Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants

Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants PDF

Author: Yvonne Will

Publisher: John Wiley & Sons

Published: 2018-03-23

Total Pages: 816

ISBN-13: 1119329744

DOWNLOAD EBOOK →

Developed as a one-stop reference source for drug safety and toxicology professionals, this book explains why mitochondrial failure is a crucial step in drug toxicity and how it can be avoided. • Covers both basic science and applied technology / methods • Allows readers to understand the basis of mitochondrial function, the preclinical assessments used, and what they reveal about drug effects • Contains both in vitro and in vivo methods for analysis, including practical screening approaches for drug discovery and development • Adds coverage about mitochondrial toxicity underlying organ injury, clinical reports on drug classes, and discussion of environmental toxicants affecting mitochondria

Mitochondrial Dysfunction

Mitochondrial Dysfunction PDF

Author: Lawrence H. Lash

Publisher: Elsevier

Published: 2013-10-22

Total Pages: 527

ISBN-13: 1483218619

DOWNLOAD EBOOK →

Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.

Drug-Induced Mitochondrial Dysfunction

Drug-Induced Mitochondrial Dysfunction PDF

Author: James A. Dykens

Publisher: Wiley-Interscience

Published: 2008-09-22

Total Pages: 0

ISBN-13: 9780470111314

DOWNLOAD EBOOK →

This is the definitive, one-stop resource on preclinical drug evaluation for potential mitochondrial toxicity, addressing the issue upfront in the drug development process. It discusses mitochondrial impairment to organs, skeletal muscle, and nervous systems and details methodologies used to assess mitochondria function. It covers both in vitro and in vivo methods for analysis and includes the latest models. This is the authoritative reference on drug-induced mitochondrial dysfunction for safety assessment professionals in the pharmaceutical industry and for pharmacologists and toxicologists in both drug and environmental health sciences.

Drug-Induced Mitochondrial Dysfunction

Drug-Induced Mitochondrial Dysfunction PDF

Author: James A. Dykens

Publisher: John Wiley & Sons

Published: 2008-09-11

Total Pages: 648

ISBN-13: 0470372524

DOWNLOAD EBOOK →

This is the definitive, one-stop resource on preclinical drug evaluation for potential mitochondrial toxicity, addressing the issue upfront in the drug development process. It discusses mitochondrial impairment to organs, skeletal muscle, and nervous systems and details methodologies used to assess mitochondria function. It covers both in vitro and in vivo methods for analysis and includes the latest models. This is the authoritative reference on drug-induced mitochondrial dysfunction for safety assessment professionals in the pharmaceutical industry and for pharmacologists and toxicologists in both drug and environmental health sciences.

Mitochondrial Metabolism

Mitochondrial Metabolism PDF

Author: Jalal Pourahmad

Publisher: Academic Press

Published: 2021-07-28

Total Pages: 316

ISBN-13: 0128224096

DOWNLOAD EBOOK →

Mitochondrial Metabolism: An Approach for Disease Management covers mitotherapy from three combined perspectives, Pharmacology, Toxicology and Biochemistry. After an introduction from world-renowned experts, the book's chapters cover the balancing role in reduction/oxidation mitochondria play, mitochondria as targets for therapeutics through its metabolism, mitochondrial contributions to the cell death process, mitochondrial response to environmental toxicants, the mitochondrial role in aging, the impact of calorie restrictive diets, new advances in the identification of altered mitochondria associated signaling pathways in carcinogenesis, and much more. This book provides bioscientists new horizons to realize the importance of mitochondria in present-day research on therapies dealing with mitochondria associated chronic diseases, including diabetes, cancer and neurodegenerative disorders. Details the significant role of mitochondria in chronic diseases Presents new insights on the targeting of mitochondria for therapeutic purposes Includes updated results on mitotherapy and other mitochondria-oriented therapies

Drug-Induced Liver Injury

Drug-Induced Liver Injury PDF

Author:

Publisher: Academic Press

Published: 2019-07-13

Total Pages: 288

ISBN-13: 0128173173

DOWNLOAD EBOOK →

Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

Drug Discovery Toxicology

Drug Discovery Toxicology PDF

Author: Yvonne Will

Publisher: John Wiley & Sons

Published: 2016-03-22

Total Pages: 899

ISBN-13: 1119053390

DOWNLOAD EBOOK →

As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods • Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices

Toxicology Studies

Toxicology Studies PDF

Author: Ana Cristina Andreazza

Publisher: BoD – Books on Demand

Published: 2015-07-08

Total Pages: 246

ISBN-13: 9535121405

DOWNLOAD EBOOK →

The increased exposure to toxins, toxicants and novel drugs has promoted toxicology to become one of the most important areas of research with emerging innovative toxicity testing protocols, techniques, and regulation being placed. Since the bioactivation of many toxins and toxicants and its consequences on human health are not clearly known, this book offers a quick overview of cellular toxicology through the cell, drug and environmental toxicity. This book does not strive to be comprehensive but instead offers a quick overview of principle aspects of toxins and toxicants in order to familiarize the key principles of toxicology. The book is divided into three main sections,; the first one discusses the role of mitochondrial dysfunction, oxidative stress and mitochondrial drug development. The second and third sections bring light to forensic toxicology and drug poisoning followed by environmental toxicity.

Clinical Environmental Medicine - E-BOOK

Clinical Environmental Medicine - E-BOOK PDF

Author: Walter J. Crinnion

Publisher: Elsevier Health Sciences

Published: 2018-04-26

Total Pages: 520

ISBN-13: 0323480853

DOWNLOAD EBOOK →

Did you know that high levels of toxins in the human body can be linked to common conditions such as infertility, obesity, rheumatoid arthritis, heart disease, and diabetes? With therapeutic guidance designed for clinicians, Clinical Environmental Medicine focuses on how toxins such as arsenic, lead, mercury and organophosphates have become one of the leading causes of chronic disease in the industrial world. The first edition of this text describes how to treat these undesirable elements and molecules that can poison enzyme systems, damage DNA, increase inflammation and oxidative stress, and damage cell membranes. Expert authors Walter Crinnion and Joseph E. Pizzorno offer practical guidance for assessing both total body load as well as specific toxins. In addition, evidence-based treatment procedures provide recommendations for decreasing toxin exposure and supporting the body’s biotransformation and excretion processes. NEW! Unique! Practical diagnostic and therapeutic guidance designed for clinicians. NEW! Unique! Coverage of the most common diseases for which toxins are a primary cause. NEW! Description of how each toxin causes damage provides insights into sources, body load, and interventions for each toxin. NEW! Unique! Entirely evidence-based content focuses on the most common conditions from which patients suffer. NEW! Unique! Coverage of environmental toxicants, endogenous toxicants, and "toxins of choice" focuses on non-industrially-exposed populations.

Lanterna Rally - Theme by Grace Themes