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Molecular Diagnosis and Targeting for Gynecologic Malignancy

Author: Seiji Isonishi

Publisher: Springer Nature

Published: 2021-03-05

Total Pages: 171

ISBN-13: 9813360135

This book summarizes the important developments in the field of cancer research, specifically uterine cervical/endometrial cancer and ovarian cancer. It highlights the recent advances in gynecologic cancer, such as next generation models of genetically engineered animal models or cancer cell lines, focusing on their significance for advancing our understanding of gynecologic cancer biology, prevention and treatment, and drug response and resistance. Cancer research in the area of gynecologic tumors has undergone an enormous transformation over the past decade, with a greater understanding of tumor biology, elucidation of novel targets for therapeutic intervention, and better recognition of genetic predisposition syndromes. At the same time, the recent advances in basic cancer research have provided key insights into all aspects of gynecologic cancer biology, including developmental pathways and the impact of lineage plasticity, understanding metastatic progression, uncovering the roles of the tumor microenvironment , exploring tumor evolution, and discovering new therapeutic approaches and mechanisms of drug sensitivity and adaptive response. Molecular Diagnosis and Targeting for Gynecologic Malignancy appeals to investigators, clinicians, residents and postdocs who are curious about new research on gynecologic malignancies. It not only presents basic and translational research, but also explores the generalizability of the evidence covering the interface between basic and clinical science. Furthermore, a number of the topics offer the basis for new ideas that have the potential to advance into the gynecologic malignancies. This book provides readers with state-of-the-art information that will help improve the lives of patients with these challenging diseases.

Noninvasive Molecular Markers in Gynecologic Cancers

Author: Debmalya Barh

Publisher:

Published: 2023-12-31

Total Pages: 0

ISBN-13: 9781138749504

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In cancer treatment, non-invasive diagnosis can avoid complications of biopsy and other unfavorable impacts on patient's health. DNA, methylation, SNPs, miRNA, mRNA, protein, autoantibodies, metabolite, and Omics-based markers from remote media such as blood, plasma, and urine are emerging as noninvasive molecular markers with high specificity and sensitivity towards many cancers. In many instances, these markers are also emerging as next-generation personalized diagnostics and targets or therapeutics for personalized cancer treatment. This book classifies the available molecular tumor markers according to their principal characteristics and relative methodologies.

Gynecological Cancers

Author: Antonio Giordano

Publisher: Springer

Published: 2016-07-12

Total Pages: 173

ISBN-13: 3319329073

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Facilitating the collaboration between the basic, translational, and clinical sciences, this book provides an overview of the genetic and epigenetic mechanisms underlying the formation and progression of gynecological cancers. Gynecological Cancers: Genetic and Epigenetic Targets and Drug Development gathers all of the molecular and cellular aspects of gynecological cancer together within one volume, providing detailed and up-to-date information on the etiology, diagnosis, and treatment of gynecological cancers. Gynecological Cancers: Genetic and Epigenetic Targets and Drug Development also discusses the racial and ethnic disparities in the treatment of gynecological cancers through cost effective modalities like single visit screening and diagnosis, well women clinics, and mobile clinics. Written and edited by leaders in the field, this volume within the Current Clinical Oncology series is an indispensable resource for today’s practicing oncologist.

Diagnosis and Treatment of Rare Gynecologic Cancers

Author: Michael Frumovitz

Publisher: Elsevier Health Sciences

Published: 2022-05-10

Total Pages: 387

ISBN-13: 0323829392

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Offering a one-stop guide to recognition and therapeutic decision making, Diagnosis and Treatment of Rare Gynecologic Cancers fills a gap in the medical literature on uncommon ovarian, uterine, cervical, and vulvovaginal cancers and trophoblastic diseases. This authoritative text, edited by Drs. Michael Frumovitz, Mario Leitao, and Preetha Ramalingam, has been authored by internationally recognized experts from top institutions such as MD Anderson Cancer Center and Memorial Sloan Kettering Cancer Center. Each chapter covers different cancer subtypes and has been reviewed by an oncologist and a pathologist. Provides up-to-date clinical guidance on assessment and therapeutic options for patients with rare gynecologic malignancies. Presents information in a templated, easy-to-read format. Each chapter includes an introductory clinical case followed by epidemiology of disease, pathologic assessment, basic science/molecular/translational research, work-up of newly diagnosed disease, staging, treatment of newly diagnosed disease, treatment of recurrent disease, potential therapeutic targets, and a case resolution. Includes diagnostic and treatment algorithms for each form of cancer. Contains numerous anatomical figures, radiographs, photographs, and tables for quick visual reference.

Principles and Practice of Gynecologic Oncology

Author: Dennis S. Chi

Publisher: LWW

Published: 2017

Total Pages: 0

ISBN-13: 9781496340023

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Sect. I: Etiology, prevention, and molecular biology -- Epidemiology of gynecologic cancers -- Molecular pathogenesis of gynecologic cancers -- Hereditary gynecologic cancers -- Invasion, metastasis, and angiogenesis -- Development and identification of tumor serum markers -- Cancer prevention strategies -- Preinvasive disease of the lower genital tract -- Sect. II: Diagnostic and therapeutic modalities -- Perioperative and critical care -- Surgical principles in gynecologic oncology -- Diagnostic imaging -- Biologic and physical principles of radiation oncology -- Targeted therapies in gynecologic cancers -- Principles of chemotherapy in gynecologic cancer -- Pharmacology and therapeutics in gynecologic cancer -- Immunotherapy of gynecologic malignancies -- Clinical trials methodology and biostatistics -- Cost-effective and value-based gynecologic cancer care -- Sect. III: Disease sites -- Vulva -- Vaginal cancer -- Cervix uteri -- Corpus: epithelial tumors -- Corpus: mesenchymal tumors -- Epithelial ovarian cancer -- Overian germ cell tumors -- Overian sex cord-stromal tumors -- Gestational trophoblastic disease: molar pregnancy and gestational trophoblastic neoplasia -- Sect. IV: Special management topics -- Breast cancer -- Management of infection in patients with gynecologic malignancy -- Management of surgical complications of gynecologic cancer treatment -- Management of pain -- Nutrition support of patients with gynecologic cancer -- Palliative and supportive care

Ovarian Cancer Biomarkers

Author: Khalid El Bairi

Publisher: Springer Nature

Published: 2021-10-09

Total Pages: 236

ISBN-13: 9811618739

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This book comprehensively summarizes the biology, etiology, and pathology of ovarian cancer and explores the role of deep molecular and cellular profiling in the advancement of precision medicine. The initial chapter discusses our current understanding of the origin, development, progression and tumorigenesis of ovarian cancer. In turn, the book highlights the development of resistance, disease occurrence, and poor prognosis that are the hallmarks of ovarian cancer. The book then reviews the role of deep molecular and cellular profiling to overcome challenges that are associated with the treatment of ovarian cancer. It explores the use of genome-wide association analysis to identify genetic variants for the evaluation of ovarian carcinoma risk and prognostic prediction. Lastly, it highlights various diagnostic and prognostic ovarian cancer biomarkers for the development of molecular-targeted therapy.

Diagnosis and Treatment of Rare Gynecologic Cancers

Author: Michael Frumovitz

Publisher: Elsevier

Published: 2022-08

Total Pages: 0

ISBN-13: 9780323829380

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Overcoming Drug Resistance in Gynecologic Cancers

Author:

Publisher: Elsevier

Published: 2021-08-17

Total Pages: 388

ISBN-13: 012824299X

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Overcoming Drug Resistance in Gynecologic Cancers provides up-to-date information related to important gynecologic cancers and focuses on mechanisms of drug resistance, genetics, signaling, immunology, health disparities, nanotechnology, economic considerations and financial impacts. The book covers not only drug resistance but also important means to reverse resistance both in the laboratory and clinic. The book discusses topics such as lifestyle, nutrition and risk of gynecologic cancers, the financial impact of drug resistance, chemosensitizing agents and targeted therapies in cervical, endometrial and ovarian cancer, immunotherapy to overcome drug resistance, and genetic polymorphisms in gynecologic cancers. Additionally, it discusses ethnic and racial health disparity perspectives and future developments in chemosensitizing activities to reverse drug resistance in gynecologic cancers. It is a valuable resource for cancer researchers, oncologists, clinicians and other biomedical field members who are interested in new approaches to improve chemotherapy outcome in patients with gynecologic cancers. Provides a comprehensive resource with all the details needed for readers to understand and follow information Encompasses schematics, diagrams and flow charts in all chapters to help readers easily follow critical information Presents tables and figures especially developed to summarize the information with appropriate statistical rigor and to show details of clinical specimens such as pathological, radiological characteristics, and/or laboratory biomarkers

Recent Advances in Endometrial Cancer

Author: Sumita Mehta

Publisher: Springer Nature

Published: 2020-07-23

Total Pages: 306

ISBN-13: 9811553173

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This book discusses in detail the recent advances in the management of endometrial cancer, including the latest therapies and diagnostic methods. The book focuses on treatment-oriented topics such as the role of lymphadenectomy and sentinel node dissection, surgical complications, radiation techniques, and chemotherapy in endometrial cancer, and also explores treatment options in advanced disease stages, including hormonal therapy and targeted therapy. Providing insights into the evidence-based management guidelines for endometrial cancer, this book is a valuable resource for students, trainees and practitioners in the field of gynecology and gyne-oncology.

Clinical Gynecology

Author: Eric J. Bieber

Publisher: Cambridge University Press

Published: 2015-04-23

Total Pages: 1127

ISBN-13: 1107040396

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Written with the busy practice in mind, this book delivers clinically focused, evidence-based gynecology guidance in a quick-reference format. It explores etiology, screening, tests, diagnosis, and treatment for a full range of gynecologic health issues. The coverage includes the full range of gynecologic malignancies, reproductive endocrinology and infertility, infectious diseases, urogynecologic problems, gynecologic concerns in children and adolescents, and surgical interventions including minimally invasive surgical procedures. Information is easy to find and absorb owing to the extensive use of full-color diagrams, algorithms, and illustrations. The new edition has been expanded to include aspects of gynecology important in international and resource-poor settings.