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Lung Biology and Pathophysiology

Author: Yutong Zhao

Publisher: CRC Press

Published: 2024-02-20

Total Pages: 436

ISBN-13: 1003833284

The lungs are the organ for gas exchange between the body and the external environment. Dysfunction of upper airway epithelium and smooth muscle cells leads to pathogenesis of asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, and other conditions, resulting in airway inflammation and narrowing. Injury to alveolar epithelium and endothelium causes influx of neutrophil and protein-rich fluid from circulation, resulting in edema and disruption of gas exchange. In addition to lung structural cells, immune cells, including alveolar macrophages and lymphocytes play critical roles in the maintenance of lung function. This book contributes to the understanding homeostasis of lung cells in the physiological and pathological conditions critical to the development of novel therapeutics. Key Features Highlights the role the lungs play as an interface between the body and the environment Describes the underlying mechanism of lung diseases Emphasizes the ways nutrition contributes to lung health as well as the ways pollution adversely affect lung function Includes contributions from leading researchers Chapters 8 and 13 of this book are available for free in PDF format as Open Access from the individual product page at www.routledge.com. It has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.

Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease

Author: Venkataramana K Sidhaye

Publisher: Academic Press

Published: 2017-03-09

Total Pages: 277

ISBN-13: 0128038810

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Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease. The book provides access to knowledge of molecular and cellular aspects of lung homeostasis and repair, including the molecular basis of lung epithelial intercellular communication and lung epithelial channels and transporters. Also included is coverage of lung epithelial biology as it relates to fluid balance, basic ion/fluid molecular processes, and human disease. Useful to physician and clinical scientists, the contents of this book compile the important and most current findings about the role of epithelial cells in lung disease. Medical and graduate students, postdoctoral and clinical fellows, as well as clinicians interested in the mechanistic basis for lung disease will benefit from the books examination of principles of lung epithelium functions in physiological condition. Provides a single source of information on lung epithelial junctions and transporters Discusses of the role of the epithelium in lung homeostasis and disease Includes capsule summaries of main conclusions as well as highlights of future directions in the field Covers the mechanistic basis for lung disease for a range of audiences

Comparative Biology of the Normal Lung

Author: Richard A. Parent

Publisher: Academic Press

Published: 2015-03-13

Total Pages: 835

ISBN-13: 0124047262

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Comparative Biology of the Normal Lung, Second Edition, offers a rigorous and comprehensive reference for all those involved in pulmonary research. This fully updated work is divided into sections on anatomy and morphology, physiology, biochemistry, and immunological response. It continues to provide a unique comparative perspective on the mammalian lung. This edition includes several new chapters and expanded content, including aging and development of the normal lung, mechanical properties of the lung, genetic polymorphisms, the comparative effect of stress of pulmonary immune function, oxygen signaling in the mammalian lung and much more. By addressing scientific advances and critical issues in lung research, this 2nd edition is a timely and valuable work on comparative data for the interpretation of studies of animal models as compared to the human lung. Edited and authored by experts in the field to provide an excellent and timely review of cross-species comparisons that will help you interpret and compare data from animal studies to human findings Incorporates lung anatomy and physiology, cell specific interactions and immunological responses to provide you with a single and unique multidisciplinary source on the comparative biology of the normal lung Includes new and expanded content on neonatal and aged lungs, developmental processes, cell signaling, antioxidants, airway cells, safety pharmacology and much more Section IV on Physical and Immunological Defenses has been significantly updated with 9 new chapters and an increased focus on the pulmonary immunological system

How Tobacco Smoke Causes Disease

Author: United States. Public Health Service. Office of the Surgeon General

Publisher:

Published: 2010

Total Pages: 728

ISBN-13:

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This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Lung Injury

Author: Robert H. Notter

Publisher: CRC Press

Published: 2005-04-20

Total Pages: 888

ISBN-13: 9781135521981

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Progressing from general scientific principles and concepts to in-depth topical discussions of current research and treatment methods, this comprehensive reference defines the cellular and molecular mechanisms contributing to inflammatory lung injury and repair. Extensive coverage is provided on key mediators and pathways important in acute and chronic pulmonary inflammation and lung injury, as well as the mechanistic pathophysiology of related diseases ranging from clinical acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) to idiopathic pulmonary fibrosis (IPF) and other subacute and chronic conditions. Additional chapters also address vascular dysfunction, surfactant dysfunction, reactive oxygen/nitrogen species, and cell and animal models of acute and chronic lung injury.

Pharmacology and Pathophysiology of the Control of Breathing

Author: Denham S. Ward

Publisher: CRC Press

Published: 2005-05-24

Total Pages: 888

ISBN-13: 9780824758905

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Exploring the functional anatomy and physiology of the ventilatory control system from the intracellular to the integrative level, this references serves as the first source to offer comprehensive coverage of the influences of various pharmacological agents on the control of breathing.

Pathophysiology and Treatment of Inhalation Injuries

Author: J. Loke

Publisher: CRC Press

Published: 2020-11-25

Total Pages: 586

ISBN-13: 1000147002

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This book covers several aspects of inhalation toxicology ranging from inhalation drug abuse to battlefield chemical inhalation lung injury, and emphasizes pathophysiology and therapy.

Pathology of Lung Disease

Author: Helmut Popper

Publisher: Springer

Published: 2016-12-22

Total Pages: 708

ISBN-13: 366250491X

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This well-illustrated textbook covers the full range of lung and pleural diseases from the pathologic standpoint. Both diseases of adults and pediatric lung diseases are presented. The book will serve as an excellent guide to the diagnosis of these diseases, but in addition it explains the disease mechanisms and etiology. Genetics and molecular biology are also discussed whenever necessary for a full understanding. The author is an internationally recognized expert who runs courses on lung and pleural pathology attended by participants from all over the world. In compiling this book, he has drawn on more than 30 years’ experience in the field.

Spencer's Pathology of the Lung

Author: Philip Hasleton

Publisher: Cambridge University Press

Published: 2013-01-17

Total Pages: 4616

ISBN-13: 1139618970

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Fully rewritten and updated for the cutting-edge sixth edition, Spencer's Pathology of the Lung follows in its predecessors' footsteps as the gold-standard textbook of pulmonary diseases. All recognized diseases of the lungs are discussed and illustrated with extensive, high-quality color images. Each chapter includes practical, clear and concise diagnostic features, including immunohistochemistry, molecular tests and differential diagnoses, while rare entities are discussed and illustrated in detail. This thoroughly reworked edition includes new classification schemes and the latest understanding of the pathophysiology and molecular aspects of a wide range of diseases. Non-neoplastic diseases are presented according to epidemiology, genetics, clinical manifestations, radiographic findings, pathology, cytology, laboratory findings, pathogenesis, differential diagnosis, prognosis and natural history. Neoplasms are discussed according to cell or origin with sections devoted to genetics, molecular findings and clinicopathologic correlations. Downloadable versions of all images are available on a CD-ROM packaged with the print book. Written and edited by leading experts in the field, this is an essential resource for practising and trainee pathologists.

Lung Surfactants

Author: Robert H. Notter

Publisher: CRC Press

Published: 2000-07-18

Total Pages: 476

ISBN-13: 9780824704018

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Integrating basic and clinical research on the biophysical and physiological functions of pulmonary surfactants, this practical reference presents thorough, cutting-edge coverage on surfactant-related lung disease. Manage neonatal respiratory distress syndrome (RDS), acute respiratory distress syndrome (ARDS), and acute lung injury more effectively!