Methodological Issues and Strategies in Clinical Research

Methodological Issues and Strategies in Clinical Research PDF

Author: Alan E. Kazdin

Publisher: Amer Psychological Assn

Published: 2002-11-15

Total Pages: 913

ISBN-13: 9781557989598

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The third edition of this resource is intended to assist students and professionals in increasing their mastery of the range of methodological approaches available with which to examine clinical issues and phenomena. Contributors explore experimental design; the principles, procedures and practices that govern research; assessment of study constructs and their interrelationships; potential sources of artifact and bias; methods of data analysis and interpretation; ethical issues; and publication and communication of research findings. With 19 new articles and significantly revised and expanded introductory material, this edition features many scholarly contributions that explicate core concepts, survey contemporary issues, and elaborate on ethical responsibilities. Additions include articles on mediators and moderators of effects, on methods for studying the efficacy and effectiveness of psychotherapy, and on ways of incorporating systematic observation and evaluation into clinical practice to improve patient care.

Methodological Issues & Strategies in Clinical Research

Methodological Issues & Strategies in Clinical Research PDF

Author: Alan E. Kazdin

Publisher:

Published: 2009

Total Pages: 765

ISBN-13:

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This book provides readings designed to improve understanding of methodology and to enhance research practices in clinical psychology. The intended audience is persons who are in training or are actively involved in research. The primary focus of the readings is clinical psychology, but the issues and methods are relevant to other areas as well, such as counseling, educational and school psychology, psychiatry, and social work. /// Several readings have been included to address a broad range of practices, procedures, and strategies for developing a sound knowledge base. The goal was to select, from a large literature on methodology and design, a special set of engaging articles of use to students and professionals alike. The articles address a wide range of topics within clinical research. /// The content of this book addresses experimental design, principles, procedures, and practices that govern research, assessment, sources of artifact and bias, data analyses and interpretation, ethical issues, and publication and communication of the results of research. (PsycINFO Database Record (c) 2004 APA, all rights reserved).

Fundamentals of Clinical Research

Fundamentals of Clinical Research PDF

Author: Antonella Bacchieri

Publisher: Springer Science & Business Media

Published: 2007-04-29

Total Pages: 367

ISBN-13: 8847004926

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Here is a new book on methods and issues in clinical research. Its objectives can be summarized in three points. 1. Integrate medical and statistical components of clinical research. 2. Do justice to the operational and practical requirements of clinical research. 3. Give space to the ethical implications of methodological issues in clinical research. The book ends with a brief description of the drug development process and the phases of clinical development.

Principles of Research Methodology

Principles of Research Methodology PDF

Author: Phyllis G. Supino

Publisher: Springer Science & Business Media

Published: 2012-06-22

Total Pages: 286

ISBN-13: 1461433606

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Principles of Research Methodology: A Guide for Clinical Investigators is the definitive, comprehensive guide to understanding and performing clinical research. Designed for medical students, physicians, basic scientists involved in translational research, and other health professionals, this indispensable reference also addresses the unique challenges and demands of clinical research and offers clear guidance in becoming a more successful member of a medical research team and critical reader of the medical research literature. The book covers the entire research process, beginning with the conception of the research problem to publication of findings. Principles of Research Methodology: A Guide for Clinical Investigators comprehensively and concisely presents concepts in a manner that is relevant and engaging to read. The text combines theory and practical application to familiarize the reader with the logic of research design and hypothesis construction, the importance of research planning, the ethical basis of human subjects research, the basics of writing a clinical research protocol and scientific paper, the logic and techniques of data generation and management, and the fundamentals and implications of various sampling techniques and alternative statistical methodologies. Organized in thirteen easy to read chapters, the text emphasizes the importance of clearly-defined research questions and well-constructed hypothesis (reinforced throughout the various chapters) for informing methods and in guiding data interpretation. Written by prominent medical scientists and methodologists who have extensive personal experience in biomedical investigation and in teaching key aspects of research methodology to medical students, physicians and other health professionals, the authors expertly integrate theory with examples and employ language that is clear and useful for a general medical audience. A major contribution to the methodology literature, Principles of Research Methodology: A Guide for Clinical Investigators is an authoritative resource for all individuals who perform research, plan to perform it, or wish to understand it better.

Small Clinical Trials

Small Clinical Trials PDF

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2001-01-01

Total Pages: 221

ISBN-13: 0309171148

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Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.

Clinical Trials

Clinical Trials PDF

Author: Duolao Wang

Publisher: Remedica

Published: 2006

Total Pages: 497

ISBN-13: 1901346722

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This book explains statistics specifically for a medically literate audience. Readers gain not only an understanding of the basics of medical statistics, but also a critical insight into how to review and evaluate clinical trial evidence.

Human Experimentation

Human Experimentation PDF

Author: Ton J. Cleophas

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 116

ISBN-13: 9401146632

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Despite their effectiveness in the evaluation of new pharmacological compounds, controlled clinical trials are sometimes inadequate. Using data from the literature as well as from the author's own experience with clinical trials, Human Experimentation: Methodologic Issues Fundamental to Clinical Trials addresses such inadequacies and tries to provide solutions. This work is the first to thoroughly examine these unsolved inadequacies and problems with the design and the execution of clinical trials and, more importantly, to provide solutions for these problems. It is important for anyone who is involved in clinical research: clinicians, pharmacists, biochemists, statisticians, nurses, sponsors, etc., and anyone who is involved in applying results of research to patients, i.e. physicians.

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