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Interleukin 2

Author: Kendall A Smith

Publisher: Elsevier

Published: 2012-12-02

Total Pages: 334

ISBN-13: 0323139949

Interleukin 2 focuses on interleukin 2 (IL-2) and its impact on immunology. Topics covered include IL-2's mechanism of action, the structure of the IL-2 receptor, the characteristics of natural and recombinant human IL-2, regulation of IL-2 production by the T cell antigen receptor, how IL-2 binding induces the transcription of a novel set of genes, and the pathological roles of IL-2 receptor inducers in adult T cell leukemia. This book is comprised of 12 chapters and begins with a historical overview of IL-2, from the discovery of soluble mitogenic factors in culture media of stimulated lymphocytes to the discovery of IL-2 as the molecule responsible for stimulating T cell proliferation. The physicochemical and biological properties of purified recombinant IL-2 are then described, paying particular attention to natural IL-2 derived from human peripheral blood leukocytes. The chapters that follow discuss the different techniques used to gain insight into the functionally important regions of IL-2, the role of the T cell antigen receptor in regulating the production of IL-2, and the structure of the human high-affinity IL-2 receptor. The book also describes transmembrane signaling by IL-2, IL-2-inducible gene expression in T lymphocytes, abnormal IL-2 receptor expression in adult T cell leukemia, the use of IL-2 receptors in immunosuppressive therapy, and the use of IL-2 as a pharmacologic reagent. This book will be of interest to students and researchers in immunology and biochemistry.

The role of interleukin-2 in the treatment of cancer patients

Author: J. Wagstaff

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 195

ISBN-13: 9401117535

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Recombinant human interleukin-2 became available for clinical use in the mid 1980s. Recent years have seen an enormous amount of clinical research with this cytokine and interleukin-2 has now been registered for use in a number of European countries for the treatment of metastatic renal cell carcinoma. This book is designed to provide the clinical oncologist wishing to use interleukin-2 with a basic background concerning the biology of the agent, a discussion concerning practical aspects, of its clinical use including management of toxicity and an overview of the clinical results together with a description of how this internesting cytokine might be developed in the future.

Encyclopedia of Inflammatory Diseases

Author:

Publisher: Birkhäuser

Published: 2016-09-15

Total Pages: 0

ISBN-13: 9783764385309

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Inflammation has become one of the most exciting and rewarding areas of medical research. Recent years have seen a revolution in our understanding of how blood and tissue cells interact and of the intracellular mechanisms controlling their activation. This has revealed the underlying inflammatory pathology of many diseases and provided multiple new targets for anti-inflammatory and immunomodulatory therapy. The Encyclopedia of Inflammatory Diseases will cover the following areas: Inflammatory Processes and Cells Inflammatory Diseases Mediators of Inflammation Pharmacology of Inflammation Since inflammatory diseases and their therapy cover a broad range of scientific and medical fields, the encyclopedia will be co-edited by four international experts, a clinician and three researchers from the disciplines of immunology, biochemistry, and pharmacology, in this way providing students, basic and clinical scientists and practitioners in academia, hospitals and industry with valuable interlinked information. This living project will serve as a reliable and comprehensive data pool for everybody working in inflammation research. Owing to its dynamic nature, it will grow with time and future editions, becoming an indispensible source of information for academia, clinical practitioners and industry.

Interleukin-2 and Killer Cells in Cancer

Author: Eva Lotzova

Publisher: CRC Press

Published: 2018-02-01

Total Pages: 381

ISBN-13: 1351082248

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This is the first-and only-publication available which provides the most recent information in this particular field of biomedicine. Interleukin-2 (IL-2) and IL-2 activated killer cells have been shown to have a potential in the treatment of a variety of human malignant diseases. This work comprehensively summarizes basic aspects of IL-2 as well as its clinical application, therefore making all these aspects easily accessible to the readers. Because of the clinical significance of this molecule in the treatment of cancer, the basic and clinical investigations in the IL-2 field are rapidly expanding, together with the interest of the scientific and medical community. This book is an excellent educational and teaching tool for scientists, clinicians, and students. Those who already have expertise in research in the IL-2 area will find this reference indispensible.

Managing Interleukin-2 Therapy

Author: National Institutes of Health (U.S.). Clinical Center. Cancer Nursing Service. 2 East Nursing Staff

Publisher:

Published: 1989

Total Pages: 20

ISBN-13:

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Between Bench and Bedside

Author: Ilana Löwy

Publisher: Harvard University Press

Published: 1996

Total Pages: 396

ISBN-13: 9780674068094

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Between Bench and Bedside is a compelling account of the clinical trials of interleukin-2 at a major French cancer hospital. Löwy's book offers a remarkable insider's view of the culture of clinical experimentation in oncology.

Cooperation of Liver Cells in Health and Disease

Author: Z. Kmiec

Publisher: Springer Science & Business Media

Published: 2013-06-29

Total Pages: 154

ISBN-13: 3642565530

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It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.

The Biology and Clinical Applications of Interleukin-2

Author: Robert C. Rees

Publisher: IRL Press

Published: 1990

Total Pages: 208

ISBN-13:

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The molecular structure of interleukin-2 (IL-2) and that of its receptor subunits provide a basis for understanding lymphocyte activation by IL-2 and the generation of effector cells capable of mediating cytotoxicity towards tumors. This book provides an up-to-date account of IL-2, its effect on lymphocyte function, and clinical applications. Internationally know experts review the molecular aspects of cell signalling, giving insight on the in vivo pathways of activation likely to be important in determining clinical responses. They also examine the use of cytokines, particularly IL-2, in the treatment of cancer, and describe the results of recent clinical trials using IL-2, as well as of adoptive cell therapy. Providing a clear account of recent progress, the book also reviews the problems involved in attempting to improve the therapeutic benefit of IL-2, along with the importance of mechanisms which subverse IL-2 responses. This is the most up-to-date account of molecular research and clinical trials in this area, and will be of great benefit to students and researchers in immunology, pharmacology, biochemistry, and oncology who are interested in this vitally important topic.

Dynamics of the Il-2 Cytokine Network and T-cell Proliferation

Author: Dorothea Busse

Publisher: Logos Verlag Berlin GmbH

Published: 2010

Total Pages: 114

ISBN-13: 3832526935

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This book adds to a intensively investigated question of immunological research. How do regulatory T cells mediate their function to ensure tolerance against self-antigen? The author analyzes the interaction via the cytokine interleukin 2 between T helper cells, which mediate immune responses, and regulatory T cells. Since both cell types depend on interleukin 2 to mediate their functions, competition for interleukin 2 is likely. A mathematical model is developed to describe the interaction. This model focuses on the interleukin 2 receptor dynamics on helper and regulatory T cells and the extracellular interleukin 2 diffusion. The interleukin 2 receptor dynamics is governed mainly by an autocrine positive feedback loop on both cell types. However, its differential regulation results in a switch-like up-regulation of the receptors on T helper cells and a gradual adaptation of the receptor levels to extracellular interleukin 2 supply on regulatory T cells. This difference enables regulatory T cells to efficiently compete for interleukin 2 and deprive T helper cells of their growth factor. Cell culture experiments verify these findings. It can be shown that the antigen stimulus and the intercellular distance are relevant control parameters for competition. Other mechanisms are described for suppression of T helper cell action by regulatory T cells; competition for interleukin 2 may act in concert with them.

The Interleukins

Author: Steven Gillis

Publisher: Springer Science & Business Media

Published: 2013-03-14

Total Pages: 305

ISBN-13: 1468448382

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Investigations of the activation, proliferation, and, in some cases, differentia tion of mononuclear cells involved in the immune response are proceeding rapidly. These studies have resulted in the discovery of several factors that promote these cellular events, some of which have been characterized biochemically to various extents. Because of the considerable interest in understanding these cellular changes at the molecular level, we chose to produce the first thematic volume for Contemporary Topics in Molecular Immunology; the theme deals with certain regulatory factors that promote proliferation and differentiation. We have com piled contributions from numerous scientists well known for their work with several regulatory factors. In the following paragraphs, the reader will find an overview of the contents of this volume. Greene and Robb review data they have generated over the past 2-3 years with respect to characterization of hormone-specific Interleukin-2 (IL-2) recep tors on the surface of activated T cells. Their chapter traces the development of a quantitative assay for assessment of IL-2 receptors based on the preparation and use of radiolabeled IL-2 prepared biosynthetically with the aid of IL-2-pro ducer leukemic cells. The authors then describe an alternate approach, the prep aration of a monoclonal antibody previously determined to be directed against a T -cell-activation antigen. This so-called anti-Tac antibody was later found to recognize a determinant on or near the IL-2 receptor.