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MicroRNAs in Diseases and Disorders

Author: Philip V Peplow

Publisher: Royal Society of Chemistry

Published: 2019-05-07

Total Pages: 500

ISBN-13: 1788017811

From pathology to treatment, MicroRNAs in Diseases and Disorders highlights the role of microRNAs (miRNAs) in the development and progression of a variety of diseases, including cancer, neurological disease, endocrine disease and autoimmune disease, and underscores the utilization of miRNA targets in the treatment of these conditions. Providing a comprehensive account, this book also includes the identification of miRNAs as diagnostic and prognostic biomarkers for disease, as well as evaluates translational value from clinical trials using synthesized and functionalized miRNA mimics and inhibitors. With a global contribution list and chapters from leading experts across the field, MicroRNAs in Diseases and Disorders is an invaluable reference to miRNA researchers and health professionals in a variety of disease areas in government, academia and industry. The book will also appeal to pharmaceutical and medicinal chemists with an interest in miRNA targeting therapeutics, as well as to advanced students in chemical biology and drug discovery.

MicroRNAs in Diseases and Disorders: Emerging Therapeutic Targets

Author: Philip V Peplow

Publisher: Royal Society of Chemistry

Published: 2019-05-21

Total Pages: 500

ISBN-13: 1788013948

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MicroRNA

Author: Jaishree Paul

Publisher: CRC Press

Published: 2018-02-19

Total Pages: 231

ISBN-13: 1351679872

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This book explores the role of miRNA as therapeutic agents, the progress made in this direction and the problems that need to be addressed for miRNA based therapies to become successful. It also discusses the basic biology of miRNA sythesis, regulation, and their role in disease biology.

Hormones, Metabolism and the Benefits of Exercise

Author: Bruce Spiegelman

Publisher: Springer

Published: 2018-03-07

Total Pages: 108

ISBN-13: 3319727907

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The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism. This will include novel “myokines” that might act as new therapeutic agents in the future.

Current Perspectives in microRNAs (miRNA)

Author: Shao-Yao Ying

Publisher: Springer Science & Business Media

Published: 2008-09-12

Total Pages: 461

ISBN-13: 1402085338

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Nearly 97% of the human genome is the non-coding DNA, which varies from one species to another, and changes in these sequences are frequently noticed to manifest clinical and circumstantial malfunction. Numerous non-protein-coding genes are recently found to encode microRNAs, which are responsible for RNA-mediated gene silencing through RNA interference (RNAi)-like pathways. MicroRNAs (miRNAs), small single-stranded 17–25 nucleotide RNAs capable of interfering with intracellular messenger RNAs (mRNAs) that contain either complete or partial complementarity, are useful for the design of new therapies against cancer polymorphism and viral mutation. Currently over 1000 native miRNA species found in vertebrates and many more new miRNA homologs continue to be identified; however, most of their functions remain to be determined. In this book, many new perspectives of the miRNA research are reviewed and discussed, including their roles in stem cell maintenance, embryonic development, tissue differentiation, adult physiology, disease pathology, cancer research, viral infection, genetic engineering in plants, and utility in cosmetic applications. These new findings may not only provide significant insight into the various mechanisms of miRNAs but also offer a great opportunity in developing new therapeutic interventions.

MicroRNA

Author: Jaishree Paul

Publisher: CRC Press

Published: 2018

Total Pages: 202

ISBN-13: 9781138054837

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"A CRC title, part of the Taylor & Francis imprint, a member of the Taylor & Francis Group, the academic division of T&F Informa plc."

MicroRNAs in Medicine

Author: Charles H. Lawrie

Publisher: John Wiley & Sons

Published: 2013-10-30

Total Pages: 702

ISBN-13: 1118300343

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MicroRNAs in Medicine provides an access point into the current literature on microRNA for both scientists and clinicians, with an up-to-date look at what is happening in the emerging field of microRNAs and their relevance to medicine. Each chapter is a comprehensive review, with descriptions of the latest microRNA research written by international leaders in their field. Opening with an introduction to what microRNAs are and how they function, the book goes on to explore the role of microRNAs in normal physiological functions, infectious diseases, non-infectious diseases, cancer, circulating microRNAs as non-invasive biomarkers, and finally their potential as novel therapeutics. Including background information on the field as well as reviews of the latest research breakthroughs, MicroRNAs in Medicine is a one-stop source of information to satisfy the specialists and non-specialists alike, appealing to students, researchers, and clinicians interested in understanding the potential of microRNAs in medicine and research.

MiRNomics

Author: Malik Yousef

Publisher:

Published: 2014

Total Pages: 333

ISBN-13: 9781627037488

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In miRNomics: MicroRNA Biology and Computational Analysis, expert researchers in the field present an overview of the current state of the art and aim to put the respective areas of research into a larger perspective. These include methods and techniques ranging from miRNA biogenesis, their biological function, computational analyses to their medical implications and applications. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, miRNomics: MicroRNA Biology and Computational Analysis seeks to aid scientists in the further study into miRNA research and statistics.

Antisense Therapy

Author: Shashwat Sharad

Publisher: BoD – Books on Demand

Published: 2019-11-20

Total Pages: 126

ISBN-13: 1789845327

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Antisense Therapy offers a comprehensive, state-of-the art perspective on the role of antisense therapy in the treatment of human disease, with a special focus on cancer. Use of antisense oligonucleotides is a growing field of pharmaceutical and biotech companies and research programs for treatment of several diseases. This book summarizes and presents the best updates, therapeutic principles, methods, and applications in the field and offers meaningful information to move treatment discovery forward.

MicroRNA in Human Infectious Diseases

Author: Vijay Kumar Prajapati

Publisher: Elsevier

Published: 2024-01-23

Total Pages: 346

ISBN-13: 0323996620

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MicroRNA in Human Infectious Diseases offers a detailed overview of the therapeutic and diagnostic role microRNAs can play in the treatment of various infectious diseases. Beginning with an introduction on microRNAs and their mechanisms, the book then delves into the therapeutic role of microRNAs in various categories of diseases: bacterial, viral, and parasitic. A wide range of diseases are explored in these sections, including sexually transmitted diseases, typhoid, tuberculosis, Dengue fever, Ebola, Covid-19, Malaria, Leishmaniasis, and Lymphatic filariasis. The final section of the book covers microRNA-based system approaches, considering aspects such as web-based tools available for detecting and predicting microRNA targets, and the latest technologies for modifying and manipulating microRNAs. This volume explores microRNA across a multitude of conditions and is an ideal reference for those involved in the investigation and development of treatments in this area. Includes foundational knowledge on microRNAs and the fundamental aspects of its biogenesis Explores the potential role microRNAs can play in therapeutics and diagnostics to treat various infectious diseases, including sexually-transmitted diseases, bacterial diseases, viral infections, and parasitic diseases Features a chapter dedicated to the role of microRNA for therapeutics in respiratory viral infections, such as Covid-19 Considers technologies used for manipulating and modifying microRNAs in preparation for applications to treat infectious diseases