihao Quan

Publisher:

Published: 2017

Total Pages: 240

ISBN-13: 9781536124699

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Skin is the most voluminous connective tissue of the body. Skin, like all other human organs, undergoes progressive alterations as a consequence of the passage of time (natural aging). However, human skin, unlike other organs, continuously experiences harmful exposure from environmental sources such as solar ultraviolet irradiation (photoaging). As the bulk of the skin is largely comprised of connective tissue collagen, the primary molecular features of aged human skin are reduced production of collagen and accumulation of damaged collagen. Age-related alterations of dermal connective collagen cause an aberrant tissue microenvironment, which deleteriously influence the risk of developing age-related skin diseases. This book comprehensively describes the molecular mechanisms of human skin connective tissue aging by emphasizing age-related dermal microenvironment as a strategy for improving our quality of life as well as for preventive and therapeutic intervention of age-related skin diseases. This book is an essential resource for the development of mechanisms-based anti-skin aging products.

Textbook of Aging Skin

Textbook of Aging Skin PDF

Author: Miranda A. Farage

Publisher: Springer Science & Business Media

Published: 2009-12-02

Total Pages: 1255

ISBN-13: 3540896554

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This comprehensive ‘Major Reference Book’ compiles all current and latest information on aging skin in a two-volume set. Highly structured with a reader-friendly format, it covers a wide range of areas such as basic sciences, the different diseases and conditions which occur with aging (from malignant to non-malignant), the latest techniques and methods being used such as bioengineering methods and biometrics as well as toxicological and safety considerations for the elderly population. It also illustrates the global consumers’ sociological and psychological implications, ethnicity and gender differences and includes marketing considerations for this elderly group. This unique and comprehensive guide will become the main reference textbook on this topic.

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