Mechanisms of Conditional Fear Extinction in Mice
Author: Christopher Kenneth Cain
Publisher:
Published: 2004
Total Pages: 580
ISBN-13:
DOWNLOAD EBOOK →Author: Christopher Kenneth Cain
Publisher:
Published: 2004
Total Pages: 580
ISBN-13:
DOWNLOAD EBOOK →Author: Jerry J. Buccafusco
Publisher: CRC Press
Published: 2000-08-29
Total Pages: 341
ISBN-13: 1420041819
DOWNLOAD EBOOK →Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic
Author: Christopher Pittenger
Publisher: Oxford University Press
Published: 2017
Total Pages: 777
ISBN-13: 0190228164
DOWNLOAD EBOOK →Obsessive-compulsive disorder (OCD) affects one person in 40 and can cause great suffering. This volume provides the first comprehensive summary of our understanding of this enigmatic condition, summarizing current work ranging from genetics and neurobiology through cognitive psychology, treatment, personal experiences, and societal implications
Author: Mohammed R. Milad
Publisher: Springer Nature
Published: 2023-11-16
Total Pages: 386
ISBN-13: 3031430050
DOWNLOAD EBOOK →This book aims to provide the reader a neuroscientific understanding surrounding a very simple question: how do we learn not to fear? Exploring answers to this question is very important for two reasons. First, learning about the neural mechanisms of fear extinction is of relevance to everyone’s life - it is such a basic yet relevant question to our daily experiences. Therefore, understanding brain mechanisms of fear and its regulation is essential from a basic neuroscience point of view. Second, excessive fear and the inability to regulate its expression is one of the hallmarks of fear-, anxiety-, trauma-, and stressor-related psychopathologies. And as such, learning about how fear is acquired, stored, expressed, and regulated could help advance our understanding of the etiology of psychopathology, the maintenance of symptoms pertaining to failure to regulate fear, and could help us develop novel therapeutics to equip providers and patients with the tools to better quell their fears. The contributions contained in this book are provided by experts in the fields of basic and clinical neuroscience, experimental and clinical psychology, and neuropsychiatry. The contributions are organized to start the reader with basic definitions of how we define fear, how we study its neural circuits at the molecular and cellular levels, how to study human behavior and the brain using state-of-the art experimental and statistical tools, to how much fear contributes to psychopathology. This volume ends with current advances aimed to enhance the capacity to extinguish fear; a clinical result that would aid in the treatment of multiple psychiatric disorders, followed by a discussion on future directions of this highly important and relevant field.
Author: Y-h. Taguchi
Publisher: Springer Nature
Published: 2019-08-23
Total Pages: 321
ISBN-13: 3030224562
DOWNLOAD EBOOK →This book proposes applications of tensor decomposition to unsupervised feature extraction and feature selection. The author posits that although supervised methods including deep learning have become popular, unsupervised methods have their own advantages. He argues that this is the case because unsupervised methods are easy to learn since tensor decomposition is a conventional linear methodology. This book starts from very basic linear algebra and reaches the cutting edge methodologies applied to difficult situations when there are many features (variables) while only small number of samples are available. The author includes advanced descriptions about tensor decomposition including Tucker decomposition using high order singular value decomposition as well as higher order orthogonal iteration, and train tenor decomposition. The author concludes by showing unsupervised methods and their application to a wide range of topics. Allows readers to analyze data sets with small samples and many features; Provides a fast algorithm, based upon linear algebra, to analyze big data; Includes several applications to multi-view data analyses, with a focus on bioinformatics.
Author: J. David Sweatt
Publisher: Academic Press
Published: 2009-09-28
Total Pages: 362
ISBN-13: 0080959199
DOWNLOAD EBOOK →This fully revised second edition provides the only unified synthesis of available information concerning the mechanisms of higher-order memory formation. It spans the range from learning theory, to human and animal behavioral learning models, to cellular physiology and biochemistry. It is unique in its incorporation of chapters on memory disorders, tying in these clinically important syndromes with the basic science of synaptic plasticity and memory mechanisms. It also covers cutting-edge approaches such as the use of genetically engineered animals in studies of memory and memory diseases. Written in an engaging and easily readable style and extensively illustrated with many new, full-color figures to help explain key concepts, this book demystifies the complexities of memory and deepens the reader’s understanding. More than 25% new content, particularly expanding the scope to include new findings in translational research. Unique in its depth of coverage of molecular and cellular mechanisms Extensive cross-referencing to Comprehensive Learning and Memory Discusses clinically relevant memory disorders in the context of modern molecular research and includes numerous practical examples
Author: Edward D. Levin
Publisher: CRC Press
Published: 2006-06-22
Total Pages: 395
ISBN-13: 1420004336
DOWNLOAD EBOOK →The costs associated with a drug's clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairmen
Author: Ian Stolerman
Publisher: Springer Science & Business Media
Published: 2010-07-31
Total Pages: 1433
ISBN-13: 3540686983
DOWNLOAD EBOOK →Here is a broad overview of the central topics and issues in psychopharmacology, biological psychiatry and behavioral neurosciences, with information about developments in the field, including novel drugs and technologies. The more than 2000 entries are written by leading experts in pharmacology and psychiatry and comprise in-depth essays, illustrated with full-color figures, and are presented in a lucid style.
Author: Carolyn Eagan Jones
Publisher:
Published: 2015
Total Pages: 638
ISBN-13:
DOWNLOAD EBOOK →Pairing a neutral cue (e.g., a tone) with an inherently aversive unconditioned stimulus (US; e.g., a foot-shock) leads to future presentations of the now conditioned stimulus (CS) alone eliciting a conditioned response (e.g., freezing). This direct associative learning is only one technique under which individuals can learn about potential threats, but its convenient design and the robust production of responses makes direct fear conditioning the most frequently used paradigm in the research of fear and anxiety disorders. Fear can also be acquired from a social context, such as through observing the fear expression of a conspecific (Mineka et al., 1984, Mineka and Cook, 1993, Olsson et al., 2007, Olsson and Phelps, 2007). Utilizing a modified demonstrator-observer paradigm (fear conditioning by proxy) that allows for free interaction between subjects (see Bruchey et al., 2010; Jones et al., 2014), I explore the ability of rats to learn an associative fear response vicariously. In the experiments presented here, I (i) investigate the subject traits that bias rats to engage a social learning strategy; (ii) examine the neural mechanisms involved in this form of observational learning; and (iii) demonstrate how this paradigm can be incorporated into translationally-relevant tests of long term behavioral deficits resulting from early life trauma, in line with the health goals of the fear learning field in general (e.g., fear reduction). My results indicate that the identity of demonstrator animals as well as prior experience of the observer contributes to the expression of fear acquired vicariously. Additionally, I show that the social behaviors of caged rats are indicators of a social dominance hierarchy and are predictors of the potency of social fear transmission. This method of fear learning conserves some of the pathways necessary for direct fear learning (e.g., lateral amygdala) but is unique in that it requires regions necessary for executive control (e.g., anterior cingulate cortex) making the fear conditioning by proxy paradigm a novel tool for evaluating learning and behavior in the laboratory setting.
Author: Michelle G. Craske
Publisher: American Psychological Association (APA)
Published: 2006
Total Pages: 342
ISBN-13:
DOWNLOAD EBOOK →"The goal of this volume is to bring together the most recent empirical and theoretical developments in the basic science of fear learning and to translate these developments to the clinical understanding and treatment of fears and phobias. A major impetus for the volume was the recognition that basic science in fear learning is advancing far more rapidly than the clinical application of this knowledge. The book is structured to cover three main areas. The first presents the history of fear learning theory and fear measurement. The second area examines the acquisition and maintenance of fear, including neural circuitry, associative pathways, and cognitive mechanisms; the role of avoidance; and individual differences in fear learning. The third area covers the extinction, renewal, and reinstatement of fear, including neural circuitry and context dependency. The volume developed out of the Special Interest Meeting on Fear and Learning in Lignely, Belgium (May 2003), sponsored by the Fund for Scientific Research in Flanders, Belgium, and inspired by Paul Eelen. This volume is intended for both basic scientists and clinical scientists at undergraduate, graduate, and more advanced levels, as well as practicing clinicians who are interested in gaining an in-depth understanding of learning theory as it applies to fear and anxiety"--Preface. (PsycINFO Database Record (c) 2007 APA, all rights reserved)