Measuring Biological Impacts of Nanomaterials

Measuring Biological Impacts of Nanomaterials PDF

Author: Joachim Wegener

Publisher: Springer

Published: 2016-02-02

Total Pages: 221

ISBN-13: 3319248235

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This book reviews several aspects of the biological response to nanoscale particles on a molecular and cellular level. Nanoscale materials and nanoscale particles in particular have interesting properties and beneficial applications. While they thus have entered our daily lifes on many different levels (from electronics, over textiles, packaging or surface modifications, to biomedical applications), general rules describing their interaction with biological structures and biological matter are still difficult to derive. The existing literature suggests a variety of interaction schemes between nanoparticles and biological objects, not dispelling the public concerns about possible health effects and harmful properties. A systematic approach to the problem is needed and timely. This book specifically emphasizes bioanalytical problems starting from the characterization of the nanomaterials to the pitfalls and potential artifacts of state-of-the-art cytotoxicity assays that are frequently used to study harmful effects on cells. It also highlights the application of label-free bioanalytical techniques that can potentially complement the present approaches and hence provide new perspectives on this highly discussed cutting-edge field of research and public concern.

Biological Responses to Nanoscale Particles

Biological Responses to Nanoscale Particles PDF

Author: Peter Gehr

Publisher: Springer

Published: 2019-04-16

Total Pages: 344

ISBN-13: 3030124614

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In this book the recent progress accumulated in studies of the interaction of engineered nanoparticles with cells and cellular constituents is presented. The focus is on manufacturing and characterization of nanosized materials, their interactions with biological molecules such as proteins, the mechanisms of transport across biological membranes as well as their effects on biological functions. Fundamental molecular and cellular aspects are in the foreground of the book. A further particularity is the interdisciplinary approach, including fields such as preparatory and analytical chemistry, biophysics and the physics of colloids, advanced microscopy and spectroscopy for in-situ detection of nanoparticles, cellular toxicology and nanomedicine. Nanoscale particles are known to exhibit novel and unprecedented properties that make them different from their corresponding bulk materials. As our ability to control these properties is further advanced, a huge potential to create materials with novel properties and applications emerges. Although the technological and economic benefits of nanomaterials are indisputable, concerns have also been raised that nanoscale structuring of materials might also induce negative health effects. Unfortunately, such negative health effects cannot be deduced from the known toxicity of the corresponding macroscopic material. As a result, there is a major gap in the knowledge necessary for assessing their risk to human health.

Toxicology of Nanoparticles: Insights from Drosophila

Toxicology of Nanoparticles: Insights from Drosophila PDF

Author: Namita Agrawal

Publisher: Springer Nature

Published: 2020-08-24

Total Pages: 128

ISBN-13: 9811555222

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This book offers an unparalleled source of information on in vivo assessment of nanoparticle toxicity by using Drosophila as a model organism. Nanoparticles have emerged as an useful tool for wide variety of biomedical, cosmetics, and industrial applications. However, our understanding of nanomaterial-mediated toxicity under in vivo condition remains limited. The book begins with a chapter on synthesis and characterization of nanoparticles used for various biological, medical and commercial purposes. The rest of the chapters deal with the impact of nanoparticles on different biological aspects like behavior, physiology and metabolic homoeostasis using Drosophila as a model organism. Lastly, the book summarizes how proper characterization and evaluation of safe dosage of nanoparticles can be a boon if incorporated in consumer goods and for biomedical applications. Overall, the book pursues an interdisciplinary approach by connecting nanotechnology and biology from various angles using Drosophila as a model system, so as to develop more efficient, safe and effective use of nanoparticles for human beings.

Characterization of Nanomaterials in Complex Environmental and Biological Media

Characterization of Nanomaterials in Complex Environmental and Biological Media PDF

Author:

Publisher: Elsevier

Published: 2015-06-01

Total Pages: 321

ISBN-13: 0080999506

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Characterization of Nanomaterials in Complex Environmental and Biological Media covers the novel properties of nanomaterials and their applications to consumer products and industrial processes. The book fills the growing gap in this challenging area, bringing together disparate strands in chemistry, physics, biology, and other relevant disciplines. It provides an overview on nanotechnology, nanomaterials, nano(eco)toxicology, and nanomaterial characterization, focusing on the characterization of a range of nanomaterial physicochemical properties of relevance to environmental and toxicological studies and their available analytical techniques. Readers will find a multidisciplinary approach that provides highly skilled scientists, engineers, and technicians with the tools they need to understand and interpret complicated sets of data obtained through sophisticated analytical techniques. Addresses the requirements, challenges, and solutions for nanomaterial characterization in environmentally complex media Focuses on technique limitations, appropriate data collection, data interpretation, and analysis Aids in understanding and comparing nanomaterial characterization data reported in the literature using different analytical tools Includes case studies of characterization relevant complex media to enhance understanding

Environmental and Biochemical Toxicology

Environmental and Biochemical Toxicology PDF

Author: Jürgen Gailer

Publisher: Walter de Gruyter GmbH & Co KG

Published: 2022-06-21

Total Pages: 424

ISBN-13: 3110626349

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This text coherently links biochemical fundamentals and mechanisms with economic and societal problems of environmental pollution. It addresses interdisciplinary topics such as regulatory problems, sampling and pollutant quantifi cation, model organisms and provides a philosophical perspective on the toxin load on a variety of organisms, including humans in the environment in the Anthropocene. Case studies and exercises illustrate current issues and discuss future aspects.

Environmental Nanotechnology

Environmental Nanotechnology PDF

Author: Mark Wiesner

Publisher: McGraw Hill Professional

Published: 2007-06-05

Total Pages: 554

ISBN-13: 0071511040

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Explore the Properties of Today's Widely Used Nanomaterials— and Assess Their Potentially Harmful Effects on the Environment Environmental Nanotechnology is the first book to assist you in both understanding the properties of new nanomaterial-centered technology and assessing the potentially harmful effects these materials may have on the environment. Written by a team of 29 leading experts from around the world, this comprehensive book presents cutting-edge coverage of the fabrication, characterization, and measurement of nanomaterials...emerging markets for nanomaterials...nanotechnologies in the energy industry...nanotechnologies for environmental quality...nanotechnology transport and fate in the environment...toxicological impacts of nanomaterials...and much more. Filled with detailed illustrations, Environmental Nanotechnology features: State-of-the-art techniques for the characterization and measurement of nanomaterials The latest findings on the transport and fate of nanomaterials in the environment Nanotechnologies for energy production, storage, and distribution In-depth analyses of the ecotoxicological impacts of nanomaterials New methods for developing nanomaterials with less environmental risk Inside This Landmark Environmental Engineering Guide _ • Nanomaterials: New Challenges and Opportunities • Fabrication of Nanomaterials • Characterization and Measurement of Nanomaterials • Emerging Markets for Nanomaterials • Nanomaterial-Enabled Technologies for Energy Production, Storage, and Distribution • Nanomaterial-Enabled Technologies for Environmental Quality • Nanomaterial Transport and Fate in the Environment • Ecotoxicological Impacts of Nanomaterials • Toxicological Impacts of Nanomaterials

Nanofabrication Towards Biomedical Applications

Nanofabrication Towards Biomedical Applications PDF

Author: Challa S. S. R. Kumar

Publisher: John Wiley & Sons

Published: 2006-03-06

Total Pages: 442

ISBN-13: 352760460X

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This book focuses on the materials, synthetic methods, tools and techniques being developed in the nanoregime towards the life sciences -- in particular biology, biotechnology and medicine. Readers from materials science, engineering, chemistry, biology and medical backgrounds will find detailed accounts of the design and synthesis of nanomaterials and the tools and techniques involved in their production for applications in biology, biotechnology and medicine.

Biological Responses to Engineered Nanomaterials

Biological Responses to Engineered Nanomaterials PDF

Author:

Publisher:

Published: 2015

Total Pages:

ISBN-13:

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The interaction of nanomaterials with biomolecules, cells, and organisms is an enormously vital area of current research, with applications in nanoenabled diagnostics, imaging agents, therapeutics, and contaminant removal technologies. Yet the potential for adverse biological and environmental impacts of nanomaterial exposure is considerable and needs to be addressed to ensure sustainable development of nanomaterials. In this Outlook four research needs for the next decade are outlined: (i) measurement of the chemical nature of nanomaterials in dynamic, complex aqueous environments; (ii) real-time measurements of nanomaterial-biological interactions with chemical specificity; (iii) delineation of molecular modes of action for nanomaterial effects on living systems as functions of nanomaterial properties; and (iv) an integrated systems approach that includes computation and simulation across orders of magnitude in time and space.

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