Liver Transplantation - ECAB

Liver Transplantation - ECAB PDF

Author:

Publisher: Elsevier Health Sciences

Published: 2013-01-10

Total Pages: 209

ISBN-13: 8131232476

DOWNLOAD EBOOK →

Liver Transplantation (LT), until recently the ‘forbidden fruit’, is the newest, the sexiest, the most controversial and arguably, the most technically challenging subspecialty of Surgical Gastroenterology to have mushroomed in India. In a journey spanning 12 years, 28 centers and 1500 liver transplants, we imagined there would be a gripping story to tell. It was only appropriate then, that we chose to inaugurate the series with an overview of Liver Transplantation. In the last 2 decades, the field has seen rapid progress with 1- and 5-year patient survival improving from 80% and 50% to 90% and 80%, respectively, owing to technical refinement, and better immunosuppressants, intensive care, and patient monitoring. Despite being a relatively new entrant into the field, India can now boast of at least some islands of excellence that have caught up with the "best in the west". This means the evolution of LT in these centers has been fast-forwarded up a steep curve. We have come a long way from the point of every LT being considered an experimental procedure with much media and public hype to one where it is accepted as a successful and durable panacea for all liver failure. The popularity of teams running successful programs in India has swung from being ostracized when the chips were down, to being celebrated and envied when the going became good. The focus has shifted from immediate to long-term survival, from surgical heroism to building multidisciplinary teams, from anecdotal to hard data and from media reports to scientific publications. ‘Fly-by night’ operations are on the decline as realization of their futility dawns on new centers and transplant teams. They are now happier to take the longer route of developing trained in-house teams. After spending a good part of the last decade honing the technique of living donor liver transplantation, we are becoming more sensitive to the morbidity and mortality risks to the living liver donor. We want to minimize the liver volume removed from the donor, and want to develop techniques of minimal access. More importantly, we want to train our guns back on pushing donation after brain or cardiac death. We have begun to maintain databases, are getting into audit mode and want a National registry. We want standardized treatment guidelines and training curricula. We want to take part in multicenter trials and further meaningful clinical and laboratory research. As a community, the liver transplant doctors of India are on a warpath of progress. We want it all and we want it now! The first step to the march into the future is to size up the past and the present. That is what we have attempted to do in this volume.

Renal Transplant - ECAB

Renal Transplant - ECAB PDF

Author: Vijay Kher

Publisher: Elsevier Health Sciences

Published: 2013-01-10

Total Pages: 259

ISBN-13: 813123200X

DOWNLOAD EBOOK →

Kidney transplantation is one of the breakthroughs in medical science. The most important consideration in the procedure is the natural tendency of the human immune system to reject any foreign tissue—be it a harmful bacteria or a life-saving kidney. After transplantation, the immune system of the patient will reject the kidney in no time. The answer to the solution has been the tremendous development in the identification and use of immunosuppressive medicines. But on the other hand, as we reduce the strength of immune system, the patients are highly prone to infections and it can cause life-threatening infections if left undiagnosed. So, the greatest job of the nephrologist is to balance the immune system to a level where the kidneys are not rejected and at the same time keep the immune system at a level where the infections are kept under control. This is akin to walking on a tight rope. The last few years witnessed significant improvisations in kidney transplantation—the introduction of newer immunosuppressive drugs to increase the success rates of transplantation; steps to increase the donor availability (by doing ABO incompatible transplantation and by performing transplants from non-heart beating donors); and lastly, kidney removal from the donor through laparoscopic donor nephrectomy. This book focuses on the various aspects of choosing the donor, to donor nephrectomy, the outpatient care of the donor and the recipient and also the legal and ethical issues related to the same.

Alcoholic Liver Disease - ECAB

Alcoholic Liver Disease - ECAB PDF

Author: Philip Abraham

Publisher: Elsevier Health Sciences

Published: 2009-09-15

Total Pages: 168

ISBN-13: 8131231844

DOWNLOAD EBOOK →

Alcoholic liver disease involves an acute or chronic inflammation of liver occurring as a consequence of alcohol abuse. The pathological changes occur in 3 stages namely, fatty liver, alcoholic liver disease and cirrhosis, with the final stage traditionally considered to be irreversible. Alcoholic liver disease is responsible for a significant number of premature deaths per annum all around the globe. There is an urgent need to educate the masses about the hazards of alcohol abuse. An efficient system to encourage and prolong the period of alcohol abstinence is the need of the hour. The importance of lifestyle modifications like weight reduction and cessation of smoking in the progression of liver disease needs to be communicated to the patients and the medical community as well. Moreover, realization of the role of nutrition in the management and recovery of ALD would enhance the treatment strategies for this condition. This book has been designed to update the readers on the important aspects of ALD and is a step forward to enable the society in combating the social and economic losses that occur as a result of alcohol abuse. The book has stressed upon various aspects of ALD like the role of nutrition, epidemiology and pathogenesis, and the possible therapeutic strategies involved. Supportive case scenarios have also been incorporated with relevance to the topics covered under the book. Overall, the book presents to the readers an excellent compilation of clinically applicable literature sourced from the most acclaimed physicians in the country.

Hepatic Encephalopathy - ECAB

Hepatic Encephalopathy - ECAB PDF

Author: Prabha Sawant

Publisher: Elsevier Health Sciences

Published: 2013-06-17

Total Pages: 104

ISBN-13: 8131231836

DOWNLOAD EBOOK →

Hepatic encephalopathy is the clinical syndrome resulting from increased ammonia levels in blood. The most common cause of HE is chronic liver disease. However, acute liver failure, Reye’s syndrome, or metabolic defects are other causes. The true prevalence of overt HE is difficult to establish because of the considerable heterogeneity in etiology and disease severity. However, HE has been reported to be present in around 50% of patients with cirrhosis or with porto-caval shunts at some time during their illness. It is less common in patients with portosystemic shunts without liver disease. Thirty percent of patients dying of end-stage liver disease experience significant encephalopathy, approaching coma. After TIPS placement, approximately 1/3 of patients will experience overt HE. Minimal HE (MHE) is difficult to diagnose due to lack of standard diagnostic tests. Its clinical significance with regards to progression to overt encephalopathy has however, not been established. Conventional treatment of hepatic encephalopathy relies primarily on reducing the production and absorption of ammonia. Identification and correction of the precipitating factors and general supportive measures are important management steps. There are very few randomized controlled trials (RCT) of therapies and even these are bugged by lack of a control group and small sample sizes.