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Loss and Restoration of Regenerative Capacity in Tissues and Organs of Animals

Author: Lev Vladimirovich Polezhaev

Publisher: Harvard University Press

Published: 1972

Total Pages: 406

ISBN-13: 9780674539204

This well-illustrated monograph is the first summary in English of L.V. Polezhaev's important but lesser known work on the regenerative phenomena in mammalian forms, conducted since World War II. During this period Soviet research underwent a pronounced shift in emphasis from basic biological studies based primarily upon amphibians to more practically oriented problems in mammalian systems. Polezhaev's experimentation underwent a corresponding shift, but the focus on restoration of lost regenerative capacity was retained since his earlier work, which is also reviewed here, on limb regeneration in frogs. Following a theoretical discussion, the monograph centers upon the author's most profound innovations: a successful method for producing bone to heal large skull defects, original research on heart regeneration, and trials in the restoration of limb regeneration following X-irradiation.

Introduction to Epigenetics

Author: Renato Paro

Publisher: Springer Nature

Published: 2021-03-23

Total Pages: 215

ISBN-13: 3030686701

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This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease

Vertebrate Regeneration

Author: Charles Stead Thornton

Publisher:

Published: 1973

Total Pages: 538

ISBN-13:

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Epigenetics and Regeneration

Author:

Publisher: Academic Press

Published: 2019-05-24

Total Pages: 541

ISBN-13: 0128148802

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Epigenetics and Regeneration compiles the first foundational reference on epigenetic mechanisms governing tissue development, repair, homeostasis, and regeneration, as well as pathways to employ these mechanisms in clinical practice and translational science. In this book, life science researchers, clinicians, and students will discover an interdisciplinary resource bringing together common themes in the field, background overviews, research methods, recent advances, and opportunities for drug discovery. Throughout this volume, special attention is paid to pre-clinical and first clinical studies aimed at increasing the regenerative potential of damaged tissues by epigenetic drugs, as well as innovative, discipline spanning strategies to enhance cell reprogramming. As an all-inclusive, evidence-based volume, Epigenetics and Regeneration will stimulate discussion and boost new research in this fascinating and impactful area of translational epigenetics. Provides a foundational overview of epigenetics in regenerative medicine Examines epigenetic components of tissue regeneration for a variety of organ systems and tissue types, as well as current attempts to employ these mechanisms in clinical practice Offers researchers, students, clinicians, and pharmacologists the tools they need to enhance tissue development, repair, homeostasis, and regeneration and explore new epigenetic therapeutic pathways Features chapter contributions from leading international researchers and clinicians in the fields of epigenetics and regenerative medicine

Organ Regeneration in Animals

Author: Lev Vladimirovich Polezhaev

Publisher: Charles C. Thomas Publisher

Published: 1972

Total Pages: 208

ISBN-13:

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Principles of Regenerative Biology

Author: Bruce M. Carlson

Publisher: Elsevier

Published: 2011-10-10

Total Pages: 400

ISBN-13: 9780080477961

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With the explosion of knowledge from molecular biology and the burgeoning interest in generating or regenerating tissues or organs through various bioengineering or stem cell approaches, many scientists and students have shown a renewed interest in the phenomenon of regeneration. Because relatively few have had the luxury of being able to approach the phenomenon of regeneration from a broad biological perspective, Dr. Carlson has produced a book that outlines the fundamental principles of regeneration biology. Subject matters focus principally on regeneration in vertebrate systems, but also invertebrate regeneration. In order to manipulate regenerative processes, it is important to understand the underlying principles of regeneration. Principles of Regnerative Biology is the key introductory reference for all developmental biologists, geneticists, and tissue and stem cell researchers. Creates a general understanding of one of the most fascinating and complex phenomena in biology Discusses the ability and diversity of regeneration in various organisms Explains the history and origins of cells in regenerating systems Includes information on stem cells and its important role in regeneration

Methods in Mammalian Reproduction

Author: Joseph C. Jr. Daniel

Publisher: Elsevier

Published: 2012-12-02

Total Pages: 586

ISBN-13: 0323145205

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Methods in Mammalian Reproduction presents some of the techniques for manipulating, analyzing, observing, testing, and generally experimenting with mammalian mothers and their gametes and embryos. Mammalian reproduction involves an intimate relationship between mother and embryo. The first 18 chapters are arranged in an order that follows a developmental sequence from oocyte to fetal organs and the remaining seven chapters deal with the maternal side of the relationship. With strong focus on laboratory rodents and lagomorphs, the book starts with an introduction to in vitro oocyte maturation and experimental production of mammalian parthenogenetic. It goes on to describe the microtechniques in pre-implantation of embryos, production of chimeras, techniques for early embryonic tissue separation, mammalian embryo preservation by freezing, and in vitro development of whole mouse embryos beyond the implantation stage. Chapters 11-15 discuss the in vitro implantation of mouse blastocysts, advances in rabbit embryo and in large mammal embryo cultures, embryo transfer in large domestic mammals, and manipulation of marsupial embryos and pouch young. The following chapters cover reproduction experiments using marsupials, domestic farm species, and primates including humans. Finally, the concluding chapters tackle the use of amniocentesis in prenatal diagnosis, collection and analysis of female genital tract secretions, analysis of antifertility action of intrauterine devices, and surgical induction of endometriosis. This book will be helpful to students, teachers, researchers, and clinical researchers who demand for more and better procedures for analysis of mammalian reproduction.

Planarian Regeneration

Author: Jochen C. Rink

Publisher: Humana

Published: 2018-06-19

Total Pages: 0

ISBN-13: 9781493978007

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This volume explores the various facets of planaria as a biomedical model system and discusses techniques used to study the fascinating biology of these animals. The chapters in this book are divided into two parts: Part One looks at the biodiversity of planarian species, the molecular orchestration of regeneration, ecology of planarians in their natural habitats and their history as lab models. Part Two talks about experimental protocols for studying planarians, ranging from the establishment of a planarian research colony, to RNA and DNA extraction techniques, all the way to single stem cell transplantations or metabolomics analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Planarian Regeneration: Methods and Protocols is a valuable resource for both newcomers to the field and experts within established planarian laboratories.

The Physiology of Bioelectricity in Development, Tissue Regeneration and Cancer

Author: Christine E. Pullar

Publisher: CRC Press

Published: 2016-04-19

Total Pages: 308

ISBN-13: 1439837244

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Recent advances in technology have led to the unprecedented accuracy in measurements of endogenous electric fields around sites of tissue disruption. State-of-the-art molecular approaches demonstrate the role of bioelectricity in the directionality and speed of cell migration, proliferation, apoptosis, differentiation, and orientation. New informat

Radiation Biology

Author: Donald J. Pizzarello

Publisher: CRC Press

Published: 2020-04-15

Total Pages: 480

ISBN-13: 1000696499

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First Published in 1991, this book offers a full, comprehensive guide into the aspects of radiation and how it affects our bodies. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for Students of Radiology, and other practitioners in their respective fields.