Melanopsin Vision

Melanopsin Vision PDF

Author: Daniel S. Joyce

Publisher: Cambridge University Press

Published: 2023-01-31

Total Pages: 75

ISBN-13: 1009034219

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Intrinsically photosensitive retinal ganglion cells (ipRGGs) are the most recently discovered photoreceptor class in the human retina. This Element integrates new knowledge and perspectives from visual neuroscience, psychology, sleep science and architecture to discuss how melanopsin-mediated ipRGC functions can be measured and their circuits manipulated. It reveals contemporary and emerging lighting technologies as powerful tools to set mind, brain and behaviour.

Melanopsin Vision

Melanopsin Vision PDF

Author: Daniel S. Joyce

Publisher: Elements in Perception

Published: 2023-01-19

Total Pages: 75

ISBN-13: 1009014870

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This Element provides an integrative approach to understanding light sensation in humans.

Retinal Development

Retinal Development PDF

Author: Evelyne Sernagor

Publisher: Cambridge University Press

Published: 2012-11-29

Total Pages: 369

ISBN-13: 1139459732

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This advanced text, first published in 2006, takes a developmental approach to the presentation of our understanding of how vertebrates construct a retina. Written by experts in the field, each of the seventeen chapters covers a specific step in the process, focusing on the underlying molecular, cellular, and physiological mechanisms. There is also a special section on emerging technologies, including genomics, zebrafish genetics, and stem cell biology that are starting to yield important insights into retinal development. Primarily aimed at professionals, both biologists and clinicians working with the retina, this book provides a concise view of vertebrate retinal development. Since the retina is 'an approachable part of the brain', this book will also be attractive to all neuroscientists interested in development, as processes required to build this exquisitely organized system are ultimately relevant to all other parts of the central nervous system.

Evolution of Visual and Non-visual Pigments

Evolution of Visual and Non-visual Pigments PDF

Author: David M. Hunt

Publisher: Springer

Published: 2014-10-04

Total Pages: 278

ISBN-13: 1461443555

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Photopigments are molecules that react to light and mediate a number of processes and behaviours in animals. Visual pigments housed within the photoreceptors of the eye, such as the rods and cones in vertebrates are the best known, however, visual pigments are increasingly being found in other tissues, including other retinal cells, the skin and the brain. Other closely related molecules from the G protein family, such as melanopsin mediate light driven processes including circadian rhythmicity and pupil constriction. This Volume examines the enormous diversity of visual pigments and traces the evolution of these G protein coupled receptors in both invertebrates and vertebrates in the context of the visual and non-visual demands dictated by a species’ ecological niche.

The Retina

The Retina PDF

Author: John E. Dowling

Publisher: Harvard University Press

Published: 2012-01-15

Total Pages: 610

ISBN-13: 0674247280

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John Dowling’s The Retina, published in 1987, quickly became the most widely recognized introduction to the structure and function of retinal cells. In this Revised Edition, Dowling draws on twenty-five years of new research to produce an interdisciplinary synthesis focused on how retinal function contributes to our understanding of brain mechanisms. The retina is a part of the brain pushed out into the eye during development. It retains many characteristics of other brain regions and hence has yielded significant insights on brain mechanisms. Visual processing begins there as a result of neuronal interactions in two synaptic layers that initiate an analysis of space, color, and movement. In humans, visual signals from 126 million photoreceptors funnel down to one million ganglion cells that convey at least a dozen representations of a visual scene to higher brain regions. The Revised Edition calls attention to general principles applicable to all vertebrate retinas, while showing how the visual needs of different animals are reflected in their retinal variations. It includes completely new chapters on color vision and retinal degenerations and genetics, as well as sections on retinal development and visual pigment biochemistry, and presents the latest knowledge and theories on how the retina is organized anatomically, physiologically, and pharmacologically. The clarity of writing and illustration that made The Retina a book of choice for a quarter century among graduate students, postdoctoral fellows, vision researchers, and teachers of upper-level courses on vision is retained in Dowling’s new easy-to-read Revised Edition.

The Neurobiology of Circadian Timing

The Neurobiology of Circadian Timing PDF

Author:

Publisher: Elsevier

Published: 2012-12-06

Total Pages: 513

ISBN-13: 044459454X

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Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future researchChapters are extensively referenced to provide readers with a comprehensive list of resources on the topics coveredAll chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Applications of Dynamical Systems in Biology and Medicine

Applications of Dynamical Systems in Biology and Medicine PDF

Author: Trachette Jackson

Publisher: Springer

Published: 2015-07-06

Total Pages: 240

ISBN-13: 1493927825

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This volume highlights problems from a range of biological and medical applications that can be interpreted as questions about system behavior or control. Topics include drug resistance in cancer and malaria, biological fluid dynamics, auto-regulation in the kidney, anti-coagulation therapy, evolutionary diversification and photo-transduction. Mathematical techniques used to describe and investigate these biological and medical problems include ordinary, partial and stochastic differentiation equations, hybrid discrete-continuous approaches, as well as 2 and 3D numerical simulation.

The Pupil: Behavior, Anatomy, Physiology and Clinical Biomarkers

The Pupil: Behavior, Anatomy, Physiology and Clinical Biomarkers PDF

Author: Andrew J. Zele

Publisher: Frontiers Media SA

Published: 2020-06-22

Total Pages: 306

ISBN-13: 2889637565

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Determining the Role of Phosphorylation of Mouse Melanopsin in Non-image Forming Vision

Determining the Role of Phosphorylation of Mouse Melanopsin in Non-image Forming Vision PDF

Author: Preethi Somasundaram

Publisher:

Published: 2017

Total Pages: 342

ISBN-13:

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Melanopsin is a visual pigment, expressed in intrinsically photosensitive retinal ganglion cells (ipRGCs) of the mammalian retina, that plays a major role in non-image forming visual behaviors like the pupillary light reflex, circadian photoentrainment, and sleep. It is hypothesized that melanopsin-mediated phototransduction is terminated by the phosphorylation of melanopsin’s C-terminus by a G-protein coupled receptor kinase, followed by -arrestin activation and binding. Little is known about the contribution of melanopsin phosphorylation to ipRGC physiology and its influence on non-image forming behaviors. We investigated the role of melanopsin C-terminus phosphorylation on non-image forming behaviors by generating a phosphorylation deficient melanopsin mutant that lacks all putative C-terminal phosphorylation sites (C-phosphonull).