Modern Modalities for the Diagnosis of Hematologic Neoplasms
Author: Chin-Yang Li
Publisher: Igaku-Shoin Medical Publishers
Published: 1996
Total Pages: 280
ISBN-13:
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Non-Neoplastic Hematologic Disorders
Author: Lubomir Sokol
Publisher: Springer
Published: 2024-11-09
Total Pages: 0
ISBN-13: 9783031623721
DOWNLOAD EBOOK →In the current digital era with the exponential growth of medical knowledge, voluminous textbooks have gradually been replaced by the pocketbooks with tables, figures, images, and e-links to digital book versions with supplemental materials available online. The advent of novel next-generation sequencing (NGS) and multi-omics single cell methods have uncovered causative molecular mechanisms in most of the known non-neoplastic hematologic disorders. There is an urgent need for a concise and up-to-date handbook focused on non-malignant hematology. The book describes characteristic clinical features and state-of-the-art diagnostic approaches of non-neoplastic hematologic disorders. It introduces modern molecular biomarkers with enormous diagnostic and prognostic value and novel targeted gene therapy. Differential diagnosis also includes relevant hematologic malignancies that could represent diagnostic pitfalls. Chapters include take home points for each disorder in concise and easy memorable manner. The book also provides diagnostic algorithms, novel prognostic and predictive factors, up-to-date treatment options, clinically relevant molecular signatures, and ongoing promising clinical trials if available. There are more than 100 questions and answers with comments on laboratory values, updated cytogenetic and mutational profiles. Non-Neoplastic Hematologic Disorders: A Quick Review of Modern Diagnostic and Therapeutic Approaches provides concise clinical and laboratory information about most common non-neoplastic hematologic disorder for practicing hematologists, oncologists, hematopathologists, molecular pathologists, internal medicine specialists, pediatricians, research nurses, nurse practitioners, and trainees at all levels.
Molecular Aspects of Hematologic Malignancies
Author: Michal Witt
Publisher: Springer Science & Business Media
Published: 2012-06-30
Total Pages: 468
ISBN-13: 3642294677
DOWNLOAD EBOOK →This book provides a state-of-the-art approach to the molecular basis of hematologic diseases and its translation into improved diagnostics and novel therapeutic strategies. Several representative hemato-oncologic malignancies are analyzed in detail: acute lymphoblastic leukemia, acute myeloid leukemia, B-cell Non-Hodgkin lymphomas, multiple myeloma, chronic lymphocytic leukemia, chronic myeloid leukemia, myelodysplastic syndromes, and myeloproliferative neoplasms. Experts in the field describe the molecular methods applied for modern diagnostics and therapies, such as hematopoietic stem cell transplantation, donor recipient matching, banking of biological material, analyses of post-transplant chimerism, and minimal residual disease monitoring. The volume concludes with an extensive section comprising thorough step-by-step protocols of molecular techniques in hematology, all of them validated in the authors’ own laboratories.
Flow Cytometry and Immunohistochemistry for Hematologic Neoplasms
Author: Tsieh Sun
Publisher: Lippincott Williams & Wilkins
Published: 2008
Total Pages: 362
ISBN-13: 9780781784009
DOWNLOAD EBOOK →This text is a detailed guide to the use of flow cytometry, immunohistochemistry, and molecular genetic techniques for diagnosis of hematologic neoplasms. Dr. Sun explains the principles of these techniques and demonstrates their utility in 39 clinical cases covering all important entities. Each case represents a comprehensive diagnostic approach including a clinical history and flow cytometric, immunohistochemical, and molecular genetic findings. Abundant full-color illustrations show histologic sections, immunohistochemical stains, bone marrow, peripheral blood, and body fluid smears, and each case includes a complete set of flow cytometric histograms. Over 100 tables compare and differentiate the diagnostic features of similar diseases. An image bank will be available on a companion Website.
Hematologic Malignancies
Author: Guy B. Faguet
Publisher: Springer Science & Business Media
Published: 2008-02-02
Total Pages: 365
ISBN-13: 1592590748
DOWNLOAD EBOOK →The aim of Hematologic Malignancies: Methods and Techniques is to review those methods most useful for the diagnosis and subsequent mana- ment of hematologic malignancies. The scope of coverage is intentionally broad, ranging from routine procedures to highly sophisticated methods not currently offered by most clinical laboratories. The latter methods were selected especially to bring into focus recent advances in molecular biology that, since they provide us with strong tools for assessing the outcome of upcoming therapeutic modalities intent on disease eradication, are expected to impact the future diagnosis and management of these diseases. Thus, the c- mon thread among all chapters is clinical relevance, whether sanctioned by past experience or by the expectation that seemingly esoteric research techniques of today will prove clinically valuable in the future. Hematologic Malignancies: Methods and Techniques is primarily a compilation of methods presented in sufficient detail—by authors with extensive expertise in their field—to serve not only as a reference for seasoned research and clinical laboratory pers- nel, but also as a guide for the less experienced. Moreover, the contributing authors also discuss the pathophysiologic bases and the diagnostic usefulness that underscore each method’s clinical relevance. Thus, this volume should be also valuable to clinicians—especially hematologists, oncologists, and path- ogists—often bewildered by an ever increasing flow of new scientific inf- mation, the practical application of which is often either not clearly disclosed or difficult to discern.
Childhood Cancer and Functional Impacts Across the Care Continuum
Author: National Academies of Sciences Engineering and Medicine
Publisher:
Published: 2021-09-09
Total Pages:
ISBN-13: 9780309683494
DOWNLOAD EBOOK →Since the late 1960s, the survival rate in children and adolescents diagnosed with cancer has steadily improved, with a corresponding decline in the cancer-specific death rate. Although the improvements in survival are encouraging, they have come at the cost of acute, chronic, and late adverse effects precipitated by the toxicities associated with the individual or combined use of different types of treatment (e.g., surgery, radiation, chemotherapy). In some cases, the impairments resulting from cancer and its treatment are severe enough to qualify a child for U.S. Social Security Administration disability benefits. At the request of Social Security Administration, Childhood Cancer and Functional Impacts Across the Care Continuum provides current information and findings and conclusions regarding the diagnosis, treatment, and prognosis of selected childhood cancers, including different types of malignant solid tumors, and the effect of those cancers on childrenâ (TM)s health and functional capacity, including the relative levels of functional limitation typically associated with the cancers and their treatment. This report also provides a summary of selected treatments currently being studied in clinical trials and identifies any limitations on the availability of these treatments, such as whether treatments are available only in certain geographic areas.
Hematology - E-Book
Author: Bernadette F. Rodak
Publisher: Elsevier Health Sciences
Published: 2013-12-27
Total Pages: 885
ISBN-13: 0323292690
DOWNLOAD EBOOK →Featuring hundreds of full-color photomicrographs, Hematology: Clinical Principles and Applications prepares you for a job in the clinical lab by exploring the essential aspects of hematology. It shows how to accurately identify cells, simplifies hemostasis and thrombosis concepts, and covers normal hematopoiesis through diseases of erythroid, myeloid, lymphoid, and megakaryocytic origins. This book also makes it easy to understand complementary testing areas such as flow cytometry, cytogenetics, and molecular diagnostics. Well-known authors Bernadette Rodak, George Fritsma, and Elaine Keohane cover everything from working in a hematology lab to the parts and functions of the cell to laboratory testing of blood cells and body fluid cells. Full-color illustrations make it easier to visualize complex concepts and show what you’ll encounter in the lab. Learning objectives begin each chapter, and review questions appear at the end. Instructions for lab procedures include sources of possible errors along with comments. Case studies provide opportunities to apply hematology concepts to real-life scenarios. Hematology instruments are described, compared, and contrasted. Coverage of hemostasis and thrombosis includes the development and function of platelets, the newest theories of normal coagulation, and clear discussions of platelet abnormalities and disorders of coagulation. A bulleted summary of important content appears at the end of every chapter. A glossary of key terms makes it easy to find and learn definitions. Hematology/hemostasis reference ranges are listed on the inside front and back covers for quick reference. Respected editors Bernadette Rodak, George Fritsma, and Elaine Keohane are well known in the hematology/clinical laboratory science world. Student resources on the companion Evolve website include the glossary, weblinks, and content updates. New content is added on basic cell biology and etiology of leukocyte neoplasias. Updated Molecular Diagnostics chapter keeps you current on techniques being used in the lab. Simplified hemostasis material ensures that you can understand this complex and important subject. Coverage of morphologic alteration of monocytes/macrophages is condensed into a table, as the disorders in this grouping are more of a biochemical nature with minimal hematologic evidence.
Flow Cytometry, Immunohistochemistry, and Molecular Genetics for Hematologic Neoplasms
Author: Tsieh Sun
Publisher: Lippincott Williams & Wilkins
Published: 2012-01-19
Total Pages: 449
ISBN-13: 1451180640
DOWNLOAD EBOOK →Immunophenotyping is the most powerful tool in the routine diagnosis of hematologic neoplasms. Immunohistochemical technique is used in histology labs for this purpose, while flow cytometry is used in clinical labs. Although separately these 2 techniques are very useful in detecting lymphomas and leukemias, the combination of both creates a very powerful and definitive diagnostic tool. The addition of molecular genetics to the book makes it an all-encompassing reference text.
Multiple Myeloma
Author: Morie A. Gertz
Publisher: Springer Science & Business Media
Published: 2013-10-01
Total Pages: 311
ISBN-13: 1461485207
DOWNLOAD EBOOK →This is a comprehensive, state-of-the-art guide to the diagnosis, treatment, and biology of multiple myeloma and related plasma disorders. Edited and written by a multidisciplinary group of recognized authorities from the Mayo Clinic, it presents clear guidelines on diagnosis and therapy and covers all aspects of multiple myeloma, from molecular classification and diagnosis, to risk stratification and therapy. Closely related plasma cell disorders such as solitary plasmacytoma, Waldenstrom macroglobulinemia, and light chain amyloidosis are discussed in detail as well. The book addresses often overlooked topics, including the role of radiation therapy, vertebral augmentation, and supportive care. Our understanding of this group of disorders is developing at an unprecedented rate, and Multiple Myeloma meets the need among oncologists and hematologists for a clear, timely, and authoritative resource on their biology, diagnosis, and treatment.
Multiparameter Flow Cytometry in the Diagnosis of Hematologic Malignancies
Author: Anna Porwit
Publisher: Cambridge University Press
Published: 2018-01-25
Total Pages: 248
ISBN-13: 1108548830
DOWNLOAD EBOOK →Master implementation of the techniques of flow cytometry in diagnosing complex haematological diseases and malignancies in patients, worldwide. Featuring World Health Organization recommendations on pre-analytical steps, instrument settings and panel construction, this invaluable manual offers invaluable support for those researching, practising and analyzing the cause of hematological malignancies. Authored by leading experts, this book puts flow-cytometry into everyday context. With a focus on multicolour panels, the manual provides readers an experienced understanding of effective, implementation techniques. Practitioners of all levels are offered a background in a variety of diseases presented alongside the most current methodology. Wide-ranging and comprehensive; detailed images of healthy blood, bone marrow and lymph-nodes are illustrated throughout, allowing for effective diagnosis. Through engaging with differential diagnoses, the manual offers an understanding of similar symptoms and mimicking malignancies, avoiding inaccurate results. Featuring in-depth descriptions of chronic diseases; users can reach accurate diagnosis, first time.
