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Continuous Discovery Habits

Author: Teresa Torres

Publisher: Product Talk LLC

Published: 2021-05-19

Total Pages: 201

ISBN-13: 1736633317

"If you haven't had the good fortune to be coached by a strong leader or product coach, this book can help fill that gap and set you on the path to success." - Marty Cagan How do you know that you are making a product or service that your customers want? How do you ensure that you are improving it over time? How do you guarantee that your team is creating value for your customers in a way that creates value for your business? In this book, you'll learn a structured and sustainable approach to continuous discovery that will help you answer each of these questions, giving you the confidence to act while also preparing you to be wrong. You'll learn to balance action with doubt so that you can get started without being blindsided by what you don't get right. If you want to discover products that customers love-that also deliver business results-this book is for you.

Models of Discovery

Author: Herbert A. Simon

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 471

ISBN-13: 9401095213

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We respect Herbert A. Simon as an established leader of empirical and logical analysis in the human sciences while we happily think of him as also the loner; of course he works with many colleagues but none can match him. He has been writing fruitfully and steadily for four decades in many fields, among them psychology, logic, decision theory, economics, computer science, management, production engineering, information and control theory, operations research, confirmation theory, and we must have omitted several. With all of them, he is at once the technical scientist and the philosophical critic and analyst. When writing of decisions and actions, he is at the interface of philosophy of science, decision theory, philosophy of the specific social sciences, and inventory theory (itself, for him, at the interface of economic theory, production engineering and information theory). When writing on causality, he is at the interface of methodology, metaphysics, logic and philosophy of physics, systems theory, and so on. Not that the interdisciplinary is his orthodoxy; we are delighted that he has chosen to include in this book both his early and little-appreciated treatment of straightforward philosophy of physics - the axioms of Newtonian mechanics, and also his fine papers on pure confirmation theory.

Drug Discovery Strategies and Methods

Author: Alexandros Makriyannis

Publisher: CRC Press

Published: 2003-11-04

Total Pages: 317

ISBN-13: 082475767X

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Navigate the complex and multidisciplinary path of drug discovery procedures with Drug Discovery Strategies and Methods-a well-organized and timely reference that analyzes methods in target identification and validation, lead detection, compound optimization, and biological testing. This volume addresses challenges encountered during the discovery of new pharmaceutical candidates including the use of cutting-edge techniques utilized in drug design and development. It considers key elements in the drug design cycle ranging from appropriateness of targets and disease models to compound characterization, safety, and efficacy and the role of protein crystallography in structure-based drug design.

Chance Discovery

Author: Yukio Ohsawa

Publisher: Springer Science & Business Media

Published: 2013-03-09

Total Pages: 420

ISBN-13: 3662062305

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Chance discovery means discovering chances - the breaking points in systems, the marketing windows in business, etc. It involves determining the significance of some piece of information about an event and then using this new knowledge in decision making. The techniques developed combine data mining methods for finding rare but important events with knowledge management, groupware, and social psychology. The reader will find many applications, such as finding information on the Internet, recognizing changes in customer behavior, detecting the first signs of an imminent earthquake, etc. This first book dedicated to chance discovery covers the state of the art in the theory and methods and examines typical scenarios, and it thus appeals to researchers working on new techniques and algorithms and also to professionals dealing with real-world applications.

Screening

Author: Angela Dean

Publisher: Springer Science & Business Media

Published: 2006-07-28

Total Pages: 347

ISBN-13: 0387280146

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The process of discovery in science and technology may require investigation of a large number of features, such as factors, genes or molecules. In Screening, statistically designed experiments and analyses of the resulting data sets are used to identify efficiently the few features that determine key properties of the system under study. This book brings together accounts by leading international experts that are essential reading for those working in fields such as industrial quality improvement, engineering research and development, genetic and medical screening, drug discovery, and computer simulation of manufacturing systems or economic models. Our aim is to promote cross-fertilization of ideas and methods through detailed explanations, a variety of examples and extensive references. Topics cover both physical and computer simulated experiments. They include screening methods for detecting factors that affect the value of a response or its variability, and for choosing between various different response models. Screening for disease in blood samples, for genes linked to a disease and for new compounds in the search for effective drugs are also described. Statistical techniques include Bayesian and frequentist methods of data analysis, algorithmic methods for both the design and analysis of experiments, and the construction of fractional factorial designs and orthogonal arrays. The material is accessible to graduate and research statisticians, and to engineers and chemists with a working knowledge of statistical ideas and techniques. It will be of interest to practitioners and researchers who wish to learn about useful methodologies from within their own area as well as methodologies that can be translated from one area to another.

Synthetic Methods in Drug Discovery

Author: David C. Blakemore

Publisher: Royal Society of Chemistry

Published: 2016

Total Pages: 474

ISBN-13: 1849738033

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The number of available synthetic methods can be overwhelming. In order to create novel motifs and templates which confer new and potentially valuable drug-like properties, it is important to know which synthetic methodologies will give the best results. Similarly, which methodologies are used to progress potential drug candidates from leads through the development process? What are the current industrial research problems and how can they be resolved in an industrial setting? This book highlights key methods that have real impact in drug discovery and facilitate delivery of drug molecules. Synthetic Methods in Drug Discovery Volume 1 focuses on the hugely important area of transition metal mediated methods used in industry. Current methods of importance such as the Suzuki-Miyaura coupling, Buchwald-Hartwig couplings and CH activation are discussed. In addition, exciting emerging areas such as decarboxylative coupling, and the uses of iron and nickel in coupling reactions are also covered. This book provides both academic and industrial perspectives on some key reactions giving the reader an excellent overview of the techniques used in modern synthesis. Reaction types are conveniently framed in the context of their value to industry and the challenges and limitations of methodologies are discussed with relevant illustrative examples. Edited and authored by leading scientists from both academia and industry, this book will be a valuable reference for all chemists involved in drug discovery as well as postgraduate students in medicinal chemistry.

Model Rules of Professional Conduct

Author: American Bar Association. House of Delegates

Publisher: American Bar Association

Published: 2007

Total Pages: 216

ISBN-13: 9781590318737

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The Model Rules of Professional Conduct provides an up-to-date resource for information on legal ethics. Federal, state and local courts in all jurisdictions look to the Rules for guidance in solving lawyer malpractice cases, disciplinary actions, disqualification issues, sanctions questions and much more. In this volume, black-letter Rules of Professional Conduct are followed by numbered Comments that explain each Rule's purpose and provide suggestions for its practical application. The Rules will help you identify proper conduct in a variety of given situations, review those instances where discretionary action is possible, and define the nature of the relationship between you and your clients, colleagues and the courts.

Data Mining Methods for Knowledge Discovery

Author: Krzysztof J. Cios

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 508

ISBN-13: 1461555892

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Data Mining Methods for Knowledge Discovery provides an introduction to the data mining methods that are frequently used in the process of knowledge discovery. This book first elaborates on the fundamentals of each of the data mining methods: rough sets, Bayesian analysis, fuzzy sets, genetic algorithms, machine learning, neural networks, and preprocessing techniques. The book then goes on to thoroughly discuss these methods in the setting of the overall process of knowledge discovery. Numerous illustrative examples and experimental findings are also included. Each chapter comes with an extensive bibliography. Data Mining Methods for Knowledge Discovery is intended for senior undergraduate and graduate students, as well as a broad audience of professionals in computer and information sciences, medical informatics, and business information systems.

Modern Methods of Drug Discovery

Author: Alexander Hillisch

Publisher: Birkhäuser

Published: 2012-11-28

Total Pages: 294

ISBN-13: 3034879970

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Research in the pharmaceutical industry today is in many respects quite different from what it used to be only fifteen years ago. There have been dramatic changes in approaches for identifying new chemical entities with a desired biological activity. While chemical modification of existing leads was the most important approach in the 1970s and 1980s, high-throughput screening and structure-based design are now major players among a multitude of methods used in drug discov ery. Quite often, companies favor one of these relatively new approaches over the other, e.g., screening over rational design, or vice versa, but we believe that an intelligent and concerted use of several or all methods currently available to drug discovery will be more successful in the medium term. What has changed most significantly in the past few years is the time available for identifying new chemical entities. Because of the high costs of drug discovery projects, pressure for maximum success in the shortest possible time is higher than ever. In addition, the multidisciplinary character of the field is much more pronounced today than it used to be. As a consequence, researchers and project managers in the pharmaceutical industry should have a solid knowledge of the more important methods available to drug discovery, because it is the rapidly and intelligently combined use of these which will determine the success or failure of preclinical projects.