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Mass Spectrometry in the Biological Sciences: A Tutorial

Author: M.L Gross

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 462

ISBN-13: 9401126186

The developments in mass spectrometry over the past fifteen years have been impressive in their implications in bioanalytical chemistry. The achievements begin with the inventions of Cf-252 Plasma Desorption Mass Spectrometry by Macfarlane and Fourier Transform Mass Spectrometry by Comisarow and Marshall in the mid 1970s. The former showed the feasibility of producing large gas-phase ions from large biomolecules whereas the latter enhanced the capabilities for ion trapping especially in analytical mass spectrometry. A major achievement was the development by Barber of Fast Atom Bombardment (FAB) mass spectrometry, an advance that heralded a new era in biological mass spectrometry. Contemporary and routine instruments such as magnetic sectors and quadrupoles were rapidly adapted to F AB, and nearly the entire universe of small molecules became amenable to study by mass spectrometry. The introduction of FAB also paved the way for improvement of instrument capability. For example, the upper mass limit of magnet sector mass spectrometers was increased by nearly an order of magnitude by the instrument manufacturers. Furthermore, the technique of tandem mass spectrometry (MS/MS) was given new meaning because important structural information for biomolecules could now be produced for ions introduced by FAB into the tandem instrument. The evolution of MS/MS continues today with the development of ion traps, time-of-flight, and sector instruments equipped with array detection.

Mass Spectrometry in the Biological Sciences

Author: A. L. Burlingame

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 569

ISBN-13: 1461202299

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Leading practitioners describe in detail advanced methods of mass spectrometry used in structural characterization of biomacromolecules of both natural and recombinant origin. They demonstrate by example how these methodologies can solve a wide array of real-world problems in protein biochemistry, immunology, and glycobiology, as well as for human bacterial pathogens, lipids, and nucleic acids. The book offers a unique opportunity to learn these techniques that are revolutionizing the field. Its authoritative assessment in the context of how to solve important and challenging problems in bioscience and medicine ensures a competitive advantage for today's researchers.

Analyzing Biomolecular Interactions by Mass Spectrometry

Author: Jeroen Kool

Publisher: John Wiley & Sons

Published: 2015-05-04

Total Pages: 402

ISBN-13: 3527334645

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This monograph reviews all relevant technologies based on mass spectrometry that are used to study or screen biological interactions in general. Arranged in three parts, the text begins by reviewing techniques nowadays almost considered classical, such as affinity chromatography and ultrafiltration, as well as the latest techniques. The second part focusses on all MS-based methods for the study of interactions of proteins with all classes of biomolecules. Besides pull down-based approaches, this section also emphasizes the use of ion mobility MS, capture-compound approaches, chemical proteomics and interactomics. The third and final part discusses other important technologies frequently employed in interaction studies, such as biosensors and microarrays. For pharmaceutical, analytical, protein, environmental and biochemists, as well as those working in pharmaceutical and analytical laboratories.

Mass Spectrometry of Biological Materials, Second Edition

Author: Barbara S. Larsen

Publisher: CRC Press

Published: 1998-03-02

Total Pages: 490

ISBN-13: 9780824701574

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Second Edition provides up-to-the-minute discussions on the application of mass spectrometry to the biological sciences. Shows how and why experiments are performed and furnishes details to facilitate duplication of results.

Mass Spectrometry in Biomolecular Sciences

Author: Richard M. Caprioli

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 531

ISBN-13: 9400902174

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Mass Spectrometry in the Biological Sciences covers the most recent technological and applied developments in the area, including both ionization techniques and ion analysis. It introduces and reviews some of the newer ionization methods, describes the major instrumentation involved in mass analysis, and presents the scope of the technology in biology, medicine, and environmental science. Specific examples are given for a number of topics. It also deals with recent achievements in the on-line combination of separation techniques such as gas chromatography, liquid chromatography, and supercritical fluid technology.

Selected Topics in Mass Spectrometry in the Biomolecular Sciences

Author: Richard M. Caprioli

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 589

ISBN-13: 9401151652

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Many fundamental aspects of the methods used in mass spectrometry are here presented by outstanding scientists, with reference to very recent developments. The principles and applications of electrospray, ion spray and MALDI ionization technique are presented, together with optimised GC/MS interfacing systems and tools for quantitative analysis. A comprehensive treatment of modern instrumentation for mass analysis and detection is also included. The major part of the book deals with bioanalytical applications to peptides, proteins, oligonucleotides, polysaccharides, lipids and plant metabolites. Several papers are devoted to the evaluation of adduct formation between DNA and carcinogens. Environmental applications are also included, with examples of some specific cases. Fundamentals and applications are treated with the same degree of depth: the first two parts of the book therefore provide a basis for the understanding of the biomolecular applications section. Audience: Ideal for advanced graduate students of chemistry who have learned some basic mass spectrometry. Also useful for Ph.D. students in chemistry, biology and medicine. Of value to researchers in academic and industrial laboratories.

Introduction to Mass Spectrometry

Author: J. Throck Watson

Publisher: John Wiley & Sons

Published: 2013-07-09

Total Pages: 972

ISBN-13: 1118681584

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Completely revised and updated, this text provides an easy-to-read guide to the concept of mass spectrometry and demonstrates its potential and limitations. Written by internationally recognised experts and utilising "real life" examples of analyses and applications, the book presents real cases of qualitative and quantitative applications of mass spectrometry. Unlike other mass spectrometry texts, this comprehensive reference provides systematic descriptions of the various types of mass analysers and ionisation, along with corresponding strategies for interpretation of data. The book concludes with a comprehensive 3000 references. This multi-disciplined text covers the fundamentals as well as recent advance in this topic, providing need-to-know information for researchers in many disciplines including pharmaceutical, environmental and biomedical analysis who are utilizing mass spectrometry

Biological Mass Spectrometry

Author: T. Matsuo

Publisher:

Published: 1994-05-10

Total Pages: 698

ISBN-13:

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Prominent active researchers present comprehensive reviews of modern biological mass spectrometry (BMS) including an excellent introduction to the instrumentation and applications currently being implemented. Profiles such recent techniques as ESI, MALDI, LC/MS, Ion-Trap and FT/ICR. Contains specific applications to proteins, drugs and natural products. Features practical guidance for problem solving within the biological sciences. Provides a detailed record of BMS in the early 90s which will serve as a reference in years to come.

Analyzing Biomolecular Interactions by Mass Spectrometry

Author: Jeroen Kool

Publisher: John Wiley & Sons

Published: 2015-02-09

Total Pages: 400

ISBN-13: 3527673415

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Mass Spectrometry for Biotechnology

Author: Gary Siuzdak

Publisher: Elsevier

Published: 1996-02-12

Total Pages: 179

ISBN-13: 0080535844

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If you investigate biological systems and might use mass spectrometry in your research but need to know more about it, this book is for you. It introduces the fundamental concepts of mass spectrometry and how mass spectrometers work. It also presents recent advancements particularly interesting to bio-researchers in an easy-to-understand manner that does not require extensive background in chemistry, math, or physics. Glossary of basic terms Abundant illustrations Examples of applications Practical tips on using mass spectrometric techniques Useful for peptide, protein, oligonucleotide, and carbohydrate analysis Simplified description of mass spectrometry including: Matrix-Assisted Laser Desorption/Ionization (MALDI) Electrospray Ionization (ESI) Fast Atom/Ion Bombardment (FAB)