Modeling HIV Transmission and AIDS in the United States

Modeling HIV Transmission and AIDS in the United States PDF

Author: Herbert W. Hethcote

Publisher: Springer Science & Business Media

Published: 2013-03-09

Total Pages: 243

ISBN-13: 3642514774

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The disease that came to be called acquired immunodeficiency syndrome (AIDS) was first identified in the summer of 1981. By that time, nearly 100,000 persons in the United States may have been infected with human immunodeficiency virus (HIV). By the time the routes of transmission were clearly identified and HIV was established as the cause of AIDS in 1983, over 300,000 people may have been infected. That number has continued to increase, with approximately 1,000,000 Americans believed to be infected in 1991. The epidemic is of great public health concern because HlV is infectious, causes severe morbidity and death in most if not all of those infected, and often occurs in relatively young persons. In addition, the cost of medical care for a person with HIV disease is high, and the medical care needs of HIV-infected persons place a severe burden on the medical care systems in many areas. Understanding and controlling the HIV epidemic is a particularly difficult challenge. The long and variable period between HIV infection and clinical disease makes it difficult both to forecast the future magnitude of the epidemic, which is important for health care planning, and to estimate the number infected in the last several years, which is important for monitoring the current status of the epidemic.

Stochastic Modeling of AIDS Epidemiology and HIV Pathogenesis

Stochastic Modeling of AIDS Epidemiology and HIV Pathogenesis PDF

Author: Tan Wai-Yuan

Publisher: World Scientific Publishing Company

Published: 2000-09-29

Total Pages: 448

ISBN-13: 9813105623

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This book discusses systematically treatment on the development of stochastic, statistical and state space models of the HIV epidemic and of HIV pathogenesis in HIV-infected individuals, and presents the applications of these models. The book is unique in several ways: (1) it uses stochastic difference and differential equations to present the stochastic models of the HIV epidemic and HIV pathogenesis; in this sense, the deterministic models are considered as special cases when the numbers of different type of people or cells are very large; (2) it provides a critical analysis of deterministic and statistical models in the literature; (3) it develops state space models by combining stochastic models and statistical models; and (4) it provides a detailed discussion on the pros and cons of the different modeling approaches. This book is the first to introduce state space models for the HIV epidemic. It is also the first to develop stochastic models and state space models for the HIV pathogenesis in HIV-infected individuals.

HIV Transmission

HIV Transmission PDF

Author: D. M. Basavarajaiah

Publisher: Springer Nature

Published: 2019-11-29

Total Pages: 340

ISBN-13: 9811501513

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This book presents models describing HIV transmission rates at population level, discussing the main statistical methods and analytical interventions. It also assesses the practical applicability of the various modelling techniques, offering readers insights into what methods are available and, more importantly, when they should be used to address HIV transmission at global level. The book includes realistic simulation models fitted to clarify the rate of HIV mother-to-child transmission (HIV MTCT), and substantiates the conclusions that can be drawn as well as the appropriate time for making global-level clinical decisions concerning people living with HIV/AIDS (PLHIVs). Intended for students, academics and researchers, the book offers more than just an introduction to the topic – it also features in-depth, yet easy-to-understand, descriptions of a new mathematical/statistical HIV mother-to-child transmission model, making it a useful resource for clinicians, public health workers and policymakers involved in implementing HIV-prevention programmes at national /global level.

Deterministic and Stochastic Models of AIDS Epidemics and HIV Infections with Intervention

Deterministic and Stochastic Models of AIDS Epidemics and HIV Infections with Intervention PDF

Author: W. Y. Tan

Publisher: World Scientific

Published: 2005

Total Pages: 610

ISBN-13: 9812561390

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- Only book on extensive, deterministic models, statistic models, stochastic models and state space models and statistical methods for HIV epidemic involving IV drug usage and HIV epidemic in homosexual populations. - Provides most recent biological insights into HIV pathogenesis and HIV kinetics at the cellular level, and illustrates how to build up mathematical models based on these biological insights. - Only publication that provides in-depth analysis of HAART treatment protocols and discusses possible improvements to the HAART protocol. The book also provides connection between pharmacokinetics with treatment in HIV-infected individuals.

Mathematical and Statistical Approaches to AIDS Epidemiology

Mathematical and Statistical Approaches to AIDS Epidemiology PDF

Author: Carlos Castillo-Chavez

Publisher: Springer Science & Business Media

Published: 2013-03-13

Total Pages: 416

ISBN-13: 3642934544

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The 18 research articles of this volume discuss the major themes that have emerged from mathematical and statistical research in the epidemiology of HIV. The opening paper reviews important recent contributions. Five sections follow: Statistical Methodology and Forecasting, Infectivity and the HIV, Heterogeneity and HIV Transmission Dynamics, Social Dynamics and AIDS, and The Immune System and The HIV. In each, leading experts in AIDS epidemiology present the recent results. Some address the role of variable infectivity, heterogeneous mixing, and long periods of infectiousness in the dynamics of HIV; others concentrate on parameter estimation and short-term forecasting. The last section looks at the interaction between the HIV and the immune system.

The Social Impact of AIDS in the United States

The Social Impact of AIDS in the United States PDF

Author: Panel on Monitoring the Social Impact of the AIDS Epidemic

Publisher:

Published: 1993-01-15

Total Pages: 340

ISBN-13:

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Instead, as persons with AIDS and their loved ones can painfully testify, those infected with HIV know long in advance what will come. And the nation will confront AIDS and its consequences for years. AIDS in the United States also differs from other "democratic" epidemics in its concentration among gay men and intravenous drug users and their sexual partners, with many HIV-positive persons being among the nation's most poor and disadvantaged. The disease characteristics of AIDS have posed challenges to the way we have traditionally delivered health care. It is affecting the nature and structure of voluntarism, as volunteers step in to fill gaps left by decreases in public health funding. The political organization of the gay community has resulted in new policy directions for the use of medical test results, availability of experimental drugs, and other privacy and public health issues.

Modeling the AIDS Epidemic

Modeling the AIDS Epidemic PDF

Author: Margaret L. Brandeau

Publisher: Raven Press (ID)

Published: 1994

Total Pages: 664

ISBN-13:

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Emerging from the 34th Joint National Meeting of the Operations Research Society of America and The Institute of Management Sciences, held in San Francisco, November 1992, this volume presents AIDS modeling research that can directly or indirectly improve decision making for planning, resource allocation, and public health policy. The volume is divided into four sections: AIDS policy modeling; models for AIDS backcasting and forecasting; modeling infectivity and disease progression; and modeling the social organization of risky behavior. Annotation copyright by Book News, Inc., Portland, OR

Understanding the HIV/AIDS Epidemic in the United States

Understanding the HIV/AIDS Epidemic in the United States PDF

Author: Eric R. Wright

Publisher: Springer

Published: 2016-07-30

Total Pages: 302

ISBN-13: 3319340042

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This book examines the HIV/AIDS epidemic in the United States using the concept of syndemics to contextualize the risk of both well-known, and a few lesser-known, subpopulations that experience disproportionately high rates of HIV and/or AIDS within the United States. Since discovery, HIV/AIDS has exposed a number of social, psychological, and biological aspects of disease transmission. The concept of “syndemics,” or “synergistically interacting epidemics” has emerged as a powerful framework for understanding both the epidemiological patterns and the myriad of problems associated with HIV/AIDS around the world and within the United States. The book considers the disparities in HIV/AIDS in relation to social aspects, risk behavior and critical illness comorbidities. It updates and enhances our understanding of the HIV/AIDS epidemic in the United States and contributes to the expanding literature on the role of syndemics in shaping the public’s health.​

Handbook on Immunosenescence

Handbook on Immunosenescence PDF

Author: Tamas Fulop

Publisher: Springer Science & Business Media

Published: 2009-02-27

Total Pages: 1693

ISBN-13: 1402090633

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This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.