Models of Obesity

Models of Obesity PDF

Author: Stanley J. Ulijaszek

Publisher: Cambridge University Press

Published: 2017-10-12

Total Pages: 249

ISBN-13: 1107117518

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Rationalities and models of obesity -- Energy balance, genetics and obesogenic environments -- Governance through measurement -- Inequalities -- Food and eating -- Global transformations of diet -- Obesity science and policy -- Complexity -- Systems and rationalities

Weight Management

Weight Management PDF

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2003-12-01

Total Pages: 277

ISBN-13: 0309089964

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The primary purpose of fitness and body composition standards in the U.S. Armed Forces has always been to select individuals best suited to the physical demands of military service, based on the assumption that proper body weight and composition supports good health, physical fitness, and appropriate military appearance. The current epidemic of overweight and obesity in the United States affects the military services. The pool of available recruits is reduced because of failure to meet body composition standards for entry into the services and a high percentage of individuals exceeding military weight-for-height standards at the time of entry into the service leave the military before completing their term of enlistment. To aid in developing strategies for prevention and remediation of overweight in military personnel, the U.S. Army Medical Research and Materiel Command requested the Committee on Military Nutrition Research to review the scientific evidence for: factors that influence body weight, optimal components of a weight loss and weight maintenance program, and the role of gender, age, and ethnicity in weight management.

Weighing the Options

Weighing the Options PDF

Author: Committee to Develop Criteria for Evaluating the Outcomes of Approaches to Prevent and Treat Obesity

Publisher: National Academies Press

Published: 1995-03-15

Total Pages: 297

ISBN-13: 030952136X

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Nearly one out of every three adults in America is obese and tens of millions of people in the United States are dieting at any one time. This has resulted in a weight-loss industry worth billions of dollars a year and growing. What are the long-term results of weight-loss programs? How can people sort through the many programs available and select one that is right for them? Weighing the Options strives to answer these questions. Despite widespread public concern about weight, few studies have examined the long-term results of weight-loss programs. One reason that evaluating obesity management is difficult is that no other treatment depends so much on an individual's own initiative and state of mind. Now, a distinguished group of experts assembled by the Institute of Medicine addresses this compelling issue. Weighing the Options presents criteria for evaluating treatment programs for obesity and explores what these criteria mean--to health care providers, program designers, researchers, and even overweight people seeking help. In presenting its criteria the authors offer a wealth of information about weight loss: how obesity is on the rise, what types of weight-loss programs are available, how to define obesity, how well we maintain weight loss, and what approaches and practices appear to be most successful. Information about weight-loss programs--their clients, staff qualifications, services, and success rates--necessary to make wise program choices is discussed in detail. The book examines how client demographics and characteristics--including health status, knowledge of weight-loss issues, and attitude toward weight and body image--affect which programs clients choose, how successful they are likely to be with their choices, and what this means for outcome measurement. Short- and long-term safety consequences of weight loss are discussed as well as clinical assessment of individual patients. The authors document the health risks of being overweight, summarizing data indicating that even a small weight loss reduces the risk of disease and depression and increases self-esteem. At the same time, weight loss has been associated with some poor outcomes, and the book discusses the implications for program evaluation. Prevention can be even more important than treatment. In Weighing the Options, programs for population groups, efforts targeted to specific groups at high risk for obesity, and prevention of further weight gain in obese individuals get special attention. This book provides detailed guidance on how the weight-loss industry can improve its programs to help people be more successful at long-term weight loss. And it provides consumers with tips on selecting a program that will improve their chances of permanently losing excess weight.

Are Rodent Models Fit for Investigation of Human Obesity and Related Diseases?

Are Rodent Models Fit for Investigation of Human Obesity and Related Diseases? PDF

Author: Patrick C. Even

Publisher: Frontiers Media SA

Published: 2018-02-15

Total Pages: 161

ISBN-13: 2889454258

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Not only developed countries, but also most developing areas of the world, have experienced a surge in obesity prevalence over recent decades. Obesity complications are now among the leading causes of premature mortality, encompassing conditions such as coronary heart disease, stroke, and type 2 diabetes. This places a heavy burden on contemporary healthcare systems. While rodent models have limitations as experimental models of human obesity-related disease, study of rats and mice either spontaneously prone - or resistant - to obesity, or genetically engineered to illuminate underlying mechanisms has yielded key information about the metabolic defects linked to obesity, and their associated diseases. This topic includes both original research studies and reviews of the use of animal studies in specific areas of obesity-related disease. Various methodological approaches are discussed, with evaluation of the extent to which use of animal models has facilitated progress, or, conversely, has proved a cul de sac in investigation of human disease mechanisms. Consideration is also given to future strategies to use such rodent models optimally to enhance comprehension and treatment of pandemic human obesity-related diseases.

The Genetics of Obesity

The Genetics of Obesity PDF

Author: Claude Bouchard

Publisher: CRC Press

Published: 1994-03-28

Total Pages: 262

ISBN-13: 9780849348808

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This book provides a comprehensive compilation of the evidence available regarding the role of genetic differences in the etiology of human obesities and their health and metabolic implications. It also identifies the most promising research areas, methods, and strategies for use in future efforts to understand the genetic basis of obesities and their consequences on human health. Leading researchers in their respective fields present contributed chapters on such topics as etiology and the prevalence of obesities, nongenetic determinants of obesity and fat topography, and animal models and molecular biological technology used to delineate the genetic basis of human obesities. A major portion of the book is devoted to human genetic research and clinical observations encompassing adoption studies, twin studies, family studies, single gene effects, temporal trends and etiology heterogeneity, energy intake and food preference, energy expenditure, and susceptibility to metabolic derangements in the obese state. Future directions of research in the field are covered in the book as well.

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease PDF

Author: Louise Thibault

Publisher: Elsevier Inc. Chapters

Published: 2013-05-29

Total Pages: 56

ISBN-13: 0128072032

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This chapter aims to review literature on different aspects of obesity from fat-rich diets in non-human species. Usefulness of using small rodents in animal models to infer aspects of human obesity is discussed in terms of similarities and differences and how obesity is defined. The paradigm of using fat-rich diets in animal models of human obesity is explored according to its adequacy and dietary characteristics related to fatty acid composition. Physiological factors and mechanisms that can play a role in the development of obesity induced by a diet rich in fat are examined, namely the efficiency of nutrient utilization and the possible lack of inhibitory effect of fat on intake. The role of hormones such as leptin, ghrelin and insulin is discussed. Bevavioural mechanisms related to sensory-specific facilitation of eating with fat rich diets, altered feeding rhythmicity and learned eating are considered. The possible reversal of fat-rich diet induced obesity in animal models is explored. This chapter concludes with comments on appropriate design of animal studies and suggestions for future research.

Leptin

Leptin PDF

Author: V. Daniel Castracane

Publisher: Springer Science & Business Media

Published: 2006-12-22

Total Pages: 375

ISBN-13: 0387314164

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This book is an edited collection of the literature on leptin beginning with the discovery of leptin and a study of its affect on animals and in humans. Chapters will focus on the discovery, history, roles and regulation of leptin in all the major areas of physiology, as well as on assay methods, phylogeny and genetics. The timing of this volume is long overdue and is the first comprehensive coverage of leptin physiology in the field.

Obesity and Overeating

Obesity and Overeating PDF

Author: Wiley

Publisher: John Wiley & Sons

Published: 2013-07-12

Total Pages: 194

ISBN-13: 1118734297

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With the increasing worldwide incidence of obesity and the resulting increase in metabolic disorders such as diabetes, cardiovascular diseases and some cancers, an understanding of the multitude of factors that contribute to obesity is crucial for researchers to develop more effective treatments. This collection of overviews and protocols provides the reader with an introduction to the major features of obesity research, including the interplay between energy balance, hormones and neurobiological networks. An overview is provided which describes the animal models of obesity most commonly utilized in research. A standardized laboratory protocol for producing diet?]induced obesity (DIO) in both mouse and rat is provided as are protocols that describe how diet formulation can be modified to generate mouse models of human metabolic pathologies. Protocols are also provided for testing the effects of dietary manipulations, caloric restriction and potential therapeutics. This e-book — a curated collection from eLS, WIREs, and Current Protocols — offers a fantastic introduction to the field of obesity research for students or interdisciplinary collaborators.