Modification of Tumor Development in Rodents
Author: Nobuyuki Itō
Publisher: S. Karger AG (Switzerland)
Published: 1991
Total Pages: 252
ISBN-13:
DOWNLOAD EBOOK →Author: Nobuyuki Itō
Publisher: S. Karger AG (Switzerland)
Published: 1991
Total Pages: 252
ISBN-13:
DOWNLOAD EBOOK →Author: Sandeep Kumar Singh
Publisher:
Published: 1988
Total Pages: 96
ISBN-13: 9789090020020
DOWNLOAD EBOOK →Author: Alecsandru Ioan Baba
Publisher:
Published: 2007
Total Pages: 787
ISBN-13: 9789732714577
DOWNLOAD EBOOK →Author: Marten H. Hofker
Publisher: Springer Science & Business Media
Published: 2008-02-04
Total Pages: 382
ISBN-13: 1592593402
DOWNLOAD EBOOK →Marten Hofker and Jan van Deursen have assembled a multidisciplinary collection of readily reproducible methods for working with mice, and particularlyfor generating mouse models that will enable us to better understand gene function. Described in step-by-step detail by highly experienced investigators, these proven techniques include new methods for conditional, induced knockout, and transgenic mice, as well as for working with mice in such important research areas as immunology, cancer, and atherosclerosis. Such alternative strategies as random mutagenesis and viral gene transduction for studying gene function in the mouse are also presented.
Author:
Publisher:
Published: 2001
Total Pages: 0
ISBN-13:
DOWNLOAD EBOOK →We have been using genetically predisposed mice to identify genes that can modify the risk of mammary tumor development. We have found that a congenic strain of mice that carries as a transgene a retroviral insertion of a LacZ-neoR gene (ROSA26 mice) on chromosome 6, are resistant to Min-induced mammary tumor development. In the ROSA26 mice, the insertion is flanked by about 25 cM of DNA derived from the 129 strain. In order to localize the locus or loci encoding the resistance, we produced mice carrying subsets of the 129 derived DNA form the congenic region. Analysis of six lines indicated that a strong modifier of mammary tumor development mapped within 2 cM of the ROSA26 insertion. This modifier also affects intestinal tumor growth. In addition, prepubertal female and male mice carrying the minimal modifier interval have a significantly smaller extent of mammary gland growth than do age-matched controls. Animals carrying the insertion have slower growth rates than wild-type mice. Finally, we have shown that the effect seen in the ROSA26 mice is due to the insertion and not to linked modifier loci.
Author: Rajesh Uthamanthil
Publisher: Academic Press
Published: 2016-10-13
Total Pages: 488
ISBN-13: 0128040610
DOWNLOAD EBOOK →Patient Derived Tumor Xenograft Models: Promise, Potential and Practice offers guidance on how to conduct PDX modeling and trials, including how to know when these models are appropriate for use, and how the data should be interpreted through the selection of immunodeficient strains. In addition, proper methodologies suitable for growing different type of tumors, acquisition of pathology, genomic and other data about the tumor, potential pitfalls, and confounding background pathologies that occur in these models are also included, as is a discussion of the facilities and infrastructure required to operate a PDX laboratory. Offers guidance on data interpretation and regulatory aspects Provides useful techniques and strategies for working with PDX models Includes practical tools and potential pitfalls for best practices Compiles all knowledge of PDX models research in one resource Presents the results of first ever global survey on standards of PDX development and usage in academia and industry
Author: Ian Tannock
Publisher: McGraw Hill Professional
Published: 2005
Total Pages: 596
ISBN-13: 9780071387743
DOWNLOAD EBOOK →This concise text examines cancer causation and biology as well as the biology underlying cancer treatment. Thoroughly updated and reorganized with five new chapters, the Fourth Edition emphasizes new development in molecular biology, hormone therapy, and the pharmacology of anti-cancer drugs. Features updated coverage of the basic science of radiotherapy and experimental radiation in addition to expansive coverage of new drugs developments.
Author: Robert C. Bast, Jr.
Publisher: John Wiley & Sons
Published: 2017-03-10
Total Pages: 2004
ISBN-13: 111900084X
DOWNLOAD EBOOK →Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates