Mathematical Modelling in Medicine

Mathematical Modelling in Medicine PDF

Author: Johnny T. Ottesen

Publisher: IOS Press

Published: 2000

Total Pages: 248

ISBN-13: 9781586030261

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Title page -- Preface -- Contents -- Part I. Heart -- The Changing View of the HeartThrough the Centuries -- The Left Ventricular Ejection Effect -- Human Circulatory System Model Based On Frank's Mechanism -- Modelling Blood Flow in the Left Side of the Heart -- Part II: Arterial Tree -- Models of the Arterial Tree -- A One-Dimensional Fluid Dynamic Model of the Systemic Arteries -- Measurement of Arterial Compliance In Vivo -- Models of the Venous System -- Part III: Baroreceptor Control -- General Compartmental Models of the Cardiovascular System -- Modelling the Interaction Among Several Mechanisms in the Short-term Arterial Pressure Control -- Short term Autonomic Nervous Control of the Cardiovascular System: A System Theoretic Approach -- A Baroreflex Model of Short Term Blood Pressure and Heart Rate Variability -- Part IV: Applications for Simulators -- Mathematical Models Behind Advanced Simulators in Medicine -- Cognitive Studies of Ethical Reasoning Basedon the KARDIO-simulator -- Index -- Author Index

Aspects of Mathematical Modelling

Aspects of Mathematical Modelling PDF

Author: Roger J. Hosking

Publisher: Springer Science & Business Media

Published: 2008-03-02

Total Pages: 373

ISBN-13: 376438591X

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The construction of mathematical models is an essential scientific activity. Mathematics is associated with developments in science and engineering, but more recently mathematical modelling has been used to investigate complex systems that arise in other fields. This book demonstrates the application of mathematics to research topics in ecology and environmental science, health and medicine, phylogenetics and neural networks, theoretical chemistry, economics and management.

Mathematical Modeling in Nutrition and the Health Sciences

Mathematical Modeling in Nutrition and the Health Sciences PDF

Author: Janet A. Novotny

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 437

ISBN-13: 1441990194

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This volume is the proceedings of the 7th Mathematical Modeling in Experimental Nutrition Conference held at Penn State University July 29 until August 1, 2000. The book addresses the determination of optimal intakes of nutrients and food components to provide lifelong health and reduce incidence of disease. Mathematical modelling provides a means of rigorously defining the functions of a system and using a variety of conditions to stimulate responses. This volume presents the newest advances in modelling and related experimental techniques required to meet the new challenges currently facing nutrition and biological science.

Mathematical Modeling in Systems Biology

Mathematical Modeling in Systems Biology PDF

Author: Brian P. Ingalls

Publisher: MIT Press

Published: 2022-06-07

Total Pages: 423

ISBN-13: 0262545829

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An introduction to the mathematical concepts and techniques needed for the construction and analysis of models in molecular systems biology. Systems techniques are integral to current research in molecular cell biology, and system-level investigations are often accompanied by mathematical models. These models serve as working hypotheses: they help us to understand and predict the behavior of complex systems. This book offers an introduction to mathematical concepts and techniques needed for the construction and interpretation of models in molecular systems biology. It is accessible to upper-level undergraduate or graduate students in life science or engineering who have some familiarity with calculus, and will be a useful reference for researchers at all levels. The first four chapters cover the basics of mathematical modeling in molecular systems biology. The last four chapters address specific biological domains, treating modeling of metabolic networks, of signal transduction pathways, of gene regulatory networks, and of electrophysiology and neuronal action potentials. Chapters 3–8 end with optional sections that address more specialized modeling topics. Exercises, solvable with pen-and-paper calculations, appear throughout the text to encourage interaction with the mathematical techniques. More involved end-of-chapter problem sets require computational software. Appendixes provide a review of basic concepts of molecular biology, additional mathematical background material, and tutorials for two computational software packages (XPPAUT and MATLAB) that can be used for model simulation and analysis.

Mathematical Models in Medicine

Mathematical Models in Medicine PDF

Author: J. Berger

Publisher: Springer

Published: 1976-08-20

Total Pages: 312

ISBN-13:

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This work contains the congresses from a 1976 conference at Mainz, which evaluated the possibilities and limitations of mathematical models in the medical field.

Modeling and Simulation in Medicine and the Life Sciences

Modeling and Simulation in Medicine and the Life Sciences PDF

Author: Frank C. Hoppensteadt

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 362

ISBN-13: 0387215719

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The result of lectures given by the authors at New York University, the University of Utah, and Michigan State University, the material is written for students who have had only one term of calculus, but it contains material that can be used in modeling courses in applied mathematics at all levels through early graduate courses. Numerous exercises are given as well as solutions to selected exercises, so as to lead readers to discover interesting extensions of that material. Throughout, illustrations depict physiological processes, population biology phenomena, corresponding models, and the results of computer simulations. Topics covered range from population phenomena to demographics, genetics, epidemics and dispersal; in physiological processes, including the circulation, gas exchange in the lungs, control of cell volume, the renal counter-current multiplier mechanism, and muscle mechanics; to mechanisms of neural control. Each chapter is graded in difficulty, so a reading of the first parts of each provides an elementary introduction to the processes and their models.

Mathematical Modelling

Mathematical Modelling PDF

Author: J. Caldwell

Publisher: Springer Science & Business Media

Published: 2006-04-10

Total Pages: 252

ISBN-13: 1402019939

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Over the past decade there has been an increasing demand for suitable material in the area of mathematical modelling as applied to science, engineering, business and management. Recent developments in computer technology and related software have provided the necessary tools of increasing power and sophistication which have significant implications for the use and role of mathematical modelling in the above disciplines. In the past, traditional methods have relied heavily on expensive experimentation and the building of scaled models, but now a more flexible and cost effective approach is available through greater use of mathematical modelling and computer simulation. In particular, developments in computer algebra, symbolic manipulation packages and user friendly software packages for large scale problems, all have important implications in both the teaching of mathematical modelling and, more importantly, its use in the solution of real world problems. Many textbooks have been published which cover the art and techniques of modelling as well as specific mathematical modelling techniques in specialist areas within science and business. In most of these books the mathematical material tends to be rather tailor made to fit in with a one or two semester course for teaching students at the undergraduate or postgraduate level, usually the former. This textbook is quite different in that it is intended to build on and enhance students’ modelling skills using a combination of case studies and projects.

Computational Modeling in Biomedical Engineering and Medical Physics

Computational Modeling in Biomedical Engineering and Medical Physics PDF

Author: Alexandru Morega

Publisher: Academic Press

Published: 2020-10-02

Total Pages: 320

ISBN-13: 0128178973

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Mathematical and numerical modelling of engineering problems in medicine is aimed at unveiling and understanding multidisciplinary interactions and processes and providing insights useful to clinical care and technology advances for better medical equipment and systems. When modelling medical problems, the engineer is confronted with multidisciplinary problems of electromagnetism, heat and mass transfer, and structural mechanics with, possibly, different time and space scales, which may raise concerns in formulating consistent, solvable mathematical models. Computational Medical Engineering presents a number of engineering for medicine problems that may be encountered in medical physics, procedures, diagnosis and monitoring techniques, including electrical activity of the heart, hemodynamic activity monitoring, magnetic drug targeting, bioheat models and thermography, RF and microwave hyperthermia, ablation, EMF dosimetry, and bioimpedance methods. The authors discuss the core approach methodology to pose and solve different problems of medical engineering, including essentials of mathematical modelling (e.g., criteria for well-posed problems); physics scaling (homogenization techniques); Constructal Law criteria in morphing shape and structure of systems with internal flows; computational domain construction (CAD and, or reconstruction techniques based on medical images); numerical modelling issues, and validation techniques used to ascertain numerical simulation results. In addition, new ideas and venues to investigate and understand finer scale models and merge them into continuous media medical physics are provided as case studies. Presents the fundamentals of mathematical and numerical modeling of engineering problems in medicine Discusses many of the most common modelling scenarios for Biomedical Engineering, including, electrical activity of the heart hemodynamic activity monitoring, magnetic drug targeting, bioheat models and thermography, RF and microwave hyperthermia, ablation, EMF dosimetry, and bioimpedance methods Includes discussion of the core approach methodology to pose and solve different problems of medical engineering, including essentials of mathematical modelling, physics scaling, Constructal Law criteria in morphing shape and structure of systems with internal flows, computational domain construction, numerical modelling issues, and validation techniques used to ascertain numerical simulation results