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Lymphocyte Homing to the Skin

Author: Wolf-Henning Boehncke

Publisher: CRC Press

Published: 2004-12-28

Total Pages: 212

ISBN-13: 1420019643

Over the last decade, enormous progress in the understanding of T-cell homing has made it possible to identify the multitude of molecules involved, such as cytokines, chemokines, and adhesion molecules, and to unravel their complex interactions resulting in controlled, non-random T-cell recirculation. These insights are now being explored therapeut

Leucocyte Trafficking

Author: A. Hamann

Publisher: Springer Science & Business Media

Published: 2013-06-29

Total Pages: 258

ISBN-13: 3662053977

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An essential component of inflammation is the migration of circulating leukocytes from blood into tissues. This process is characterized by a multistep paradigm of sequential cell adhesion and activation events that lead to the extravasation of specific leukocyte subsets to different tissues in health and disease. The first step of leukocyte extravasation, the rolling of leukocytes, is primarily mediated by the interactions of selectins and their ligands. It has recently become evident that fucosyltransferases are crucial for selectin ligand synthesis, inflammation, and skin homing. This book provides an in-depth overview of the mechanisms of leukocyte trafficking and of the molecular mechanisms of selectin/selectin ligand interactions and discusses options for pharmacological intervention to treat inflammatory diseases.

Microcirculation

Author: Ronald F. Tuma

Publisher: Academic Press

Published: 2011-04-28

Total Pages: 1000

ISBN-13: 9780080569932

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This reference is a volume in the Handbook of Physiology, co-published with The American Physiological Society. Growth in knowledge about the microcirculation has been explosive with the field becoming fragmented into numerous subdisciplines and subspecialties. This volume pulls all of the critical information into one volume. Meticulously edited and reviewed. Benefit: Provides investigators a unique tool to explore the significance of their findings in the context of other aspects of the microcirculation. In this way, the updated edition has a direct role in helping to develop new pathways of research and scholarship Highlights the explosive growth in knowledge about the microcirculation including the biology of nitric oxide synthase (NOS), endothelial cell signaling, angiogenesis, cell adhesion molecules, lymphocyte trafficking, ion channels and receptors, and propagated vasomotor responses. Benefit: Microcirculatory biology has become fragmented into numerous sub-disciplines and subspecialties, and these reference reintegrates the information in one volume

Make Life Visible

Author: Yoshiaki Toyama

Publisher: Springer Nature

Published: 2019-10-02

Total Pages: 292

ISBN-13: 9811379084

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This open access book describes marked advances in imaging technology that have enabled the visualization of phenomena in ways formerly believed to be completelyimpossible. These technologies have made major contributions to the elucidation of the pathology of diseases as well as to their diagnosis and therapy. The volume presents various studies from molecular imaging to clinical imaging. It also focuses on innovative, creative, advanced research that gives full play to imaging technology inthe broad sense, while exploring cross-disciplinary areas in which individual research fields interact and pursuing the development of new techniques where they fuse together. The book is separated into three parts, the first of which addresses the topic of visualizing and controlling molecules for life. Th e second part is devoted to imaging of disease mechanisms, while the final part comprises studies on the application of imaging technologies to diagnosis and therapy. Th e book contains the proceedings of the 12th Uehara International Symposium 2017, “Make Life Visible” sponsored by the Uehara Memorial Foundation and held from June 12 to 14, 2017. It is written by leading scientists in the field and is an open access publication under a CC BY 4.0 license.

Pathology and Pathogenesis of Human Viral Disease

Author: John E. Craighead

Publisher: Academic Press

Published: 2000-03-15

Total Pages: 466

ISBN-13: 0080538487

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Pathology and Pathogenesis of Human Viral Disease is a comprehensive reference that examines virus-induced clinical disease of humans in the context of the responsible virus and its epidemiology. Encompassing everything from cold and flu viruses to sexually transmitted diseases, this important resource describes the cellular and tissue pathological changes attributable to infection in the context of the pathogenic mechanisms involved. The author provides a comprehensive review of the older and contemporary literature, considering both the common and much rarer complications of infection. Pathology and Pathogenesis of Human Viral Disease is written from the unique perspective of the clinical pathologist. It will help clinicians and pathologists gain a better understanding of changes that occur in viral infected cells, tissues, and organs. It will also serve as a pathology source book for virologists, internists, and pediatricians. Provides a comprehensive, worldwide perspective of viral disease pathology Bridges the fields of pathology and virology; integrating clinical disease with cell and tissue pathology Addresses topics from the perspective of the clinical pathologist Illustrates unique, viral induced pathological lesions Considers common and uncommon complications of infection

Practical Immunodermatology

Author: Xing-Hua Gao

Publisher: Springer

Published: 2016-12-23

Total Pages: 385

ISBN-13: 9402409025

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This book discusses typical skin diseases from an immunological point of view, introducing the latest immunological techniques and practices. It begins with a brief overview of the human immune system, including the basic concepts and principles as well as the general symbols used in immunology. Part Two describes the human skin as an integral part of the immune system, explaining the immunological roles of major cellular and molecular composites in the skin. Part Three illustrates typical skin diseases that have immunological involvement (immunodermatological conditions). It describes 40 skin diseases, focusing on immunological causes, pathogenesis, pattern of reaction and treatment choices and responses. The final part discusses advanced immunodiagnostics and immunotherapy in dermatology, providing detailed descriptions of immune techniques for the diagnosis of skin diseases, their principles and background, indications, requirements for sampling, test protocols, interpretation of results and trouble shooting. This work offers insights into both the systemic immune system and the skin immune system, and integrates the information into discussions of clinical diseases, relevant immune techniques and immunological drugs. Presenting the latest advances in clinical immunology, it is an invaluable resource for dermatologists, residents and graduate students in dermatology.

Clinical and Basic Immunodermatology

Author: Anthony Gaspari

Publisher: Springer Science & Business Media

Published: 2008-11-05

Total Pages: 812

ISBN-13: 1848001657

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Dermatologists are being asked to understand the pathophysiology of a number of immune-mediated skin diseases. In addition, a number of new products have appeared on the market during the past decade which requires an understanding of the mechanisms of action of these drugs. Dermatologists, however, have no easily understood book to which they can refer to regarding the disease or the drug.

Migration and Homing of Lymphoid Cells

Author: Alan J. Husband

Publisher: CRC Press

Published: 2020-08-26

Total Pages: 201

ISBN-13: 1000694402

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First published in 1988: This comprehensive set is crucial to the basic understanding of the immune system and is an essential component of the design and implementation of improved immunization strategies. Contains authoritative reviews of cell migration research and addresses the is-sues of lymphocyte recirculation leading to inductive interactions, and the subsequent migration and homing of effector cells generated from these responses. Systemic migration of cells from the central and peripheral lymphoid organs, the dichotomy of behavior between systemic and mucosal lymphoid cell pools, and explanations sought for mechanisms mediating selectivity of migration and homing are covered. This set is of interest to problem oriented scientists.

Lymphocyte Updates

Author: Gheorghita Isvoranu

Publisher: BoD – Books on Demand

Published: 2017-07-12

Total Pages: 194

ISBN-13: 9535133438

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This book represents a synergic effort of an international team of specialists in immunology to expand the scientific achievements in the field of lymphocytes. It offers important and specific updated information to researchers, students, teachers, and medical professionals. Moreover, considering the remarkable dynamics of immunology and immunotherapy, this book "Lymphocyte Updates - Cancer, Autoimmunity, and Infection" aims to represent a significant source of concise scientific data and advancement of knowledge in this field. The chapters offer new insights into the latest scientific progress on lymphocyte roles in protective immunity, as well as their involvement in pathogenesis of various disorders.

Mucosal Vaccines

Author: Hiroshi Kiyono

Publisher: Elsevier

Published: 1996-10-23

Total Pages: 501

ISBN-13: 0080537057

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This comprehensive, authoritative treatise covers all aspects of mucosal vaccines including their development, mechanisms of action, molecular/cellular aspects, and practical applications. The contributing authors and editors of this one-of-a-kind book are very well known in their respective fields. Mucosal Vaccines is organized in a unique format in which basic, clinical, and practical aspects of the mucosal immune system for vaccine development are described and discussed. This project is endorsed by the Society for Mucosal Immunology. Provides the latest views on mucosal vaccines Applies basic principles to the development of new vaccines Links basic, clinical, and practical aspects of mucosal vaccines to different infectious diseases Unique and user-friendly organization