Infectious Process and Sepsis

Infectious Process and Sepsis PDF

Author: Vincenzo Neri

Publisher: BoD – Books on Demand

Published: 2020-07-15

Total Pages: 104

ISBN-13: 1838803939

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Sepsis is a very complex clinical condition that can be considered the central point of the infectious process: the arrival point in the evolution of a localized septic outbreak that has caused a systemic inflammatory reaction. In the clinical setting two important questions regarding the transition from local inflammation, with beneficial effect, to systemic inflammatory disease, with deleterious results, remain unanswered. First, why does the transition from local to systemic disease only occur in some subjects? Second, how long does this transition take? This book attempts to answer these questions. Chapters cover such topics as surgical infections, microbiota therapy in sepsis, cytokines for host immune response, and the role of serum amyloid A in the acute phase of sepsis.

Infections and Sepsis Development

Infections and Sepsis Development PDF

Author: Vincenzo Neri

Publisher: BoD – Books on Demand

Published: 2021-10-27

Total Pages: 396

ISBN-13: 1839694572

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Infection is a common clinical condition that may cause local inflammation but, in some cases, can lead to systemic inflammation, with sepsis and organ dysfunction. Septic shock is a condition of inadequate tissue perfusion and cellular use of oxygen due to the cytotoxic action of bacterial toxins. There is no relationship between the pathological characteristics and the severity of the primary septic outbreak and the development of septic shock, and the time that elapses until the start of the shock is not predictable. Thus, knowledge of the pathophysiology of septic shock is fundamental for treatment. This book presents a comprehensive overview of infectious agents and their therapeutic control, pathological conditions with infective etiology such as diabetic foot osteomyelitis and infections in neurosurgery, and the pathophysiology, diagnosis, and management of sepsis.

Handbook of Sepsis

Handbook of Sepsis PDF

Author: W. Joost Wiersinga

Publisher: Springer

Published: 2018-04-13

Total Pages: 267

ISBN-13: 3319735063

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This practically oriented book provides an up-to-date overview of all significant aspects of the pathogenesis of sepsis and its management, including within the intensive care unit. Readers will find information on the involvement of the coagulation and endocrine systems during sepsis and on the use of biomarkers to diagnose sepsis and allow early intervention. International clinical practice guidelines for the management of sepsis are presented, and individual chapters focus on aspects such as fluid resuscitation, vasopressor therapy, response to multiorgan failure, antimicrobial therapy, and adjunctive immunotherapy. The closing section looks forward to the coming decade, discussing novel trial designs, sepsis in low- and middle-income countries, and emerging management approaches. The book is internatio nal in scope, with contributions from leading experts worldwide. It will be of value to residents and professionals/practitioners in the fields of infectious diseases and internal medicine, as well as to GPs and medical students.

Janeway's Immunobiology

Janeway's Immunobiology PDF

Author: Kenneth Murphy

Publisher: Garland Science

Published: 2010-06-22

Total Pages:

ISBN-13: 9780815344575

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The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Health Professionals for a New Century

Health Professionals for a New Century PDF

Author:

Publisher: Harvard School of Public Health, Frangois-Xavier Bagnoud Cen

Published: 2011

Total Pages: 95

ISBN-13: 9780674061484

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One hundred years ago a series of seminal documents, starting with the Flexner Report of 1910, sparked an enormous burst of energy to harness the power of science to transform higher education in health. Professional education, however, has not been able to keep pace with the challenges of the 21st century. A new generation of reforms is needed to meet the demands of health systems in an interdependent world. The report of the Commission on the Education of Health Professionals for the 21st Century, a global independent initiative consisting of 20 leaders from diverse disciplinary backgrounds and institutional affiliations, articulates a fresh vision and recommends renewed actions. Building on a rich legacy of educational reforms during the past century, the Commission's findings and recommendations adopt a global and multi-professional perspective using a systems approach to analyze education and health, with a focus on institutional and instructional reforms.

Core Concepts in Clinical Infectious Diseases (CCCID)

Core Concepts in Clinical Infectious Diseases (CCCID) PDF

Author: Carlos Franco-Paredes

Publisher: Academic Press

Published: 2016-03-16

Total Pages: 244

ISBN-13: 0128044802

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Core Concepts in Clinical Infectious Diseases (CCID) provides medical students and researchers, infectious disease fellows, and practicing clinicians with key clinical concepts in the differential diagnosis and workup of infectious diseases. With the use of tables, charts, and problem-oriented medical diagnosis, it will provide a way of organizing and thinking about commonly seen clinical presentations of infectious diseases. Instead of discussing each disease process or any particular infectious process, this book will assist clinicians in seeing the forest and not focusing on the leaf. Graphs and tables have been constructed over 14 years of taking notes, teaching clinical infectious diseases, and discussing real clinical cases. This book is not about acquiring the structure of infectious diseases that is presented in classic textbooks of infectious disease; instead, it is about refining the process of putting the pieces together in clinical thinking to achieve an accurate clinical diagnosis and thus improved patient care. Assists the reader in connecting the dots (process of accumulating real-time knowledge) during the thinking process of clinical decision-making in the area of infectious diseases Uses tables and charts for easy understanding and application Contains a manual style that targets different audiences, such as medical students, hospital medicine specialists, outpatient internal medicine practitioners, infectious disease fellows in training, and practicing clinicians Provides an up-to-date discussion of core concepts in clinical infectious diseases

Clinical Management of Shock

Clinical Management of Shock PDF

Author: Stanislaw P. Stawicki

Publisher: BoD – Books on Demand

Published: 2020-06-24

Total Pages: 210

ISBN-13: 1838811702

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Shock is a physiological state of war! From a healthcare provider perspective, the word “shock” is associated with a mixed array of feelings, including dread, well-founded fear, and deep respect. The physiological state of shock is well recognized for the associated destructive consequences, and its successful management requires prompt identification, immediate action, and sustained effort by all members of the healthcare team. This mindset of advanced preparation and constant readiness constitutes the foundation of the modern approach toward shock – early detection and prompt treatment for optimal outcomes. Despite the heterogeneity of “shock” as a clinico-pathological entity, there are some common threads that permeate all forms and manifestations of shock, with apparent increase in observed commonalities in the more advanced (and often irreversible) stages of the systemic syndrome. When faced with shock, the body and its systems do their best to compensate for the maldistribution of oxygen and nutrients. This is known as the so-called compensated shock. Beyond that, the body loses its ability to adjust any further, thus descending into “uncompensated shock,” with a refractory state characterized by vasoplegia and irreversible cardiovascular failure. As the reader journeys through the chapters of the book, he or she will read about various biomarkers and endpoints of resuscitation, explore different types of shock (e.g., septic, hemorrhagic, anaphylactic) and learn about some of the less often discussed topics such as neurogenic and spinal shock, as well as the amniotic fluid embolism. Our goals were to keep things clinically relevant and practically oriented, thus enabling the reader to apply the newly acquired knowledge in their everyday clinical routines. As the reader progresses through the book, we hope to help stimulate further discourse and innovative thinking about the topic. In this context, it is critical that basic, translational, and clinical research on shock continues to advance. Only through ongoing scientific progress can we help improve outcomes for patients with both rare and common forms of shock.

Biomarker

Biomarker PDF

Author: Ghousia Begum

Publisher: BoD – Books on Demand

Published: 2018-09-05

Total Pages: 250

ISBN-13: 1789236665

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This book investigates the emerging use of biomarkers as a diagnostic tool for the identification of patients with an abnormal condition or as a tool for staging the extent of disease, as an indicator of disease prognosis. Chapters in Part I focus on biomarkers for cancer, including breast cancer and pancreatic cancer, as well as circulating microRNA profiling in cancer biomarker discovery. Chapters in Part II focus on biomarkers of other diagnoses/diseases, including sepsis, childhood renal diseases, pulmonary diseases, Alzheimer's, leishmaniasis, and heart failure. This book investigates the emerging use of biomarkers as a diagnostic tool for the identification of patients with an abnormal condition or as a tool for staging the extent of disease, as an indicator of diseases prognosis. The book is of considerable importance for a broad range of people including researchers, clinicians, and university students.

General Trauma Care and Related Aspects

General Trauma Care and Related Aspects PDF

Author: Hans-Jörg Oestern

Publisher: Springer Science & Business Media

Published: 2013-10-22

Total Pages: 294

ISBN-13: 3540881247

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There currently is a clear tendency to an increasing number of accidental injuries in elderly people, in sport injuries and car crashes also in countries which recently joined the European Union and candidates to join the European Union. Patients expect very good functional results even after serious injuries. But in contrast to this development, Trauma Surgery as an independent field, is not yet established in all European countries. Therefore, it seems mandatory to compile a book that covers the state-of-the-art in Trauma Surgery. The book also serves to harmonise the practice of Trauma Surgery within the European Union, and to prepare for the exam of the U.E.M.S.

Treating Infectious Diseases in a Microbial World

Treating Infectious Diseases in a Microbial World PDF

Author: National Research Council

Publisher: National Academies Press

Published: 2006-01-03

Total Pages: 102

ISBN-13: 0309180686

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Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.