Pathway Analysis for Drug Discovery

Pathway Analysis for Drug Discovery PDF

Author: Anton Yuryev

Publisher: John Wiley & Sons

Published: 2008-09-17

Total Pages: 332

ISBN-13: 0470399260

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This book introduces drug researchers to the novel computational approaches of pathway analysis and explains the existing applications that can save time and money in the drug discovery process. It covers traditional computational methods and software for pathway analysis microarray, proteomics, and metabolomics. It explains pathway reconstruction of diseases and toxic states, pathway analysis in various phases, dynamic modeling of drug responses, and more. This is a core resource for drug discovery and pharmaceutical industry researchers, chemists, and biologists and for professionals in related fields.

Systems Biology in Cancer Research and Drug Discovery

Systems Biology in Cancer Research and Drug Discovery PDF

Author: Asfar S Azmi

Publisher: Springer Science & Business Media

Published: 2012-09-29

Total Pages: 425

ISBN-13: 9400748191

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Systems Biology in Cancer Research and Drug Discovery provides a unique collection of chapters, by world-class researchers, describing the use of integrated systems biology and network modeling in the cancer field where traditional tools have failed to deliver expected promise. This book touches four applications/aspects of systems biology (i) in understanding aberrant signaling in cancer (ii) in identifying biomarkers and prognostic markers especially focused on angiogenesis pathways (iii) in unwinding microRNAs complexity and (iv) in anticancer drug discovery and in clinical trial design. This book reviews the state-of-the-art knowledge and touches upon cutting edge newer and improved applications especially in the area of network modeling. It is aimed at an audience ranging from students, academics, basic researcher and clinicians in cancer research. This book is expected to benefit the field of translational cancer medicine by bridging the gap between basic researchers, computational biologists and clinicians who have one ultimate goal and that is to defeat cancer.

Data Mining in Drug Discovery

Data Mining in Drug Discovery PDF

Author: Rémy D. Hoffmann

Publisher: John Wiley & Sons

Published: 2013-09-25

Total Pages: 322

ISBN-13: 3527656006

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Written for drug developers rather than computer scientists, this monograph adopts a systematic approach to mining scientifi c data sources, covering all key steps in rational drug discovery, from compound screening to lead compound selection and personalized medicine. Clearly divided into four sections, the first part discusses the different data sources available, both commercial and non-commercial, while the next section looks at the role and value of data mining in drug discovery. The third part compares the most common applications and strategies for polypharmacology, where data mining can substantially enhance the research effort. The final section of the book is devoted to systems biology approaches for compound testing. Throughout the book, industrial and academic drug discovery strategies are addressed, with contributors coming from both areas, enabling an informed decision on when and which data mining tools to use for one's own drug discovery project.

Pathways to Discovery in Astronomy and Astrophysics for the 2020s

Pathways to Discovery in Astronomy and Astrophysics for the 2020s PDF

Author: National Academies of Sciences, Engineering, and Medicine

Publisher:

Published: 2022-08-04

Total Pages: 615

ISBN-13: 9780309467346

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The steering committee was specifically asked to (1) provide an overview of the current state of astronomy and astrophysics science, and technology research in support of that science, with connections to other scientific areas where appropriate; (2) identify the most compelling science challenges and frontiers in astronomy and astrophysics, which shall motivate the committee’s strategy for the future; (3) develop a comprehensive research strategy to advance the frontiers of astronomy and astrophysics for the period 2022-2032 that will include identifying, recommending, and ranking the highest-priority research activities; (4) utilize and recommend decision rules, where appropriate, that can accommodate significant but reasonable deviations in the projected budget or changes in urgency precipitated by new discoveries or unanticipated competitive activities; (5) assess the state of the profession, including workforce and demographic issues in the field, identify areas of concern and importance to the community, and where possible, provide specific, actionable, and practical recommendations to the agencies and community to address these areas. This report proposes a broad, integrated plan for space- and ground-based astronomy and astrophysics for the decade 2023-2032. It also lays the foundations for further advances in the following decade.

Experimentation in Mathematics

Experimentation in Mathematics PDF

Author: Jonathan M. Borwein

Publisher: CRC Press

Published: 2004-04-12

Total Pages: 372

ISBN-13: 1439864195

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New mathematical insights and rigorous results are often gained through extensive experimentation using numerical examples or graphical images and analyzing them. Today computer experiments are an integral part of doing mathematics. This allows for a more systematic approach to conducting and replicating experiments. The authors address the role of

Biochips as Pathways to Drug Discovery

Biochips as Pathways to Drug Discovery PDF

Author: Andrew Carmen

Publisher: CRC Press

Published: 2006-10-19

Total Pages: 420

ISBN-13: 1420015605

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In the fiercely competitive pharmaceutical marketplace, your organization cannot afford to spend excess dollars developing drugs that will fail to get FDA approval or have profoundly poor characteristics. Biochips as Pathways to Drug Discovery takes a comprehensive look at how the industry faces these challenges, using new technologies such as bioc

Drug Discovery Toxicology

Drug Discovery Toxicology PDF

Author: Yvonne Will

Publisher: John Wiley & Sons

Published: 2016-03-22

Total Pages: 584

ISBN-13: 1119053390

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As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods • Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices

Many Pathways for Discovery

Many Pathways for Discovery PDF

Author: Casey A. Mullin

Publisher: A-R Editions, Inc.

Published:

Total Pages: 164

ISBN-13: 0895799111

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Many Pathways for Discovery is a manual for metadata practitioners learning music cataloging for the first time, as well as a ready reference tool for more experienced practitioners. It is intended to serve as a companion guide to general music cataloging instruction, focusing on what has traditionally been considered the more advanced skillset of “subject analysis.” It provides guidance for answering the “W-questions” about music content: What is it? (genre/form); What is it for, or, How is it performed? (medium of performance); Who is it by and Who is it for? (demographic aspects); When was it created? (chronological aspects); Where was it created? (geographic aspects) This book is primarily geared toward a metadata environment based on MARC 21 encoding and on vocabularies developed by the Library of Congress, namely, the Medium of Performance Thesaurus for Music (LCMPT), the Genre/Form Terms for Library and Archival Materials (LCGFT), and the Demographic Group Terms (LCDGT). Comparisons to legacy practices involving Library of Congress Subject Headings (LCSH) are included. Additional chapters address encoding of faceted descriptors in Linked Data environments, and on discovery possibilities for end users. A bibliography of foundational and supplemental resources is provided.

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