Inflammatory Cardiomyopathy (DCMi) - Pathogenesis and Therapy

Inflammatory Cardiomyopathy (DCMi) - Pathogenesis and Therapy PDF

Author: Heinz-Peter Schultheiss

Publisher: Springer Science & Business Media

Published: 2011-01-30

Total Pages: 295

ISBN-13: 3764383526

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Cardiomyopathy is one of the most frequent causes of heart failure. It is often associated with inadequate heart pumping or other heart function abnormalities. There are many different causes of the disease, therefore many different kinds of cardiomyopathies exist. This volume, written by a leading expert, focuses on inflammatory CM, belonging to the Dilated Cardiomyopathies (DCMi). It covers epidemiology/prognosis, pathology, immunology, diagnosis and treatment strategies.

Myocarditis

Myocarditis PDF

Author: Alida L. P. Caforio

Publisher: Springer Nature

Published: 2020-03-06

Total Pages: 353

ISBN-13: 3030352765

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This book is an up-to-date, comprehensive, clinically oriented guide to the diagnosis and treatment of patients with myocarditis. The opening chapters address the classification, histopathology and molecular diagnosis, as well as the polymorphic clinical presentations, ranging from myocardial infarction with normal coronary arteries; arrhythmias of variable type and clinical severity and fulminant, acute, sub-acute or chronic heart failure; to life-threatening unexplained cardiogenic shock and sudden cardiac death. Including chapters from leading International experts in the field, it covers all key issues from bench to bedside. Topics presented include epidemiology, etiology, pathogenesis, clinical and diagnostic work-up, the role of endomyocardial biopsy and of non-invasive cardiac imaging, risk stratification, and cardiological and etiology-specific management and follow-up. For each topic, a comprehensive review of the current literature is provided and practical suggestions are offered for short- and long-term management. Lastly, future perspectives and gaps in the current knowledge are also addressed. The book also covers a key discovery of last the 2 decades, namely the autoimmune origin of myocarditis in a sizable proportion of patients, discussing in detail the role of immunosuppression and immunomodulation, as well as the need for a multidisciplinary approach to the disease. Mainly intended for cardiologists, general physicians, clinical immunologists and rheumatologists, it is also a valuable tool for residents in Cardiology, Internal Medicine, Clinical Immunology and Rheumatology.

Stage B, a Pre-cursor of Heart Failure, An Issue of Heart Failure Clinics - E-Book

Stage B, a Pre-cursor of Heart Failure, An Issue of Heart Failure Clinics - E-Book PDF

Author: Jay N. Cohn

Publisher: Elsevier Health Sciences

Published: 2012-01-28

Total Pages: 187

ISBN-13: 1455742848

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In the joint American College of Cardiology /American Heart Association classification system, Stage B heart failure refers to patients with structural heart disease but no symptoms of heart failure. Preventing progression of heart failure in Stage B patients is a central concern to heart failure specialists, so two issues have been devoted to this topic. Part I focuses on an understanding of structural heart disease and the factors that cause progression from risk of heart failure to development of structural changes.

Trends in Inflammation Research

Trends in Inflammation Research PDF

Author: James A. Pitzer

Publisher: Nova Publishers

Published: 2006

Total Pages: 198

ISBN-13: 9781600210082

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The process of inflammation, which causes the swelling and redness around a wound, is a vital part of the body's system for fighting off infections. When the body is hurt, the immune system produces chemical signals telling cells to multiply without dying, allowing skin to close over a gash, for example. Other chemicals spur the growth of new blood vessels to feed the recovering tissue. Scientists have linked inflammation to cancer and recently to heart disease in several ways. Doctors suspect that long-term inflammation or infection is involved in up to 20 per cent of cancers, including those of the oesophagus, colon, skin, stomach, liver, bladder, breast and some kinds of lymphoma. C-reactive protein (CRP) is one of the acute phase proteins that increase during systemic inflammation. It's been suggested that testing CRP levels in the blood may be a new way to assess cardiovascular disease risk. A high sensitivity assay for CRP test (hs-CRP) is now widely available. This book presents recent leading-edge research from around the world.

Cellular and Molecular Pathobiology of Cardiovascular Disease

Cellular and Molecular Pathobiology of Cardiovascular Disease PDF

Author: Monte Willis

Publisher: Academic Press

Published: 2013-12-23

Total Pages: 339

ISBN-13: 0124055257

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Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical departments. The text is complemented and supported by a rich variety of photomicrographs, diagrams of molecular relationships, and tables. It is uniquely useful to a wide audience of graduate students and post-doctoral fellows in areas from pathology to physiology, genetics, pharmacology, and more, as well as medical residents in pathology, laboratory medicine, internal medicine, cardiovascular surgery, and cardiology. Explains how to identify cardiovascular pathologies and compare with normal physiology to aid research Gives concise explanations of key issues and background reading suggestions Covers molecular bases of diseases for better understanding of molecular events that precede or accompany the development of pathology

The Hygiene Hypothesis and Darwinian Medicine

The Hygiene Hypothesis and Darwinian Medicine PDF

Author: Graham A.W. Rook

Publisher: Springer Science & Business Media

Published: 2009-12-24

Total Pages: 312

ISBN-13: 3764389036

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Man has moved rapidly from the hunter-gatherer environment to the living conditions of industrialised countries. The hygiene hypothesis suggests that the resulting reduced exposure to micro-organisms has led to disordered regulation of the immune system, and hence to increases in certain chronic inflammatory disorders, like allergic disorders, autoimmunity, inflammatory bowel disease, atherosclerosis, depression, some cancers and perhaps Alzheimer and Parkinson. This book discusses the evidence for and against in the context of Darwinian medicine, which uses knowledge of evolution to cast light on human diseases. The approach is interdisciplinary, looking at man’s microbiological history, at the biology of the effects of microorganisms on the immune system, and at the implications for chronic inflammatory disorders in multiple organ systems. Finally, the authors describe progress in the exploitation of microorganisms or their components as novel prophylactics and treatments.

Forensic Histopathology

Forensic Histopathology PDF

Author: Reinhard B. Dettmeyer

Publisher: Springer

Published: 2018-05-18

Total Pages: 570

ISBN-13: 3319779974

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This second edition, which combines the features of an atlas and a textbook, presents findings in forensic histology, immunohistochemistry, and cytology based on microscopic investigations using different stainings and different antibodies. Questions of quality when working in the field of forensic histology are included as well as scientific perspectives for further research. The principal aim is to provide practitioners with detailed information and guidance on how microscopy can help to clarify the cause of sudden and unexpected death. Therefore additional and particularly rare histopathological findings are presented. Many of the topics will be of interest not only to forensic pathologists but also to general pathologists, whether practitioners or researchers. Examples include the pathology of drug abuse, wound age determination, adverse drug reactions, histopathology of the sudden infant death syndrome, and age determination of myocardial infarction. Both typical and unusual findings are demonstrated with the aid of numerous high-quality color illustrations, and other key literature in forensic histology and immunohistochemistry is highlighted for each topic.

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