Mechanism, Experiment, Disease

Mechanism, Experiment, Disease PDF

Author: Domenico Bertoloni Meli

Publisher: JHU Press

Published: 2011-05-02

Total Pages: 472

ISBN-13: 080189980X

DOWNLOAD EBOOK →

A leading early modern anatomist and physician, Marcello Malpighi often compared himself to that period’s other great mind—Galileo. Domenico Bertoloni Meli here explores Malpighi’s work and places it in the context of seventeenth-century intellectual life. Malpighi’s interests were wide and varied. As a professor at the University of Bologna, he confirmed William Harvey’s theory of the circulation of blood; published groundbreaking studies of human organs; made important discoveries about the anatomy of silkworms; and examined the properties of plants. He sought to apply his findings to medical practice. By analyzing Malpighi’s work, the author provides novel perspectives not only on the history of anatomy but also on the histories of science, philosophy, and medicine. Through the lens of Malpighi and his work, Bertoloni Meli investigates a range of important themes, from sense perception to the meaning of Galenism in the seventeenth century. Bertoloni Meli contends that to study science and medicine in the seventeenth century one needs to understand how scholars and ideas crossed disciplinary boundaries. He examines Malpighi’s work within this context, describing how anatomical knowledge was achieved and transmitted and how those processes interacted with the experimental and mechanical philosophies, natural history, and medical practice. Malpighi was central in all of these developments, and his work helped redefine the intellectual horizon of the time. Bertoloni Meli’s critical study of this key figure and the works of his contemporaries—including Borelli, Swammerdam, Redi, and Ruysch—opens a wonderful window onto the scientific and medical worlds of the seventeenth century.

Cellular Mechanisms in Alzheimer’s Disease

Cellular Mechanisms in Alzheimer’s Disease PDF

Author: Fernando A. Oliveira

Publisher: Bentham Science Publishers

Published: 2018-09-19

Total Pages: 237

ISBN-13: 1681087154

DOWNLOAD EBOOK →

Alzheimer’s Disease (AD) is the product of the slow and progressive degenerative alteration that develops in the adult brain and can remain asymptomatic for a considerable time before cognitive deficits becomes evident. The main challenge for researchers is to identify markers of this degenerative process, and, in this sense, data has been generated through experiments bringing to light new mechanisms and hypothesis to explain its pathophysiology. This book is a review of recent studies in AD molecular biology. Chapters explain various facets of AD, which include animal models, morphological changes, membrane composition, amyloidogenic peptides, intracellular transport systems, and the role of oxidative stress and calcium deregulation. Readers will understand the molecular mechanisms behind AD and therefore broaden their perspective on this neurodegenerative disease and its progression.

Schaechter's Mechanisms of Microbial Disease

Schaechter's Mechanisms of Microbial Disease PDF

Author: Moselio Schaechter

Publisher: Lippincott Williams & Wilkins

Published: 2007

Total Pages: 800

ISBN-13: 9780781753425

DOWNLOAD EBOOK →

Now in full color, the Fourth Edition of this text gives students a thorough understanding of microbial agents and the pathophysiology of microbial diseases. The text facilitates learning and recall by emphasizing unifying principles and paradigms, rather than forcing students to memorize isolated facts by rote. Case studies with problem-solving questions give students insight into clinical applications of microbiology. Each chapter ends with review and USMLE-style questions. For this edition, all schematic illustrations have been re-rendered in full color and new illustrations have been added. A new online site for students includes animations, USMLE-style questions, and all schematic illustrations and photographs from the text.

Evaluating Evidence of Mechanisms in Medicine

Evaluating Evidence of Mechanisms in Medicine PDF

Author: Veli-Pekka Parkkinen

Publisher: Springer

Published: 2018-07-13

Total Pages: 125

ISBN-13: 3319946102

DOWNLOAD EBOOK →

This book is open access under a CC BY license. This book is the first to develop explicit methods for evaluating evidence of mechanisms in the field of medicine. It explains why it can be important to make this evidence explicit, and describes how to take such evidence into account in the evidence appraisal process. In addition, it develops procedures for seeking evidence of mechanisms, for evaluating evidence of mechanisms, and for combining this evaluation with evidence of association in order to yield an overall assessment of effectiveness. Evidence-based medicine seeks to achieve improved health outcomes by making evidence explicit and by developing explicit methods for evaluating it. To date, evidence-based medicine has largely focused on evidence of association produced by clinical studies. As such, it has tended to overlook evidence of pathophysiological mechanisms and evidence of the mechanisms of action of interventions. The book offers a useful guide for all those whose work involves evaluating evidence in the health sciences, including those who need to determine the effectiveness of health interventions and those who need to ascertain the effects of environmental exposures.

Mechanisms of Disease

Mechanisms of Disease PDF

Author: Stephen Tomlinson

Publisher: Cambridge University Press

Published: 2008-03-20

Total Pages: 305

ISBN-13: 1139469495

DOWNLOAD EBOOK →

To reflect the changing face of undergraduate and postgraduate medical education, this new edition emphasises the principles of disease processes and their underlying mechanisms, bringing the content up to date with the latest developments from the fields of molecular and cellular biology. The focus is on describing the fundamental features of pathophysiological processes with examples to illustrate the similar mechanisms underlying apparently diverse clinical conditions. By understanding the cellular interactions in one disease area, similar principles can be applied to other disease groups and to the scientific basis of medical management and treatment strategies. Throughout, the student is encouraged to evaluate and integrate the evidence critically, developing skills for self-directed learning and the application of knowledge. To further encourage the reader to integrate the theory with clinical practice, each chapter concludes with a series of clinical scenarios and MCQs, with answers provided.

Vitamin C in Human Health and Disease

Vitamin C in Human Health and Disease PDF

Author: Wang Jae Lee

Publisher: Springer

Published: 2019-08-06

Total Pages: 184

ISBN-13: 9402417133

DOWNLOAD EBOOK →

This book presents the scientific evidence for the role of vitamin C in health and disease and offers new guidance on vitamin C intake in humans. The importance of vitamin C in preventing cancer and cardiovascular disease, its relevance to aging and stress, and its impacts on each of the human body systems are thoroughly assessed on the basis of the author’s extensive research and his deep understanding, as an anatomy professor, of the body as a whole. Findings published in the international scientific literature are fully taken into account, and due consideration is also given to empirical evidence, bearing in mind that mechanisms of action cannot always be precisely defined in the absence of human experiments. Beyond providing an up-to-date scientific perspective on the effects of vitamin C, the author hopes to promote human health worldwide by encouraging proper use of the vitamin. To this end, recommendations are made on the amount of vitamin C that should be taken daily and on the best way to take it. The book will be of interest to researchers, clinicians, and all others who wish to learn more about this vitamin and its significance.