Author: E. Rajka
Publisher: Springer Science & Business Media
Published: 2013-11-11
Total Pages: 205
ISBN-13: 1461572371
DOWNLOAD EBOOK →SPECIFICITY It is a basic assumption that, for reasons unknown, the constituents of the human body may become antigenic, and then the patient produces antibodies against them. Some autoantibodies are tissue specific (e.g. haemolytic anaemia, pernicious anaemia) whereas others are non-tissue specific (e.g. systemic lupus erythematosus). To prove 'autoimmunity' in the strict sense is not an easy task. In any event, the outcome of antigenic stimulation-whether antibody formation or tolerance-seems to depend on the same factors for autoantigens as it does for any other antigen [146]. Rabbits rendered tolerant to bovine serum albumin respond to immunization with human serum albumin, and in doing so frequently produce antibodies that react with bovine serum albumin, which means the termination of tolerance. This is of special interest as a model of autoimmune disease since natural tolerance of body constituents might be terminated by immunization with a cross-reactive antigen from the environment (266]. It cannot be overemphasized how difficult it could be, at least in several in stances, to delineate specific from non-specific events in any immunological pro cess. Cyclic AMP may be one of the examples for non-specific inducers, whereas thymopoietin (25a ], for instance, induces only the differentiation of cells with thymus-specific antigens. The participation of cells recruited by lymphokines also represents non-specific amplification. Lymphocytes of unrelated specificity con tinue to accumulate in experimental autoimmune inflammation after elimination of the specifically sensitized cells that initiated the inflammation [262].
Author: E. Rajka
Publisher: Springer
Published: 1974-11-15
Total Pages: 0
ISBN-13: 9781461345411
DOWNLOAD EBOOK →A monograph in German, el,Litled Allergie und allergische Erkrankungen, edited by the late Edmund Rajka, Corresponding Member of the Hungarian Academy of Sciences, was published in 1959. The second edition, revised and completed according to contemporary advances in allergology and immunology, was pub lished in Russian seven years later, in 1966. Both volumes dealt with the theore tical and clinical aspects of allergology and allergic diseases on the basis of the information emerging from fundamental immunological research. - Demand for an English version of the monograph was realized immediately after the second edition. Advances in the discipline of molecular biology, accu mulating immunological knowledge and changes in outlook had by then affected the entire view of clinical medicine. Allergology, recently also known as clinical immunology as it provides clues to practically all branches of clinical medicine, has ceased to be the chosen field of specialists. A knowledge in this field is now an essential prerequisite of modern clinical practice and research. It was in view of these facts that the compilation of this volume was begun; unfortunately, having already done the greater part of the work, Professor Rajka died suddenly. Regrettably, he did not live to see the publication of this book, to the editing of which he devoted so much time and energy. Thus his co-workers undertook the task of completion in the spirit of his instructions and with all due respect to his scientific legacy.
Author: E. Rajka
Publisher: Springer
Published: 2011-10-21
Total Pages: 302
ISBN-13: 9781461345435
DOWNLOAD EBOOK →A monograph in German, el,Litled Allergie und allergische Erkrankungen, edited by the late Edmund Rajka, Corresponding Member of the Hungarian Academy of Sciences, was published in 1959. The second edition, revised and completed according to contemporary advances in allergology and immunology, was pub lished in Russian seven years later, in 1966. Both volumes dealt with the theore tical and clinical aspects of allergology and allergic diseases on the basis of the information emerging from fundamental immunological research. - Demand for an English version of the monograph was realized immediately after the second edition. Advances in the discipline of molecular biology, accu mulating immunological knowledge and changes in outlook had by then affected the entire view of clinical medicine. Allergology, recently also known as clinical immunology as it provides clues to practically all branches of clinical medicine, has ceased to be the chosen field of specialists. A knowledge in this field is now an essential prerequisite of modern clinical practice and research. It was in view of these facts that the compilation of this volume was begun; unfortunately, having already done the greater part of the work, Professor Rajka died suddenly. Regrettably, he did not live to see the publication of this book, to the editing of which he devoted so much time and energy. Thus his co-workers undertook the task of completion in the spirit of his instructions and with all due respect to his scientific legacy.
Author: E. Rajka
Publisher: Springer
Published: 1977-02-01
Total Pages: 408
ISBN-13: 9780306377570
DOWNLOAD EBOOK →Author: E. Rajka
Publisher: Springer
Published: 1974-11-01
Total Pages: 456
ISBN-13: 9780306377518
DOWNLOAD EBOOK →Author: Miklós Benczúr
Publisher:
Published: 1974
Total Pages: 456
ISBN-13: 9789630504683
DOWNLOAD EBOOK →