Molecular Genetics of Mycobacteria

Molecular Genetics of Mycobacteria PDF

Author: Graham F. Hatfull

Publisher: John Wiley & Sons

Published: 2020-08-06

Total Pages: 832

ISBN-13: 1555818846

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A comprehensive collection of perspectives by experts in mycobacterial molecular biology Mycobacterium tuberculosis causes one in four avoidable deaths in the developing world and kills more adults than malaria, AIDS, and all tropical diseases combined. Tuberculosis was named a global health emergency by the World Health Organization, a distinction no other disease has received. Although the study of mycobacterial genetics has expanded dramatically, with new investigations into mycobacterial growth, replication, metabolism, physiology, drug susceptibility, and virulence, most of the problems in tuberculosis control that existed in 2000 remain today. Advances in our understanding of mycobacterial genetics have been reflected in exciting recent developments. New diagnostic approaches can identify drug resistance within a few hours, promising new drugs are progressing through the pipeline and into the clinic, and a range of newly developed vaccines are being evaluated. It is an exciting time as the fruits of 30 years of intensive genetic investigation are finally beginning to emerge. Written by leading experts in the field, Molecular Genetics of Mycobacteria, Second Edition, Discusses key areas of current research in mycobacterial genetics Explains the genetics of the physiology, metabolism, and drug sensitivities of M. tuberculosis Presents genetic approaches for manipulating M. tuberculosis This book is an invaluable resource for anyone interested in the molecular genetics and molecular biology of mycobacteria.

Molecular Genetics of Bacteria

Molecular Genetics of Bacteria PDF

Author: Larry Snyder

Publisher: Wiley-Blackwell

Published: 2003

Total Pages: 590

ISBN-13:

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This advanced level textbook offers an in-depth look at molecular biology and biochemistry. The breadth and diversity of bacterial genetics are explored in discussions of microbial systems beyond the much-studied E Coli.

Mycobacterium

Mycobacterium PDF

Author: Tanya Parish

Publisher: Taylor & Francis

Published: 2005

Total Pages: 351

ISBN-13: 9781904933144

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Millions of people die each year from tuberculosis and millions more are infected. The emergence of drug-resistant forms of Mycobacteriumcombined with the paucity of new drugs makes the study of the molecular biology of this organism especially urgent. In this book expert researchers critically review the current and most recent advances in this vitally important subject. The focus is on the topical and most relevant aspects of mycobacterial molecular biology and the book aims to give readers an insight into the current understanding of the subject and the future direction of research. Chapters include sections on future trends, web resources and useful reference sections. Among the topics covered are DNA replication, cell division, regulatory systems, protein export, drug resistance, vaccine technology, and much, much more. Essential reading for scientists and researchers working on mycobacteria and a recommended text for all microbiology laboratories.

Molecular Biology of the Mycobacteria

Molecular Biology of the Mycobacteria PDF

Author: Johnjoe McFadden

Publisher: Academic Press

Published: 1990

Total Pages: 252

ISBN-13:

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Based on a meeting held at the University of Surrey in September 1989, this book details progress in search since the first reports of cloning of mycobacterial genes were published some five years ago. Mycobacteriologists, bacterial geneticists, and those with an interest in microbial pathogenesis will find this volume to be invaluable.

Mycobacteria

Mycobacteria PDF

Author: C. Ratledge

Publisher: John Wiley & Sons

Published: 2009-04-01

Total Pages: 416

ISBN-13: 1444311441

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Tuberculosis continues to kills more people than any other single infective agent. The resurgence of the disease in many countries has produced a heightened awareness of the threat posed by mycobacterial infections. At the same time, there has been an explosion of knowledge of the fundamental properties of mycobacteria, most notably the determination of the complete genome sequence of Mycobacterium tuberculosis. This book provides an up-to-date account of these developments in the molecular biology and immunology of mycobacteria, coupled with allied advances of a more applied nature, such as the use of molecular techniques for diagnosis and epidemiological investigations. With chapters contributed from an international team of experts, it will not only be an essential reference text for the expanding mycobacterial research community, but also will find a prominent place on the shelves of clinicians, infectious disease and public health specialists, diagnostic laboratories, postgraduate students and indeed anyone concerned with the management and investigation of outbreaks of tuberculosis. Comprehensively covers recent advances in the molecular biology of the mycobacteria. First book to be published on this subject since the publishing of the complete genome for the tubercle bacillus (M. tuberculosis). Coincides with a worldwide resurgence of tuberculosis.

Mycobacterium

Mycobacterium PDF

Author: Tanya Parish

Publisher: Caister Academic Press Limited

Published: 2009

Total Pages: 0

ISBN-13: 9781904455400

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In this book, expert scientists critically review the current and most recent advances in the genomics and molecular biology of mycobacteria. With the focus being on the topical and most relevant aspects, the contributors provide insight into the current understanding of the subject and the future direction of research. Topics covered include strain variation and evolution, hypervirulent strains, electron transport and respiration, lipid biosynthesis, DNA repair, oxygen signaling, sulphur metabolism, protein secretion, the protein kinase family, and much more. This is a valuable reference text for all microbiology laboratories and is essential reading for all scientists and researchers involved with mycobacteria.

Molecular Mycobacteriology

Molecular Mycobacteriology PDF

Author: Robert A. Ollar

Publisher: CRC Press

Published: 1999-01-04

Total Pages: 372

ISBN-13: 9780824702403

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This work presents an overview of the clinical pathology of mycobacterial and nonpathogens, data on genetically based methodologies for clinical testing, straightforward protocols for molecular manipulations, and theoretical explanations of the molecular mechanisms involved. It explains the safest and most efficient methods for detecting mycobacterium avium complex, providing the means to combat this common secondary opportunistic infection in AIDS patients.