Immunosenescence and Multiple Sclerosis: Prognostic and Therapeutic Implications
Author: Emanuele D’amico
Publisher: Frontiers Media SA
Published: 2022-10-13
Total Pages: 144
ISBN-13: 2832502326
DOWNLOAD EBOOK →Lanterna Rally
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Neuroimmunological Diseases
Author: Susumu Kusunoki
Publisher: Springer
Published: 2018-05-31
Total Pages: 0
ISBN-13: 9784431566656
DOWNLOAD EBOOK →This book offers a detailed review of the remarkable advances that have been made in research on the pathogenesis of a number of neuroimmunological diseases, as well as outlining novel treatments including the use of monoclonal antibodies. Written by renowned experts who have made major contributions in the field, such as identifying neuromyelitis optica as an immunopathological clinical condition, identifying the role of ganglioside and ganglioside-complex antibodies in Guillain-Barré syndrome, and developing a novel treatment for POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes) syndrome, the book summarizes recent advances in basic and clinical research. Neuroimmunological Diseases is a useful resource for not only researchers but also neurologists who are engaged in the management of neuroimmunological diseases.
Neuropsychiatric Disorders and Epigenetics
Author: Jacob Peedicayil
Publisher: Elsevier
Published: 2023-09-29
Total Pages: 418
ISBN-13: 0443185174
DOWNLOAD EBOOK →Neuropsychiatric Disorders and Epigenetics, Second Edition is a comprehensive reference on the epigenetic basis of common neuropsychiatric disorders. The volume is organized into chapters covering individual neuropsychiatric disorders, from addiction to anxiety and autism spectrum disorders, and is contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed, in the context of the full range of associated epigenetic mechanisms, including DNA modification, histone post-translational modification, chromatin organization, and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmental stimuli on epigenetic states is particularly relevant to disease. This new edition has been fully updated to reflect recent research advances enabled by genomic technologies, as well as therapeutic interventions for previously unmanageable disorders. Several new chapters have been added on disorders or approaches not considered in the earlier edition, including epigenetics and anxiety disorders, epigenetics and neuroimaging in neuropsychiatric disorders, genome-wide approaches to epigenetic research, and the epigenetics of spinal muscular atrophy. By helping to define epigenetics as a key player in neuropsychiatric disorders, this volume empowers new research, clinical translation, and pharmacological advances, and highlights promising directions for ongoing investigation. Analyzes the effects of environmental stimuli on epigenetic states that correlate with neuropsychiatric disease induction Reviews the epigenetic basis for common neuropsychiatric disorders, thereby guiding translational therapies for clinicians and mechanistic studies for scientists Features extensive use of diagrams, illustrations, tables, and graphical abstracts for each section to reinforce understanding Includes chapter contributions from leading global experts
Aging in multiple sclerosis: from childhood to old age, in women and men
Author: Alessandra Lugaresi
Publisher: Frontiers Media SA
Published: 2024-02-21
Total Pages: 152
ISBN-13: 2832543391
DOWNLOAD EBOOK →In recent years attention has been drawn on changes in multiple sclerosis (MS) prevalence according to sex and age. We are now aware that MS is not a disease with onset exclusively in the young adult, but that pediatric cases are not infrequent, as well as onset in older adults. The need to assess the role of aging, sexual hormones, diet, and infections, has boosted research in many areas, from immunology to imaging techniques to psychology. An increasing awareness of the impact of MS on personal and sexual relationships, with the need to assess patient related outcomes also in clinical trials, has driven research not only in psychology, but in many other areas. The need to integrate information from all these different research areas is deeply felt.
Immune Aspects of Biopharmaceuticals and Nanomedicines
Author: Raj Bawa
Publisher: CRC Press
Published: 2019-01-10
Total Pages: 602
ISBN-13: 1351399772
DOWNLOAD EBOOK →The enormous advances in the immunologic aspects of biotherapeutics and nanomedicines in the past two decades has necessitated an authoritative and comprehensive reference source that can be relied upon by immunologists, biomedical researchers, clinicians, pharmaceutical companies, regulators, venture capitalists, and policy makers alike. This text provides a thorough understanding of immunology, therapeutic potential, clinical applications, adverse reactions, and approaches to overcoming immunotoxicity of biotherapeutics and nanomedicines. It also tackles critical, yet often overlooked topics such as immune aspects of nano-bio interactions, current FDA regulatory guidances, complement activation-related pseudoallergy (CARPA), advances in nanovaccines, and immunogenicity testing of protein therapeutics.
Models, Molecules and Mechanisms in Biogerontology
Author: Pramod C. Rath
Publisher:
Published: 2019
Total Pages:
ISBN-13: 9789811335860
DOWNLOAD EBOOK →This book examines the basic cellular and molecular mechanisms associated with aging. It comprehensively describes the genetic, epigenetic, biochemical and metabolic regulation of aging, as well as some important age-related diseases. Divided into two major sections, it takes readers through the various aspects of aging in a story-like manner and suggests various interventions for healthy aging, such as dietary restriction, regular exercise, nutrition and maintaining a balanced and a non-stressful lifestyle. It describes the implications of aging on the nervous system, metabolism, immunity and stem cells as well as care for the elderly. The book is an ideal companion for both new and established researchers in the field and is also useful for educators, clinicians and policy makers.
Inflammation and Cancer
Author: Bharat B. Aggarwal
Publisher: Springer
Published: 2014-05-12
Total Pages: 489
ISBN-13: 3034808372
DOWNLOAD EBOOK →This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.
New Insights Into B cell Subsets in Health and Disease
Author: Judith Fraussen
Publisher: Frontiers Media SA
Published: 2022-03-04
Total Pages: 232
ISBN-13: 2889745651
DOWNLOAD EBOOK →Multiple Sclerosis – From Bench to Bedside: Currents Insights into Pathophysiological Concepts and Their Potential Impact on Patients
Author: Paulus Stefan Rommer
Publisher: Frontiers Media SA
Published: 2020-03-13
Total Pages: 253
ISBN-13: 288963566X
DOWNLOAD EBOOK →Geriatric Gastroenterology
Author: C. S. Pitchumoni
Publisher: Springer Science & Business Media
Published: 2012-07-26
Total Pages: 660
ISBN-13: 1441916237
DOWNLOAD EBOOK →As aging trends in the United States and Europe in particular are strongly suggestive of increasingly older society, it would be prudent for health care providers to better prepare for such changes. By including physiology, disease, nutrition, pharmacology, pathology, radiology and other relevant associated topics, Geriatric Gastroenterology fills the void in the literature for a volume devoted specifically to gastrointestinal illness in the elderly. This unique volume includes provision of training for current and future generations of physicians to deal with the health problems of older adults. It will also serve as a comprehensive guide to practicing physicians for ease of reference. Relevant to the geriatric age group, the volume covers epidemiology, physiology of aging, gastrointestinal physiology, pharmacology, radiology, pathology, motility disorders, luminal disorders, hepato-biliary disease, systemic manifestations, neoplastic disorders, gastrointestinal bleeding, cancer and medication related interactions and adverse events, all extremely common in older adults; these are often hard to evaluate and judge, especially considering the complex aging physiology. All have become important components of modern medicine. Special emphasis is be given to nutrition and related disorders. Capsule endoscopy and its utility in the geriatric population is also covered. Presented in simple, easy to read style, the volume includes numerous tables, figures and key points enabling ease of understanding. Chapters on imaging and pathology are profusely illustrated. All chapters are written by specialists and include up to date scientific information. Geriatric Gastroenterology is of great utility to residents in internal medicine, fellows in gastroenterology and geriatric medicine as well as gastroenterologists, geriatricians and practicing physicians including primary care physicians caring for older adults.
