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Author: Valentim R. Alferes
Publisher: SAGE
Published: 2012-10
Total Pages: 209
ISBN-13: 1452202923
DOWNLOAD EBOOK →This text provides a conceptual systematization and a practical tool for the randomization of between-subjects and within-subjects experimental designs.
Author: Valentim R. Alferes
Publisher: SAGE Publications
Published: 2012-10-01
Total Pages: 209
ISBN-13: 1483303527
DOWNLOAD EBOOK →In Methods of Randomization in Experimental Design, author Valentim R. Alferes presents the main procedures of random assignment and local control in between-subjects experimental designs and the counterbalancing schemes in within-subjects or cross-over experimental designs. Alferes uses a pedagogical strategy that allows the reader to implement all randomization methods by relying on the materials given in the appendices and using common features included in most word processor software. A companion website at www.sagepub.com/alferes provides downloadable IBM SPSS and R versions of SCRAED, a package that performs simple and complex random assignment in experimental design, including the 18 randomization methods presented in Chapters 2 and 3.
Author: William F. Rosenberger
Publisher: John Wiley & Sons
Published: 2015-11-23
Total Pages: 284
ISBN-13: 1118742249
DOWNLOAD EBOOK →Praise for the First Edition “All medical statisticians involved in clinical trials should read this book…” - Controlled Clinical Trials Featuring a unique combination of the applied aspects of randomization in clinical trials with a nonparametric approach to inference, Randomization in Clinical Trials: Theory and Practice, Second Edition is the go-to guide for biostatisticians and pharmaceutical industry statisticians. Randomization in Clinical Trials: Theory and Practice, Second Edition features: Discussions on current philosophies, controversies, and new developments in the increasingly important role of randomization techniques in clinical trials A new chapter on covariate-adaptive randomization, including minimization techniques and inference New developments in restricted randomization and an increased focus on computation of randomization tests as opposed to the asymptotic theory of randomization tests Plenty of problem sets, theoretical exercises, and short computer simulations using SAS® to facilitate classroom teaching, simplify the mathematics, and ease readers’ understanding Randomization in Clinical Trials: Theory and Practice, Second Edition is an excellent reference for researchers as well as applied statisticians and biostatisticians. The Second Edition is also an ideal textbook for upper-undergraduate and graduate-level courses in biostatistics and applied statistics. William F. Rosenberger, PhD, is University Professor and Chairman of the Department of Statistics at George Mason University. He is a Fellow of the American Statistical Association and the Institute of Mathematical Statistics, and author of over 80 refereed journal articles, as well as The Theory of Response-Adaptive Randomization in Clinical Trials, also published by Wiley. John M. Lachin, ScD, is Research Professor in the Department of Epidemiology and Biostatistics as well as in the Department of Statistics at The George Washington University. A Fellow of the American Statistical Association and the Society for Clinical Trials, Dr. Lachin is actively involved in coordinating center activities for clinical trials of diabetes. He is the author of Biostatistical Methods: The Assessment of Relative Risks, Second Edition, also published by Wiley.
Author: Anton Bespalov
Publisher: Springer Nature
Published: 2020-01-01
Total Pages: 424
ISBN-13: 3030336565
DOWNLOAD EBOOK →This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine.
Author: Peter G. Smith
Publisher: Oxford University Press, USA
Published: 2015
Total Pages: 479
ISBN-13: 0198732864
DOWNLOAD EBOOK →"IEA, International Epidemiological Association, Welcome Trust."
Author: Institute of Medicine
Publisher: National Academies Press
Published: 2001-01-01
Total Pages: 221
ISBN-13: 0309171148
DOWNLOAD EBOOK →Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.
Author: Neil J. Salkind
Publisher: SAGE
Published: 2010-06-22
Total Pages: 1779
ISBN-13: 1412961270
DOWNLOAD EBOOK →"Comprising more than 500 entries, the Encyclopedia of Research Design explains how to make decisions about research design, undertake research projects in an ethical manner, interpret and draw valid inferences from data, and evaluate experiment design strategies and results. Two additional features carry this encyclopedia far above other works in the field: bibliographic entries devoted to significant articles in the history of research design and reviews of contemporary tools, such as software and statistical procedures, used to analyze results. It covers the spectrum of research design strategies, from material presented in introductory classes to topics necessary in graduate research; it addresses cross- and multidisciplinary research needs, with many examples drawn from the social and behavioral sciences, neurosciences, and biomedical and life sciences; it provides summaries of advantages and disadvantages of often-used strategies; and it uses hundreds of sample tables, figures, and equations based on real-life cases."--Publisher's description.
Author: Simon T. Bate
Publisher: Cambridge University Press
Published: 2014-03-13
Total Pages: 327
ISBN-13: 1107030781
DOWNLOAD EBOOK →This book will provide scientists with a better understanding of statistics, improving their decision-making and reducing animal use.
Author: John B. Todman
Publisher: Psychology Press
Published: 2001-03
Total Pages: 231
ISBN-13: 1135659354
DOWNLOAD EBOOK →This book is a practical guide to help researchers draw valid causal inferences from small-scale clinical intervention studies. It should be of interest to teachers of, and students in, courses with an experimental clinical component, as well as clinical researchers. Inferential statistics used in the analysis of group data are frequently invalid for use with data from single-case experimental designs. Even non-parametric rank tests provide, at best, approximate solutions for only some single-case (and small-n ) designs. Randomization (Exact) tests, on the other hand, can provide valid statistical analyses for all designs that incorporate a random procedure for assigning treatments to subjects or observation periods, including single-case designs. These Randomization tests require large numbers of data rearrangements and have been seldom used, partly because desktop computers have only recently become powerful enough to complete the analyses in a reasonable time. Now that the necessary computational power is available, they continue to be under-used because they receive scant attention in standard statistical texts for behavioral researchers and because available programs for running the analyses are relatively inaccessible to researchers with limited statistical or computing interest. This book is first and foremost a practical guide, although it also presents the theoretical basis for Randomization tests. Its most important aim is to make these tests accessible to researchers for a wide range of designs. It does this by providing programs on CD-ROM that allow users to run analyses of their data within a standard package (Minitab, Excel, or SPSS) with which they are already familiar. No statistical or computing expertise is required to use these programs. This is the "new stats" for single-case and small-n intervention studies, and anyone interested in this research approach will benefit.
Author: Valentim R. Alferes
Publisher:
Published: 2012
Total Pages: 183
ISBN-13: 9781452270012
DOWNLOAD EBOOK →This text provides a conceptual systematization and a practical tool for the randomization of between-subjects and within-subjects experimental designs.
