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Life During a Golden Age of Peptide Chemistry

Author: Bruce Merrifield

Publisher:

Published: 1993

Total Pages: 328

ISBN-13:

Thirteenth in a series of autobiographies of 22 eminent organic chemists, the present volume chronicles the life and contributions to the field of Bruce Merrifield, winner of the 1984 Nobel Prize for chemistry. Subtitled The Concept and Development of Solid-Phase Peptide Synthesis. Highly illustrated with diagrams, tables, graphs and (bandw) photographs. Annotation copyright by Book News, Inc., Portland, OR

An Appreciation of the Scientific Life and Acheivements of Bruce Merrifield

Author:

Publisher:

Published: 2007

Total Pages: 5

ISBN-13:

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Bruce Merrifield's scientific biography, 'Life During a Golden Age of Peptide Chemistry: The Concept and Development of Solid-Phase Peptide Synthesis', provides a history of solid phase-peptide synthesis (SPPS) from 1959 to 1993 [1]. While many readers will be familiar with SPPS literature after 1963, the inclusion of unpublished material from Merrifield's early laboratory notebooks opens a fascinating window on the development of SPPS from the formulation of concept in 1959 (p. 56, ref. 1) to the synthesis of a tetrapeptide four years later [2]. This early period was characterized by slow progress interrupted by numerous setbacks that led Bruce to later record (p. 90, ref. 1): 'At the end of the first two years the results were so poor, I wonder what made me think that this approach would ever succeed; but from the outset I had a strong conviction that this was a good idea, and I am glad that I stayed with it long enough'. Garland Marshall, Bruce's first graduate student (1963-1966), as well as later colleagues, were essentially unaware of the many highways, byways and dead ends that Bruce had explored in the early years [3].

The World of Peptides

Author: Theodor Wieland

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 311

ISBN-13: 3642758509

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Almost two centuries ago proteins were recognized as the primary materials (proteios = primary) oflife, but the significance and wide role of peptides (from pepsis = digestion) in practically all life pro cesses has only become apparent in the last few decades. Biologi cally active peptides are now being discovered at rapid intervals in the brain and in other organs including the heart, in the skin of amphibians and many other tissues. Peptides and peptide-like compounds are found among toxins and antibiotics. It is unlikely that this process, an almost explosive broadening of the field, will come to a sudden halt. By now it is obvious that Nature has used the combination of a small to moderate number of amino acids to generate a great variety of agonists with specific and often highly sophisticated functions. Thus, peptide chemistry must be regarded as a discipline in its own right, a major branch of biochemistry, fairly separate from the chemistry of proteins. Because of the important role played by synthesis both in the study and in the practical preparation of peptides, their area can be considered as belonging to bio-organic chemistry as well. The already overwhelming and still increasing body of know ledge renders an account of the history of peptide chemistry more and more difficult. It appears therefore timely to look back, to take stock and to recall the important stages in the development of a new discipline.

Peptide Chemistry

Author: Miklos Bodanszky

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 207

ISBN-13: 364278206X

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A continued interest in Peptide Chemistry prompted the revision of the first edition of this book. This provided an opportunity to update several details. I am grateful to colleagues who were kind enough to inform me of errors, typographical and other, they had discovered in the first edi tion. These have now been corrected, as were certain shortcomings in language and style pointed out by my daughter, Dr. Eva Bodanszky. In 1991 the excellent The Chemical Synthesis of Peptides by John Jones (Oxford University Press, 1991) appeared. It covers, in part, the same field, but is different enough from Peptide Chemistry, to justify publication of a revised edition of the latter. Princeton, July 1993 M. Bodanszky Preface to the First Edition Nature applied peptides for a great variety of specific functions. The specificity provided by the individual character of each amino acid is further ehanced by the combination of several amino acids into larger molecules. Peptides therefore can act as chemical messengers, neuro transmitters, as highly specific stimulators and inhibitors, regulating var ious life-processes. Entire classes of biologically active compounds, such as the opioid peptides or the gastrointestinal hormones emerged within short periods of time and it is unlikely that the rapid succession of discoveries of important new peptides would come to a sudden halt. In fact, our knowledge of the field is probably still in an early stage of development. Peptides also gained importance in our everyday life.

Biographies of Scientists

Author: Roger Smith

Publisher: Scarecrow Press

Published: 1998

Total Pages: 308

ISBN-13: 9780810833845

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Provides more than 500 sources of information on scientists for young and adult general readers and for scholars. These sources explain scientists' accomplishments in the context of the personal and career developments that made those accomplishments possible

My Life in the Golden Age of Chemistry

Author: F. Albert Cotton

Publisher: Elsevier

Published: 2014-08-19

Total Pages: 513

ISBN-13: 0128013389

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A giant in the field and at times a polarizing figure, F. Albert Cotton’s contributions to inorganic chemistry and the area of transitions metals are substantial and undeniable. In his own words, My Life in the Golden Age of Chemistry: More Fun than Fun describes the late chemist’s early life and college years in Philadelphia, his graduate training and research contributions at Harvard with Geoffrey Wilkinson, and his academic career from becoming the youngest ever full professor at MIT (aged 31) to his extensive time at Texas A&M. Professor Cotton’s autobiography offers his unique perspective on the advances he and his contemporaries achieved through one of the most prolific times in modern inorganic chemistry, in research on the then-emerging field of organometallic chemistry, metallocenes, multiple bonding between transition metal atoms, NMR and ESR spectroscopy, hapticity, and more. Working during a time of generous government funding of science and strong sponsorship for good research, Professor Cotton’s experience and observations provide insight into this prolific and exciting period of chemistry. Offers personal and often wry perspective from this prominent chemist and recipient of some of science’s highest honors: the U.S. National Medal of Science (1982), the Priestley Medal (the American Chemical Society's highest recognition, 1998), membership in the U. S. National Academy of Sciences and corresponding international bodies, and 29 honorary doctorates Details the background behind the development and emergence of groundbreaking research in organometallic chemistry and transition metals Provides beautifully-written and engaging insight into a "Golden Age of Chemistry" and the work of historically renowned chemists

Amino Acids, Peptides and Proteins in Organic Chemistry, Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis

Author:

Publisher: John Wiley & Sons

Published: 2011-06-03

Total Pages: 541

ISBN-13: 3527641572

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This is the fourth of five books in the Amino Acids, Peptides and Proteins in Organic Synthesis series. Closing a gap in the literature, this is the only series to cover this important topic in organic and biochemistry. Drawing upon the combined expertise of the international "who's who" in amino acid research, these volumes represent a real benchmark for amino acid chemistry, providing a comprehensive discussion of the occurrence, uses and applications of amino acids and, by extension, their polymeric forms, peptides and proteins. The practical value of each volume is heightened by the inclusion of experimental procedures. The 5 volumes cover the following topics: Volume 1: Origins and Synthesis of Amino Acids Volume 2: Modified Amino Acids, Organocatalysis and Enzymes Volume 3: Building Blocks, Catalysis and Coupling Chemistry Volume 4: Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis Volume 5: Analysis and Function of Amino Acids and Peptides The fourth volume in this series is structured in three main sections. The first section is about protection reactions and amino acid based peptidomimetics. The second, and most extensive, part is devoted to the medicinal chemistry of amino acids. It includes, among others, the chemistry of alpha- and beta amino acids, peptide drugs, and advances in N- and O-glycopeptide synthesis. The final part deals with amino acids in combinatorial synthesis. Methods, such as phage display, library peptide synthesis, and computational design are described. Originally planned as a six volume series, Amino Acids, Peptides and Proteins in Organic Chemistry now completes with five volumes but remains comprehensive in both scope and coverage. Further information about the 5 Volume Set and purchasing details can be viewed here.

Peptides for Youth

Author: Susan Valle

Publisher: Springer Science & Business Media

Published: 2009-06-23

Total Pages: 703

ISBN-13: 0387736573

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The American Peptide Society (APS) provides a forum for advancing and promoting knowledge of the chemistry and biology of peptides. The approximately one thousand members of the Society come from North America and from more than thirty other countries throughout the world. Establishment of the APS was a result of the rapid worldwide growth that has occurred in peptide-related research, and of the increasing interaction of peptide scientists with virtually all fields of science. Peptides for Youth: The Proceedings of the the 20th American Peptide Symposium will highlight many of the recent developments in peptide science, with a particular emphasis on how these advances are being applied to basic problems in biology and medicine. The 20th American Peptide Symposium will take place June 26 - 30, 2007 in Montreal, Canada.

Peptide Synthesis and Applications

Author: John Howl

Publisher: Springer Science & Business Media

Published: 2008-02-02

Total Pages: 263

ISBN-13: 1592598773

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Hands-on experts describe in step-by-step detail the key methodologies of contemporary peptide synthesis and illustrate their numerous applications. The techniques presented include protocols for chemical ligation, the synthesis of cyclic and phosphotyrosine-containing peptides, lipoamino acid- and sugar-conjugated peptides, and peptide purification and analyses. Additional chapters detail methodologies and instrumentation for high-throughput peptide synthesis, many different applications of peptides as novel research tools and biological probes, and the design and application of fluorescent substrate-based peptides that can be used to determine the selectivity and activity of peptidases. A practical guide to the identification of proteins using mass spectrometric analyses of peptide mixtures is also included.

High-Throughput Synthesis

Author: Irving Sucholeiki

Publisher: CRC Press

Published: 2001-02-22

Total Pages: 398

ISBN-13: 9781420056518

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An exploration of high-throughput synthesis, this book presents a compilation of how-to methods, novel materials, and catalyst developments for creating a multitude of new compounds. Introductory sections are coupled with in-depth case studies clarifying theory through practice. The book emphasizes the potential for reproducing experiments in detail.