Laboratory biosecurity guidance

Laboratory biosecurity guidance PDF

Author: World Health Organization

Publisher: World Health Organization

Published: 2024-06-21

Total Pages: 110

ISBN-13: 924009511X

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The Laboratory biosecurity guidance is a revision of the first edition of the WHO Biorisk management - Laboratory biosecurity guidance, 2006. As introduced in the 4th edition of the Laboratory biosafety manual (LBM4), the novel risk- and evidence-based approach is applied for biosecurity in this guidance. The guidance is intended to help researchers, biosafety/biosecurity officers and other laboratory personnel properly assess and manage risks inherent to high-consequence research. Furthermore, it contains a template for biosecurity risk assessment in the laboratory to prevent theft, misuse and unauthorized access to biological material, and also includes a two-tier approach for national oversight of biological risk management as well as a hybrid approach with risk- and list-based elements to regulate high-consequence material.

Laboratory Biosecurity Handbook

Laboratory Biosecurity Handbook PDF

Author: Reynolds M. Salerno

Publisher: CRC Press

Published: 2007-06-21

Total Pages: 210

ISBN-13: 1420006207

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By achieving a delicate balance between systems and practices, proper laboratory biosecurity reduces the risk of legitimate bioscience facilities becoming sources of pathogens and toxins for malicious use. Effective design and implementation of laboratory biosecurity depends on cooperation among individuals from diverse communities, including scien

Laboratory Biorisk Management

Laboratory Biorisk Management PDF

Author: Reynolds M. Salerno

Publisher: CRC Press

Published: 2015-12-01

Total Pages: 264

ISBN-13: 1498749747

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Over the past two decades bioscience facilities worldwide have experienced multiple safety and security incidents, including many notable incidents at so-called "sophisticated facilities" in North America and Western Europe. This demonstrates that a system based solely on biosafety levels and security regulations may not be sufficient. Setting the stage for a substantively different approach for managing the risks of working with biological agents in laboratories, Laboratory Biorisk Management: Biosafety and Biosecurity introduces the concept of biorisk management—a new paradigm that encompasses both laboratory biosafety and biosecurity. The book also provides laboratory managers and directors with the information and technical tools needed for its implementation. The basis for this new paradigm is a three-pronged, multi-disciplinary model of assessment, mitigation, and performance (the AMP model). The application of the methodologies, criteria, and guidance outlined in the book helps to reduce the risk of laboratories becoming the sources of infectious disease outbreaks. This is a valuable resource for those seeking to embrace and implement biorisk management systems in their facilities and operations, including the biological research, clinical diagnostic, and production/manufacturing communities.

Ethical and Philosophical Consideration of the Dual-Use Dilemma in the Biological Sciences

Ethical and Philosophical Consideration of the Dual-Use Dilemma in the Biological Sciences PDF

Author: Seumas Miller

Publisher: Springer Science & Business Media

Published: 2008-07-30

Total Pages: 79

ISBN-13: 1402083122

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What Is the Dual-Use Dilemma? The so-called “dual-use dilemma” arises in the context of research in the biological and other sciences as a consequence of the fact that one and the same piece of sci- tific research sometimes has the potential to be used for harm as well as for good. A dual-use dilemma is an ethical dilemma, and an ethical dilemma for the researcher (and for those who have the power or authority to assist or impede the researcher’s work, e. g. , governments). It is an ethical dilemma since it is about promoting good in the context of the potential for also causing harm, e. g. , the p- motion of health in the context of providing the wherewithal for the killing of in- cents. It is an ethical dilemma for the researcher not because he or she is aiming at anything other than a good outcome; typically, the researcher intends no harm, but only good. Rather, the dilemma arises for the researcher because of the potential actions of others. Malevolent non-researchers might steal dangerous biological agents produced by the researcher; alternatively, other researchers—or at least their governments or leadership—might use the results of the original researcher’s work for malevolent purposes. The malevolent purposes in question include bioterrorism, biowarfare and blackmail for financial gain.

Laboratory Biosafety Manual

Laboratory Biosafety Manual PDF

Author: World Health Organization

Publisher: World Health Organization

Published: 2004-12-28

Total Pages: 196

ISBN-13: 9789241546508

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This is the third edition of this manual which contains updated practical guidance on biosafety techniques in laboratories at all levels. It is organised into nine sections and issues covered include: microbiological risk assessment; lab design and facilities; biosecurity concepts; safety equipment; contingency planning; disinfection and sterilisation; the transport of infectious substances; biosafety and the safe use of recombinant DNA technology; chemical, fire and electrical safety aspects; safety organisation and training programmes; and the safety checklist.

Potential Risks and Benefits of Gain-of-Function Research

Potential Risks and Benefits of Gain-of-Function Research PDF

Author: National Research Council

Publisher: National Academies Press

Published: 2015-04-13

Total Pages: 140

ISBN-13: 0309367867

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On October 17, 2014, spurred by incidents at U.S. government laboratories that raised serious biosafety concerns, the United States government launched a one-year deliberative process to address the continuing controversy surrounding so-called "gain-of-function" (GOF) research on respiratory pathogens with pandemic potential. The gain of function controversy began in late 2011 with the question of whether to publish the results of two experiments involving H5N1 avian influenza and continued to focus on certain research with highly pathogenic avian influenza over the next three years. The heart of the U.S. process is an evaluation of the potential risks and benefits of certain types of GOF experiments with influenza, SARS, and MERS viruses that would inform the development and adoption of a new U.S. Government policy governing the funding and conduct of GOF research. Potential Risks and Benefits of Gain-of-Function Research is the summary of a two-day public symposia on GOF research. Convened in December 2014 by the Institute of Medicine and the National Research Council, the main focus of this event was to discuss principles important for, and key considerations in, the design of risk and benefit assessments of GOF research. Participants examined the underlying scientific and technical questions that are the source of current discussion and debate over GOF research involving pathogens with pandemic potential. This report is a record of the presentations and discussion of the meeting.

Biological Laboratory Applied Biosecurity and Biorisk Managemnet Guide

Biological Laboratory Applied Biosecurity and Biorisk Managemnet Guide PDF

Author:

Publisher:

Published: 2015-08-15

Total Pages: 219

ISBN-13: 9780692457412

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The BIOLOGICAL LABORATORY APPLIED BIOSECURITY AND BIORISK MANAGEMENT GUIDE is a definitive and comprehensive tutorial text that, for the first time, provides a specific reference for training Biorisk and Biosecurity students or other biological community professionals. The topics included range from a clear, concise definition of Biorisk from a laboratory biosecurity perspective, biosafety/biosecurity comparisons and contracts, U.S. and WHO regulations and guidance, a unique laboratory biorisk assessment model, bio-terrorism reality, public health issues, research topics, laboratory physical security, emergency planning, export control and conducting business in foreign countries among other germane topics of interest.The cascading events in the aftermath of 9/11/2001, and the biological attacks that immediately followed have given rise to a significant proliferation of biological laboratories working with dangerous pathogens both domestically and internationally. The quest to develop effective medical countermeasures, conduct research, and provide safe and secure laboratory environments has also resulted in significant increases in funding. The expansion of this capacity has also resulted in the creation of a myriad of legislation, regulations and guidelines that are designed to protect laboratory staff, the public and ensure that these pathogens are properly secured. Ultimately, the convergence of these issues has contributed to the emergence of a new security subject matter expert category, Biological Security Professional. Currently there exists very few security management professionals specifically trained in biological security and biorisk management, to meet the needs and demand world-wide. The intent of this manual is to provide the fundamental information for new security practitioners just entering the field and the more experienced professional that is seeking to transition into the field of biological laboratory security and biorisk management. There is compelling evidence suggesting that the need for the biosecurity specialty subject matter expert will continue to grow exponentially in the near and long term, throughout the world. The ultimate goal is to assist in the proliferation of One Health world-wide and to create a professional discipline to prevent and mitigate the full spectrum of biological risks, threats and vulnerabilities