Landscape with Mutant

Landscape with Mutant PDF

Author: Frederick Pollack

Publisher:

Published: 2018

Total Pages: 0

ISBN-13: 9780995767577

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Poems about US life before and during the Trump presidency, with its alienation, violence, and political despair. In this dystopian landscape, the weak exist to be trodden and those who are trodden are weak.' It is a book about casual racism, sharp-suited Fascism and the complicity of liberals in the assault on equality and justice. Between the nar

Molecular Evolution on Rugged Landscapes

Molecular Evolution on Rugged Landscapes PDF

Author: Alan S. Perelson

Publisher: CRC Press

Published: 2018-03-08

Total Pages: 328

ISBN-13: 042996742X

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This book lays out a number of the general issues concerning the structure of rugged fitness landscapes and examines both the history and the current status of experimental work on somatic mutation and the maturation of the immune response.

The Origins of Order

The Origins of Order PDF

Author: Stuart A. Kauffman

Publisher: Oxford University Press

Published: 1993-06-10

Total Pages: 734

ISBN-13: 9780199826674

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Stuart Kauffman here presents a brilliant new paradigm for evolutionary biology, one that extends the basic concepts of Darwinian evolution to accommodate recent findings and perspectives from the fields of biology, physics, chemistry and mathematics. The book drives to the heart of the exciting debate on the origins of life and maintenance of order in complex biological systems. It focuses on the concept of self-organization: the spontaneous emergence of order that is widely observed throughout nature Kauffman argues that self-organization plays an important role in the Darwinian process of natural selection. Yet until now no systematic effort has been made to incorporate the concept of self-organization into evolutionary theory. The construction requirements which permit complex systems to adapt are poorly understood, as is the extent to which selection itself can yield systems able to adapt more successfully. This book explores these themes. It shows how complex systems, contrary to expectations, can spontaneously exhibit stunning degrees of order, and how this order, in turn, is essential for understanding the emergence and development of life on Earth. Topics include the new biotechnology of applied molecular evolution, with its important implications for developing new drugs and vaccines; the balance between order and chaos observed in many naturally occurring systems; new insights concerning the predictive power of statistical mechanics in biology; and other major issues. Indeed, the approaches investigated here may prove to be the new center around which biological science itself will evolve. The work is written for all those interested in the cutting edge of research in the life sciences.

Recent Advances in the Theory and Application of Fitness Landscapes

Recent Advances in the Theory and Application of Fitness Landscapes PDF

Author: Hendrik Richter

Publisher: Springer Science & Business Media

Published: 2013-11-19

Total Pages: 577

ISBN-13: 3642418880

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This book is concerned with recent advances in fitness landscapes. The concept of fitness landscapes originates from theoretical biology and refers to a framework for analysing and visualizing the relationships between genotypes, phenotypes and fitness. These relationships lay at the centre of attempts to mathematically describe evolutionary processes and evolutionary dynamics. The book addresses recent advances in the understanding of fitness landscapes in evolutionary biology and evolutionary computation. In the volume, experts in the field of fitness landscapes present these findings in an integrated way to make it accessible to a number of audiences: senior undergraduate and graduate students in computer science, theoretical biology, physics, applied mathematics and engineering, but also researcher looking for a reference or/and entry point into using fitness landscapes for analysing algorithms. Also practitioners wanting to employ fitness landscape techniques for evaluating bio- and nature-inspired computing algorithms can find valuable material in the book. For teaching proposes, the book could also be used as a reference handbook.

Genetic and Evolutionary Computation — GECCO 2003

Genetic and Evolutionary Computation — GECCO 2003 PDF

Author: Erick Cantú-Paz

Publisher: Springer Science & Business Media

Published: 2003-06-30

Total Pages: 1317

ISBN-13: 3540406034

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The set LNCS 2723 and LNCS 2724 constitutes the refereed proceedings of the Genetic and Evolutionary Computation Conference, GECCO 2003, held in Chicago, IL, USA in July 2003. The 193 revised full papers and 93 poster papers presented were carefully reviewed and selected from a total of 417 submissions. The papers are organized in topical sections on a-life adaptive behavior, agents, and ant colony optimization; artificial immune systems; coevolution; DNA, molecular, and quantum computing; evolvable hardware; evolutionary robotics; evolution strategies and evolutionary programming; evolutionary sheduling routing; genetic algorithms; genetic programming; learning classifier systems; real-world applications; and search based software engineering.

Theoretical Models in Biology

Theoretical Models in Biology PDF

Author: Glenn Rowe

Publisher: Oxford University Press

Published: 1994

Total Pages: 444

ISBN-13: 9780198596875

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This book surveys the state of the art in theoretical and computer modeling for biological sciences. Using both mathematical and stochastic computer models of biological systems, the author focuses in particular on three central topics: the origin of life, the immune system, and memory in the brain. Throughout the book, the author emphasizes how the power of modern computers is allowing researchers in theoretical biology to break free of the constraints on modeling that were imposed by the traditional differential equation approach. Unique in its emphasis on modeling and computer simulation, Theoretical Models in Biology: The Origin of Life, the Immune System, and the Brain will be welcomed by students and researchers of mathematical biology.

Theoretical Immunology, Part One

Theoretical Immunology, Part One PDF

Author: Alan S. Perelson

Publisher: CRC Press

Published: 2018-03-05

Total Pages: 427

ISBN-13: 0429961251

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Assuming that the complex phenomena underlying the operation of the immune system may be better understood through the collaborative efforts of theorists and experimentalists viewing the same phenomena in different ways, the Sante Fe Institute and the Theoretical Division of Los Alamos National Laboratory cosponsored a workshop entitled "Theoretical Immunology". The workshop focused on themes spanning the field of immunology, with emphasis on areas where the theorists have made the most progress. This book covers the discussions a that workshop on the topics of immune surveillance, mathematical models of HIV infection, complexities of antigen-antibody systems, immune suppression and tolerance, and idiotypie networks. In each of these areas there is reason to believe that advances can be made either through interactions among experimentalists and theorists or through the critical look experimentalists and theorists will bring to bear upon one another's work.

Evolutionary Approaches to Protein Design

Evolutionary Approaches to Protein Design PDF

Author:

Publisher: Elsevier

Published: 2000-10-19

Total Pages: 451

ISBN-13: 0080493378

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This is the first high-quality, comprehensive overview of the field of evolutionary protein design. Topics include new protein design strategies, the structures of laboratory-evolved proteins, the evolution of non-natural enzyme functions, and the theory of laboratory evolution.

Algebraic and Discrete Mathematical Methods for Modern Biology

Algebraic and Discrete Mathematical Methods for Modern Biology PDF

Author: Raina Robeva

Publisher: Academic Press

Published: 2015-05-09

Total Pages: 383

ISBN-13: 0128012714

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Written by experts in both mathematics and biology, Algebraic and Discrete Mathematical Methods for Modern Biology offers a bridge between math and biology, providing a framework for simulating, analyzing, predicting, and modulating the behavior of complex biological systems. Each chapter begins with a question from modern biology, followed by the description of certain mathematical methods and theory appropriate in the search of answers. Every topic provides a fast-track pathway through the problem by presenting the biological foundation, covering the relevant mathematical theory, and highlighting connections between them. Many of the projects and exercises embedded in each chapter utilize specialized software, providing students with much-needed familiarity and experience with computing applications, critical components of the "modern biology" skill set. This book is appropriate for mathematics courses such as finite mathematics, discrete structures, linear algebra, abstract/modern algebra, graph theory, probability, bioinformatics, statistics, biostatistics, and modeling, as well as for biology courses such as genetics, cell and molecular biology, biochemistry, ecology, and evolution. Examines significant questions in modern biology and their mathematical treatments Presents important mathematical concepts and tools in the context of essential biology Features material of interest to students in both mathematics and biology Presents chapters in modular format so coverage need not follow the Table of Contents Introduces projects appropriate for undergraduate research Utilizes freely accessible software for visualization, simulation, and analysis in modern biology Requires no calculus as a prerequisite Provides a complete Solutions Manual Features a companion website with supplementary resources

Thinking About Biology

Thinking About Biology PDF

Author: Wilfred Stein

Publisher: CRC Press

Published: 2018-03-08

Total Pages: 356

ISBN-13: 0429961200

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This book discusses the emergence of life, the development of the individual, and the study of the interaction between individuals and species. It gives the student of theoretical biology some idea of the flavor of current research in the field.