Laughing Gas, Viagra, and Lipitor

Laughing Gas, Viagra, and Lipitor PDF

Author: Jie Jack Li

Publisher: Oxford University Press

Published: 2006-09-07

Total Pages: 336

ISBN-13: 0199885281

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The stories behind drug discovery are fascinating, full of human and scientific interest. This is a book on the history of drug discovery that highlights the intellectual splendor of discoverers as well as the human frailty associated them. History is replete with examples of breakthrough medicines that have saved millions of lives. Ether as an anesthetic by Morton; penicillin as an antibiotic by Fleming; and insulin as an anti-diabetic by Banting are just a few examples. The discoverers of these medicines are doubtlessly benefactors to mankind--for instance, without penicillin, 75% of us probably would not be alive because some of our parents or grandparents would have succumbed to infections. Dr. Jack Li, a medicinal chemist who is intimately involved with drug discovery, has assembled an astounding amount of facts and information behind important drugs through extensive literature research and interviews with many inventors of the drugs including Viagra and Lipitor. There have been many myths and inaccuracies associated with those legendary drugs. The inventors perspectives afforded this book an invaluable accuracy and insight because history is not history unless it is true. The text is supplemented by many anecdotes, pictures and postage stamps. Both specialist and layman will find Laughing Gas, Viagra, and Lipitor informative and entertaining. Students in chemistry, pharmacy, and medicine, workers in healthcare and high school science teachers will find this book most useful.

Laughing Gas, Viagra, and Lipitor

Laughing Gas, Viagra, and Lipitor PDF

Author: Jie Jack Li

Publisher: Oxford University Press

Published: 2006-09-07

Total Pages: 336

ISBN-13: 9780195345766

DOWNLOAD EBOOK →

The stories behind drug discovery are fascinating, full of human and scientific interest. This is a book on the history of drug discovery that highlights the intellectual splendor of discoverers as well as the human frailty associated them. History is replete with examples of breakthrough medicines that have saved millions of lives. Ether as an anesthetic by Morton; penicillin as an antibiotic by Fleming; and insulin as an anti-diabetic by Banting are just a few examples. The discoverers of these medicines are doubtlessly benefactors to mankind--for instance, without penicillin, 75% of us probably would not be alive because some of our parents or grandparents would have succumbed to infections. Dr. Jack Li, a medicinal chemist who is intimately involved with drug discovery, has assembled an astounding amount of facts and information behind important drugs through extensive literature research and interviews with many inventors of the drugs including Viagra and Lipitor. There have been many myths and inaccuracies associated with those legendary drugs. The inventors perspectives afforded this book an invaluable accuracy and insight because history is not history unless it is true. The text is supplemented by many anecdotes, pictures and postage stamps. Both specialist and layman will find Laughing Gas, Viagra, and Lipitor informative and entertaining. Students in chemistry, pharmacy, and medicine, workers in healthcare and high school science teachers will find this book most useful.

Top Drugs

Top Drugs PDF

Author: Jie Jack Li

Publisher: Oxford University Press

Published: 2015-07-31

Total Pages: 240

ISBN-13: 0199362599

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Drugs like Lipitor, Plavix, Taxol, and Zoloft are integral in today's medicinal world. These widely used products save lives and improve the quality of lives, playing a crucial role in everything from cholesterol management to cancer treatment. These advances in medicine were brought into existence after nuanced process of creation, featuring a wide range of chemical and pharmacological experimentation and discovery. Top Drugs: Their History, Pharmacology, and Synthesis provides an in-depth study on ten prominent drugs, outlining the chemistry behind each one's creation. Jie Jack Li, a medicinal chemist and an expert on drug discovery, offers a thorough analysis of the landscape of current drug development. The comprehensive text is divided by health issues, including cardiovascular, cancer, metabolic diseases, and infectious diseases. Each section features individual chapters on significant drugs, outlining the chemistry and history of the drug's discovery. Li begins each chapter with the product's history, providing necessary context. Li then proceeds to describe the mechanism of action, structure-activity relationship (SAR), bioavailability, metabolism, toxicology, the discovery route, and the process route. Top Drugs: Their History, Pharmacology, and Synthesis will acclimate students, scientists, and interested laypersons to the world of chemistry and drug discovery.

Triumph of the Heart

Triumph of the Heart PDF

Author: Jie Jack Li

Publisher: OUP USA

Published: 2009-04-03

Total Pages: 220

ISBN-13: 0195323572

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Prologue. 1. Cholesterol. 2. Genesis of Statins. 3. Merck's Triumph. 4. Discovery of Lipitor. 5. Development of Lipitor. 6. To Market, To Market. 7. Baycol, Crestor, and Drugs beyond Statins. 8. Reflections. Appendix. Trademarks of the Drugs. Bibliography and Notes. Index.

Blockbuster Drugs

Blockbuster Drugs PDF

Author: Jie Jack Li

Publisher: Oxford University Press

Published: 2014

Total Pages: 238

ISBN-13: 0199737681

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"This book uses the cases of several landmark drugs to discuss the history of the pharmaceutical industry, and discusses what could be next"--Provided by publisher.

The SAGE Encyclopedia of Economics and Society

The SAGE Encyclopedia of Economics and Society PDF

Author: Frederick F. Wherry

Publisher: SAGE Publications

Published: 2015-09-01

Total Pages: 1984

ISBN-13: 150630088X

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Economics is the nexus and engine that runs society, affecting societal well-being, raising standards of living when economies prosper or lowering citizens through class structures when economies perform poorly. Our society only has to witness the booms and busts of the past decade to see how economics profoundly affects the cores of societies around the world. From a household budget to international trade, economics ranges from the micro- to the macro-level. It relates to a breadth of social science disciplines that help describe the content of the proposed encyclopedia, which will explicitly approach economics through varied disciplinary lenses. Although there are encyclopedias of covering economics (especially classic economic theory and history), the SAGE Encyclopedia of Economics and Society emphasizes the contemporary world, contemporary issues, and society. Features: 4 volumes with approximately 800 signed articles ranging from 1,000 to 5,000 words each are presented in a choice of print or electronic editions Organized A-to-Z with a thematic Reader's Guide in the front matter groups related entries Articles conclude with References & Future Readings to guide students to the next step on their research journeys Cross-references between and among articles combine with a thorough Index and the Reader's Guide to enhance search-and-browse in the electronic version Pedagogical elements include a Chronology of Economics and Society, Resource Guide, and Glossary This academic, multi-author reference work will serve as a general, non-technical resource for students and researchers within social science programs who seek to better understand economics through a contemporary lens.

Lecture Notes in Real Analysis

Lecture Notes in Real Analysis PDF

Author: Xiaochang Wang

Publisher: Springer

Published: 2018-11-21

Total Pages: 207

ISBN-13: 3319989561

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This compact textbook is a collection of the author’s lecture notes for a two-semester graduate-level real analysis course. While the material covered is standard, the author’s approach is unique in that it combines elements from both Royden’s and Folland’s classic texts to provide a more concise and intuitive presentation. Illustrations, examples, and exercises are included that present Lebesgue integrals, measure theory, and topological spaces in an original and more accessible way, making difficult concepts easier for students to understand. This text can be used as a supplementary resource or for individual study.

Good Chemistry

Good Chemistry PDF

Author: Alex Baenninger

Publisher: McGraw Hill Professional

Published: 2004

Total Pages: 200

ISBN-13: 9780071426176

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The development of Valium by Roche Pharmaceutical and the entire benzodiazepine group of active substances was among the greatest accomplishments in 20th-century pharmacology. Good Chemistry combines a detailed account of this momentous development with an engaging biography of Leo Sternbach, the brilliant chemist who invented Valium and whose achievements heralded the beginning of a new era in research and therapeutics. This thought-provoking biographical history: Tells the fascinating life story of one of the 20th century's premier chemists Traces the developments that led to the invention of Valium Provides a cultural history of Valium and its impact on society

Nature's Chemicals

Nature's Chemicals PDF

Author: Richard Firn

Publisher: Oxford University Press on Demand

Published: 2010

Total Pages: 261

ISBN-13: 0199566836

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This is the first monograph to describe Natural Products (NPs) as a group in an evolutionary context. It synthesizes a widely dispersed literature and provides a general picture of natural products encompassing evolution, history, ecology, and environmental issues, along with some deeper theory relevant to biochemistry.

Drug Discovery and Development

Drug Discovery and Development PDF

Author: Ramarao Poduri

Publisher: Springer Nature

Published: 2021-02-15

Total Pages: 522

ISBN-13: 9811555346

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This book describes the processes that are involved in the development of new drugs. The authors discuss the history, role of natural products and concept of receptor interactions with regard to the initial stages of drug discovery. In a single, highly readable volume, it outlines the basics of pharmacological screening, drug target identification, and genetics involved in early drug discovery. The final chapters introduce readers to stem therapeutics, pharmacokinetics, pharmacovigilance, and toxicological testing. Given its scope, the book will enable research scholars, professionals and young scientists to understand the key fundamentals of drug discovery, including stereochemistry, pharmacokinetics, clinical trials, statistics and toxicology.